{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:01:37Z","timestamp":1787662897591,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T00:00:00Z","timestamp":1666051200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology Research and Practice"],"published-print":{"date-parts":[[2022,10,18]]},"abstract":"<jats:p>Pancreatitis usually presents with characteristic abdominal pain, radiological findings, and elevated lipase. The presence of jaundice may hint at a biliary etiology; however, it is not always present. We hypothesized that the presence of jaundice is associated with worse outcomes in patients admitted with pancreatitis. We conducted a retrospective analysis using the National Inpatient Sample, inquiring about patients admitted with pancreatitis with and without jaundice between October 2015 and December 2017. The primary outcome was in-hospital mortality in patients admitted for pancreatitis with and without jaundice. Secondary outcomes were the median length of stay, hospitalization cost, the incidence of ventilator-dependent respiratory failure (VDRF), acute respiratory distress syndrome (ARDS), sepsis, septic shock, dehydration and electrolyte disturbances, and ascites. A total of 1,267,744 patients were admitted with pancreatitis from October 2015 to December 2017. Among them, 8855 (0.7%) had concomitant jaundice on presentation. In-hospital mortality in this group was 4.3%. The patients with pancreatitis and jaundice had higher odds of in-hospital mortality (adjusted odds ratio [aOR]: 1.51, 99% CI 1.35\u20131.68, <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.0001<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>) as compared to those without jaundice. Patients with jaundice showed a significantly higher incidence of sepsis (15.2% vs. 9.6%, <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.0001<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>), septic shock (4.1% vs. 2.9%, <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>p<\/e:mi>\n                        <e:mo>&lt;<\/e:mo>\n                        <e:mn>0.0001<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>), ascites (6.5% vs. 3.1%, <jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>p<\/g:mi>\n                        <g:mo>&lt;<\/g:mo>\n                        <g:mn>0.0001<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>), and dehydration and electrolyte disorders (47.6% vs. 43.8%, <jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>p<\/i:mi>\n                        <i:mo>&lt;<\/i:mo>\n                        <i:mn>0.0001<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>). Patients with jaundice also had higher total hospital costs ($11,412 vs. $7893, <jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mi>p<\/k:mi>\n                        <k:mo>&lt;<\/k:mo>\n                        <k:mn>0.0001<\/k:mn>\n                     <\/k:math>\n                  <\/jats:inline-formula>). There was no statistical difference in ARDS, VDRF, and median length of stay. In conclusion, patients admitted for pancreatitis with jaundice had worse outcomes, including in-hospital mortality and complications, compared to those without jaundice.<\/jats:p>","DOI":"10.1155\/2022\/5048061","type":"journal-article","created":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T16:35:12Z","timestamp":1666110912000},"page":"1-7","source":"Crossref","is-referenced-by-count":3,"title":["Jaundice on Presentation Is Associated with Higher In-Patient Mortality and Complications in Patients Admitted for Acute Pancreatitis: A Retrospective Study Based on National Inpatient Sample Database"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8418-7348","authenticated-orcid":true,"given":"Nishit","family":"Patel","sequence":"first","affiliation":[{"name":"Internal Medicine Department, St. Luke\u2019s University Hospital Health Network Bethlehem, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna","family":"Bodrya","sequence":"additional","affiliation":[{"name":"Trumbull Regional Medical Center, Niles, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirten","family":"Patel","sequence":"additional","affiliation":[{"name":"St. Mary Mercy Hospital, Langhorne, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishi","family":"Patel","sequence":"additional","affiliation":[{"name":"University of South Columbia (Pharmacy), Columbia, SC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhruvanshu","family":"Patel","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, St. Luke\u2019s University Hospital Health Network Bethlehem, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronak","family":"Modi","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, St. Luke\u2019s University Hospital Health Network, Bethlehem, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayaz","family":"Matin","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, St. Luke\u2019s University Hospital Health Network, Bethlehem, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.218"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1007\/s12328-018-0881-1"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1159\/000212091"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.2217\/clp.13.44"},{"key":"5","first-page":"85","article-title":"Acute pancreatitis in pregnancy","volume":"61","author":"C. C. Chang","year":"1998","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"6","first-page":"23","article-title":"Hyperlipidemia of diuretic therapy","volume":"91 Suppl","author":"R. Ames","year":"1998","journal-title":"Archives des Maladies du Coeur et des Vaisseaux"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1007\/s00534-005-1047-3"},{"key":"8","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/BF02795245","article-title":"Hypertriglyceridaemia and abnormalities of triglyceride catabolism persisting after pancreatitis","volume":"1","author":"P. N. Durrington","year":"1986","journal-title":"International Journal of Pancreatology"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e31816074a1"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcg.0000436438.60145.5a"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2014.08.008"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-200210000-00011"},{"issue":"64","key":"13","first-page":"1274","article-title":"Alcoholic chronic pancreatitis with simultaneous multiple severe complications\u2014extrahepatic portal obliteration, obstructive jaundice and duodenal stricture","volume":"52","author":"S. Kakizaki","year":"2005","journal-title":"Hepato-Gastroenterology"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.10351"},{"key":"15","article-title":"Introduction to the HCUP National Inpatient Sample (NIS) [Sep;2020 ]","author":"Healthcare Cost and Utilization Project","year":"2017"},{"key":"16","first-page":"105","article-title":"Impact of diabetes mellitus on outcomes of patients with knee osteoarthritis who underwent knee arthroplasty: an analysis of the nationwide inpatient sample","volume":"12","author":"P. E. Ojemolon","year":"2020","journal-title":"Cureus"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197508000-00005"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMct1208450"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1136\/gut.25.12.1340"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.152702"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3182a9f879"}],"container-title":["Gastroenterology Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/grp\/2022\/5048061.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/grp\/2022\/5048061.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/grp\/2022\/5048061.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T16:35:18Z","timestamp":1666110918000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/grp\/2022\/5048061\/"}},"subtitle":[],"editor":[{"given":"Leticia","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,10,18]]},"references-count":21,"alternative-id":["5048061","5048061"],"URL":"https:\/\/doi.org\/10.1155\/2022\/5048061","relation":{},"ISSN":["1687-630X","1687-6121"],"issn-type":[{"value":"1687-630X","type":"electronic"},{"value":"1687-6121","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10,18]]}}}