{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:53:51Z","timestamp":1767167631419,"version":"build-2238731810"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T00:00:00Z","timestamp":1657065600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Key Military Logistics Research Projects","award":["BWS12J008"],"award-info":[{"award-number":["BWS12J008"]}]},{"name":"Key Military Logistics Research Projects","award":["BLB19J012"],"award-info":[{"award-number":["BLB19J012"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2022,7,6]]},"abstract":"<jats:p>Objective. This study was aimed at investigating the effects of different types of fluid restriction fluid resuscitation on the immune dysfunction and organ injury of hemorrhagic shock rats under a hypothermic environment. Methods. SD rats were divided into sham operation group (SHAM), hemorrhagic shock model group (HS), crystal liquid limited resuscitation group (CRLLR), colloidal liquid limited resuscitation group (COLLR), and nonlimited resuscitation group (NLR); rats in each group were placed in a low-temperature environment of 0-5\u00b0C for 30\u2009min, and then, a hemorrhagic shock rat model was prepared. Sodium lactate Ringer\u2019s restricted resuscitation solution, hydroxyethyl starch restricted resuscitation solution, and hydroxyethyl starch were used for resuscitation, and hemodynamic examination was performed. The mortality rate, inflammatory factors, oxidative stress factors, and immune function were detected by ELISA. The dysfunction and injury of the intestinal, lung, liver, and kidney were examined by histological methods. Results. Hemorrhagic shock resulted in decreased immune function and activation of inflammation. Unrestricted fluid infusion further activated the inflammatory response. The crystalloid-restricted fluid infusion performed effectively to regulate inflammatory response, promote antioxidative activity, and reduce the immunosuppressive reaction. Rehydration could regulate the coagulation. The hydroxyethyl starch reduced the expression of platelet glycoproteins Ib and IIb\/IIIa and blocked the binding of fibrinogen to activated platelets, thereby inhibiting intrinsic coagulation and platelet adhesion and aggregation. Rats in the CRLLR group showed to relieve the injury of the lung, liver, kidney, and intestine from hemorrhagic shock in low-temperature environment. Conclusion. The early application of restrictive crystalloid resuscitation in hemorrhagic shock rats in hypothermic environment showed the best therapy results. Early LR-restrictive fluid replacement promotes the balance of inflammatory response and the recovery of immunosuppressive state, resists oxidative stress, stabilizes the balance of coagulation and fibrinolysis, improves coagulation function, and relieves organ injury.<\/jats:p>","DOI":"10.1155\/2022\/4982047","type":"journal-article","created":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T17:20:34Z","timestamp":1657128034000},"page":"1-12","source":"Crossref","is-referenced-by-count":1,"title":["Effects of Different Types of Early Restrictive Fluid Resuscitation on Immune Function and Multiorgan Damage on Hemorrhagic Shock Rat Model in a Hypothermic Environment"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5139-9002","authenticated-orcid":true,"given":"Linlin","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Anesthesia, Postgraduate Training Base of Jinzhou Medical University in the General Hospital of Northern Theater Command, Shenyang 110016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7262-5788","authenticated-orcid":true,"given":"Lin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, General Hospital of Northern Theater Command, Shenyang 110016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0323-7460","authenticated-orcid":true,"given":"Jianyu","family":"Zu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Suzhou BOE Hospital 215505, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6564-9332","authenticated-orcid":true,"given":"Xinyuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, General Hospital of Northern Theater Command, Shenyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4484-4785","authenticated-orcid":true,"given":"Lin","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, General Hospital of Northern Theater Command, Shenyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4976-5552","authenticated-orcid":true,"given":"Yingjie","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, General Hospital of Northern Theater Command, Shenyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4509-9035","authenticated-orcid":true,"given":"Yugang","family":"Diao","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, General Hospital of Northern Theater Command, Shenyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1705649"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.36290\/vnl.2019.038"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2017.11.025"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1111\/vec.13126"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1136\/jramc-2016-000723"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18168719"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2012.12.027"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2016.08.007"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2020.05.008"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.12968\/bjon.2018.27.8.449"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1186\/s40635-016-0088-z"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003779"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2017.08.005"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.medin.2018.11.008"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000025143"},{"issue":"3","key":"16","first-page":"191","article-title":"Comparison of permissive hypotensive resuscitation, low-volume fluid resuscitation, and aggressive fluid resuscitation therapy approaches in an experimental uncontrolled hemorrhagic shock model","volume":"16","author":"M. 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