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Ginsenoside Rg1 (GRg1), a bioactive ingredient extracted from ginseng, has benefit effects on health. In this study, 11 potential targets of GRg1 against ALD were firstly obtained by network pharmacology. KEGG pathway enrichment showed that GRg1\u2010target\u2010ALD was closely related to Toll\u2010like receptor (TLR) and nuclear factor\u2010kappa B (NF\u2010<jats:italic>\u03ba<\/jats:italic>B) signaling pathways. In addition, GRg1 decreased antioxidant levels and increased oxidative levels in alcohol\u2010treated mice, which alleviated oxidative stress\u2010induced hepatic damage. GRg1 enhanced intestinal barrier function <jats:italic>via<\/jats:italic> upregulating the levels of tight junction protein and immunoglobulin A. GRg1 also reduced alcohol\u2010induced inflammation by suppressing TLR4\/NF\u2010<jats:italic>\u03ba<\/jats:italic>B pathway, which was consistent with the prediction of network targets. Moreover, GRg1 altered GM population, and Verrucomicrobia, Bacteroidetes, <jats:italic>Akkermansia<\/jats:italic>, <jats:italic>Bacteroides<\/jats:italic>, <jats:italic>Lachnospiraceae_NK4A136_group<\/jats:italic>, and <jats:italic>Alloprevotella<\/jats:italic> played positive association with intestinal barrier indicators and negative correlation with hepatic inflammation biomarkers. The results suggest that GRg1 administration might be a promising strategy for protection of alcohol\u2010induced liver damage.<\/jats:p>","DOI":"10.1155\/2022\/5025237","type":"journal-article","created":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T22:35:31Z","timestamp":1661294131000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Hepatoprotective Mechanism of Ginsenoside Rg1 against Alcoholic Liver Damage Based on Gut Microbiota and Network Pharmacology"],"prefix":"10.1155","volume":"2022","author":[{"given":"Ting","family":"Xia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoyan","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Qiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3311-770X","authenticated-orcid":false,"given":"Jianbo","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5752-4065","authenticated-orcid":false,"given":"Min","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,23]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30415-7"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mpmed.2019.08.009"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3746"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms161125942"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2020.08.014"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.10.019"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2020.07.004"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2018.05.015"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.10.042"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2020.02.004"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2008.01.028"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells7120270"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b18-00132"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2018.07.012"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.118"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.112689"},{"key":"e_1_2_12_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/tox.22616"},{"key":"e_1_2_12_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117669"},{"key":"e_1_2_12_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2016.08.004"},{"key":"e_1_2_12_20_2","doi-asserted-by":"publisher","DOI":"10.1079\/pns2006496"},{"key":"e_1_2_12_21_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20020395"},{"key":"e_1_2_12_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-020-0438-5"},{"key":"e_1_2_12_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.107327"},{"key":"e_1_2_12_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2010.02.022"},{"key":"e_1_2_12_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26494"},{"key":"e_1_2_12_26_2","first-page":"280","article-title":"Comparative levels of ALT, AST, ALP and GGT in liver associated diseases","volume":"3","author":"Hyder M. 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