{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T11:16:46Z","timestamp":1767093406489,"version":"3.40.5"},"reference-count":44,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T00:00:00Z","timestamp":1653868800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Research Department of Tehran University of Medical Sciences","award":["94-02-86-27538"],"award-info":[{"award-number":["94-02-86-27538"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,5,30]]},"abstract":"<jats:p>Background. In traditional Persian medicine, Drimia maritima, with the popular name Squill, has been used to alleviate phlegm dyspnea. Squill has also been shown to have anti-inflammatory and anticholinergic properties. The goal of this research was to see how effective and safe Squill-Oxymel was in treating COPD patients. Method. Forty-two COPD patients were examined for eight weeks in two groups. Patients underwent a 6-minute walk test to assess the treatment\u2019s effectiveness at the beginning and conclusion of the intervention. We utilized St. George\u2019s Respiratory Questionnaire (SGRQ) to evaluate the subjective symptoms of patients in order to measure their quality of life. Results. Patients who received Squill-Oxymel showed a statistically significant increase in 6MWT distance (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.011<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). The mean O2 saturation at the end of the 6MWT before the intervention was significantly greater in the placebo group. (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.008<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). In terms of questionnaire variables, there was a significant difference between placebo and Squill-Oxymel groups in the mean presymptom score (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>0.009<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>) and the mean post-symptom score (<jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                        <g:mo>=<\/g:mo>\n                        <g:mn>0.004<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>). Conclusions. The findings of this research provide preliminary evidence for the effectiveness and safety of Squill-Oxymel as an add-on therapy in individuals with mild COPD.<\/jats:p>","DOI":"10.1155\/2022\/5024792","type":"journal-article","created":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T23:50:09Z","timestamp":1653954609000},"page":"1-8","source":"Crossref","is-referenced-by-count":5,"title":["An Add-On Treatment for Moderate COPD with Squill-Oxymel (a Traditional Formulation from Drimia maritima (L.) Stearn): A Pilot Randomized Triple-Blinded Placebo-Controlled Clinical Trial"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4765-5963","authenticated-orcid":true,"given":"Maryam","family":"Mohammadi\u2013Araghi","sequence":"first","affiliation":[{"name":"Department of Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8788-4544","authenticated-orcid":true,"given":"Alireza","family":"Eslaminejad","sequence":"additional","affiliation":[{"name":"Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4750-3049","authenticated-orcid":true,"given":"Hossein","family":"Karegar-Borzi","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Science, Kerman, Iran"},{"name":"Department of Traditional Medicine, Faculty of Persian Medicine, Kerman University of Medical Science, Kerman, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6325-0662","authenticated-orcid":true,"given":"Saeideh","family":"Mazloomzadeh","sequence":"additional","affiliation":[{"name":"Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8368-6866","authenticated-orcid":true,"given":"Fatemeh","family":"Nejatbakhsh","sequence":"additional","affiliation":[{"name":"Department of Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran"},{"name":"Food Microbiology Research Center, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000019396"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000020035"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2011.02.005"},{"volume-title":"Teb Akbari","year":"2008","author":"M. 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Mammadov","year":"2010","journal-title":"Iranian Journal of Chemistry and Chemical Engineering (International English Edition)"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/5024792.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/5024792.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/5024792.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T23:50:27Z","timestamp":1653954627000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ecam\/2022\/5024792\/"}},"subtitle":[],"editor":[{"given":"Chunpeng","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,5,30]]},"references-count":44,"alternative-id":["5024792","5024792"],"URL":"https:\/\/doi.org\/10.1155\/2022\/5024792","relation":{},"ISSN":["1741-4288","1741-427X"],"issn-type":[{"type":"electronic","value":"1741-4288"},{"type":"print","value":"1741-427X"}],"subject":[],"published":{"date-parts":[[2022,5,30]]}}}