{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:00:46Z","timestamp":1791820846411,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T00:00:00Z","timestamp":1663804800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Tai\u2019an Science and Technology","award":["2021NS267"],"award-info":[{"award-number":["2021NS267"]}]},{"name":"Tai\u2019an Science and Technology","award":["LKJGG2021W095"],"award-info":[{"award-number":["LKJGG2021W095"]}]},{"name":"Shandong Geriatrics Association","award":["2021NS267"],"award-info":[{"award-number":["2021NS267"]}]},{"name":"Shandong Geriatrics Association","award":["LKJGG2021W095"],"award-info":[{"award-number":["LKJGG2021W095"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2022,9,22]]},"abstract":"<jats:p>Objective. To investigate the prognosis and influencing factors of early microsurgery for severe hypertensive brainstem hemorrhage. Methods. The clinical data of 19 patients with severe hypertensive brainstem hemorrhage treated in the Department of Neurosurgery of the Second Affiliated Hospital of Shandong First Medical University between January 2018 and December 2021 were retrospectively analyzed. The clinical efficacy and risk factors affecting the prognosis were analyzed by chi-square test and multivariate logistic regression. Results. A total of 19 patients with severe hypertensive brainstem hemorrhage were treated by early microsurgery, including 14 cases by subtemporal approach and 5 cases by retrosigmoid approach. After 3 months of follow-up, 6 patients died and 13 patients survived. The 30-day and 90-day mortality rates were 21.1% and 31.6%, respectively, and the good prognosis rate was 15.4%. Univariate analysis showed that hematoma volume and hematoma clearance rate might be the factors affecting the prognosis of patients with severe hypertensive brainstem hemorrhage; the observed difference was statistically significant (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). Multivariate logistic regression analysis further confirmed that hematoma volume was an independent factor affecting the death of patients with brainstem hemorrhage (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.05<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>), while hematoma volume (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>B<\/e:mi>\n                     <\/e:math>\n                  <\/jats:inline-formula>: 2.909, OR: 18.332, 95% CI: 1.020\u2013329.458, <jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                     <\/g:math>\n                  <\/jats:inline-formula>: 0.048) was a risk factor. Conclusion. Hematoma volume resulted as an independent factor affecting the death of patients with severe hypertensive brainstem hemorrhage. Early microsurgical clearance of brainstem hematoma contributed to reducing the 30-day and 90-day mortality and improving the prognosis of patients.<\/jats:p>","DOI":"10.1155\/2022\/5062591","type":"journal-article","created":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T19:35:08Z","timestamp":1663875308000},"page":"1-7","source":"Crossref","is-referenced-by-count":10,"title":["Prognosis and Influencing Factors of Early Microsurgery for Severe Hypertensive Brainstem Hemorrhage"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6295-223X","authenticated-orcid":true,"given":"Xianbing","family":"Meng","sequence":"first","affiliation":[{"name":"The Second Affiliated Hospital of Shandong First Medical University, Taian, Shandong Province 271000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Shandong First Medical University, Taian, Shandong Province 271000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianguang","family":"Pei","sequence":"additional","affiliation":[{"name":"The First Hospital of Handan City, Handan, Hebei Province 056002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7831-186X","authenticated-orcid":true,"given":"Fangmin","family":"Xie","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Shandong First Medical University, Taian, Shandong Province 271000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2012.08.022"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.727962"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.asjsur.2020.04.016"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2018.09.055"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/0895-6111(88)90078-x"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2011.26.1.100"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1007\/s10143-007-0081-9"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.inat.2018.10.015"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.26599\/JNR.2020.9040024"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2021.10.100"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2020.05.207"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1007\/s10143-019-01081-9"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1007\/s10143-021-01683-2"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.4414\/smw.2019.20062"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/S1042-3680(18)30572-2"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000069"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12309"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1990.73.2.0181"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2018.04.063"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.007095"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.017866"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1177\/2396987317752729"},{"issue":"10","key":"23","first-page":"1246","article-title":"Exploring the optimal operation time for patients with hypertensive intracerebral hemorrhage: tracking the expression and progress of cell apoptosis of prehematomal brain tissues","volume":"123","author":"X. 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