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Nowadays, its clinical use is limited due to various toxicities, including nephrotoxicity. Even though the mechanisms are not well understood, cyclophosphamide-induced nephrotoxicity is reported to be mediated through oxidative stress. This review focuses on the potential role of natural and plant-derived antioxidants in preventing cyclophosphamide-induced nephrotoxicity.<\/jats:p>","DOI":"10.1155\/2022\/5096825","type":"journal-article","created":{"date-parts":[[2022,4,17]],"date-time":"2022-04-17T00:36:27Z","timestamp":1650155787000},"page":"1-12","source":"Crossref","is-referenced-by-count":47,"title":["Potential Protective Effects of Antioxidants against Cyclophosphamide-Induced Nephrotoxicity"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6196-0361","authenticated-orcid":true,"given":"Muluken Altaye","family":"Ayza","sequence":"first","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy, College of Medicine and Health Sciences, Hawassa University, Hawassa, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7089-421X","authenticated-orcid":true,"given":"Kaleab Alemayehu","family":"Zewdie","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, School of Pharmacy, Mekelle University, Mekelle, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias Fitsum","family":"Yigzaw","sequence":"additional","affiliation":[{"name":"Clinical Pharmacy Unit, School of Pharmacy, College of Health Sciences, Mekelle University, Mekelle, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solomon Gashaw","family":"Ayele","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmacy, College of Health Sciences, Mekelle University, Mekelle, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9743-0346","authenticated-orcid":true,"given":"Bekalu Amare","family":"Tesfaye","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, School of Pharmacy, Mekelle University, Mekelle, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6274-0106","authenticated-orcid":true,"given":"Gebrehiwot Gebremedhin","family":"Tafere","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, School of Pharmacy, Mekelle University, Mekelle, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4813-9293","authenticated-orcid":true,"given":"Muzey Gebreyohannes","family":"Abrha","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, School of Pharmacy, Mekelle University, Mekelle, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.08.014"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1038\/181931a0"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/b978-012595961-2\/50049-4"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.12406"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200544110-00003"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/s0378-6080(08)00027-5"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/b978-1-4160-3343-1.50025-6"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-019-02589-1"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2009.146"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-016-3152-1"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-017-0536-3"},{"issue":"6","key":"12","first-page":"743","article-title":"Drug-induced nephrotoxicity","volume":"78","author":"C. 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