{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T21:13:34Z","timestamp":1762377214469,"version":"3.37.3"},"reference-count":46,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T00:00:00Z","timestamp":1656374400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["222300420568","SBGJ202101014","20-21ZYZD14","YXKC2020015"],"award-info":[{"award-number":["222300420568","SBGJ202101014","20-21ZYZD14","YXKC2020015"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Medical Science and Technology Project of Henan Province","award":["222300420568","SBGJ202101014","20-21ZYZD14","YXKC2020015"],"award-info":[{"award-number":["222300420568","SBGJ202101014","20-21ZYZD14","YXKC2020015"]}]},{"name":"Major Scientific Research Projects of Traditional Chinese Medicine in Henan Province","award":["222300420568","SBGJ202101014","20-21ZYZD14","YXKC2020015"],"award-info":[{"award-number":["222300420568","SBGJ202101014","20-21ZYZD14","YXKC2020015"]}]},{"name":"Cultivation of Young and Middle-aged Health Science, and Technology Innovation Leading Talents in Henan Province","award":["222300420568","SBGJ202101014","20-21ZYZD14","YXKC2020015"],"award-info":[{"award-number":["222300420568","SBGJ202101014","20-21ZYZD14","YXKC2020015"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2022,6,28]]},"abstract":"<jats:p>Introduction. Papillary thyroid cancer (PTC) is one of the most prevalent endocrine malignancies that has increased in recent decades around the world. Although the indicator for navigating the surgical extent in PTC patients is still in debate, a key issue is how to predict that there are undetected preoperative tumors in the contralateral thyroid lobe. This study aims to find risk factors for contralateral occult papillary thyroid cancer (COPTC) to facilitate more accurate surgical decisions made for patients with PTC. Materials and Methods. In our study, we included 229 patients who underwent total thyroidectomy plus central and ipsilateral lateral lymph nodes dissection from January 1, 2019, to September 1, 2021. Univariate and multivariate logistic regression analyses were conducted to assess the association between COPTC and clinical-pathological characteristics, as well as the relation between the diameter of the occult lesions and predictors. The forest plot was plotted to visualize the prediction factors from the output of the multivariate regression analysis. A ROC curve was used to evaluate the combining potency of all the risk factors. Results. Of the 229 patients included in our study, 46 with COPTC were assigned to the case group, representing 20.1% in this study. Multifocality in one lobe (OR\u2009=\u20092.21, <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.03<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>), intact capsule (OR\u2009=\u20092.54, <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.01<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>), central lymph node metastasis (OR\u2009=\u20093.00, <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>0.02<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>), and Hashimoto\u2019s thyroiditis (OR\u2009=\u20092.08, P\u2009=\u20090.04) are more prone to present contralateral occult papillary thyroid carcinoma. The ROC curve of the aggregate potency of the risk factors presents AUC\u2009=\u20090.701 (<jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                        <g:mo>&lt;<\/g:mo>\n                        <g:mn>0.001<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>), and the best cutoff value was 2.02, with a sensitivity of 78.3% and specificity of 55.2%. Furthermore, there was no statistical correlation between the diameter of the occult tumor and the four obtained variables. Conclusion. Patients with multifocality in one lobe, intact capsule, central lymph node metastasis, and HT may harbor contralateral papillary thyroid carcinoma. It is essential to be prudent to make a surgical or follow-up decision on these patients. In addition, more clinical rather than postoperative pathological indicators need to be revealed in the future.<\/jats:p>","DOI":"10.1155\/2022\/5112985","type":"journal-article","created":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T19:07:36Z","timestamp":1656443256000},"page":"1-9","source":"Crossref","is-referenced-by-count":4,"title":["Risk Factors for Contralateral Occult Papillary Thyroid Carcinoma in Patients with Clinical Unilateral Papillary Thyroid Carcinoma: A Case-Control Study"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8157-9242","authenticated-orcid":true,"given":"Liu","family":"Yihao","sequence":"first","affiliation":[{"name":"Thyroid Surgery Department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Shuo","sequence":"additional","affiliation":[{"name":"Thyroid Surgery Department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Pu","sequence":"additional","affiliation":[{"name":"Thyroid Surgery Department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wang","family":"Zipeng","sequence":"additional","affiliation":[{"name":"Thyroid Surgery Department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun","family":"Hanlin","sequence":"additional","affiliation":[{"name":"Thyroid Surgery Department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang","family":"Qungang","sequence":"additional","affiliation":[{"name":"Thyroid Surgery Department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wang","family":"Yongfei","sequence":"additional","affiliation":[{"name":"Thyroid Surgery Department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5880-9468","authenticated-orcid":true,"given":"Yin","family":"Detao","sequence":"additional","affiliation":[{"name":"Thyroid Surgery Department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"},{"name":"Engineering Research Center of Multidisciplinary Diagnosis and Treatment of Thyroid Cancer of Henan Province, Zhengzhou, China"},{"name":"Key Medicine Laboratory of Thyroid Cancer of Henan Province, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29251"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2016.110"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f4706"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2010.0458"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-0987"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2014.264"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1080\/10408363.2018.1450830"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18061292"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2014.0353"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2017.0034"},{"key":"11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/thy.2015.0020","article-title":"2015 American thyroid association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American thyroid association guidelines task force on thyroid nodules and differentiated thyroid cancer","volume":"26","author":"B. R. Haugen","year":"2016","journal-title":"Thyroid"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2017.0129"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1530\/erc-15-0152"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-015-3024-6"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2020.01.023"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-1600-z"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2016.0190"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.asjsur.2021.01.004"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2014.1"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2017.1442"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5728-8"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000200428.26975.86"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.11.040"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.553577"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13506"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-009-0906-6"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.675643"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-013-1913-0"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-016-3701-0"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2016.07.037"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2019.03.031"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2020.02.003"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1361158"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-020-09650-1"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2019.01.025"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.21037\/gs-19-157"},{"key":"37","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.cell.2014.09.050","article-title":"Integrated genomic characterization of papillary thyroid carcinoma","volume":"159","author":"Cancer Genome Atlas Research Network","year":"2014","journal-title":"Cell"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2015.05.016"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1530\/ec-19-0246"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2018.0509"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1097\/cco.0000000000000150"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2006.12.037"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1177\/0194599812472426"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2014.09.001"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2019.0347"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2020.0330"}],"container-title":["International Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ije\/2022\/5112985.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ije\/2022\/5112985.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ije\/2022\/5112985.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T19:07:46Z","timestamp":1656443266000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ije\/2022\/5112985\/"}},"subtitle":[],"editor":[{"given":"Aman","family":"Rajpal","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,6,28]]},"references-count":46,"alternative-id":["5112985","5112985"],"URL":"https:\/\/doi.org\/10.1155\/2022\/5112985","relation":{},"ISSN":["1687-8345","1687-8337"],"issn-type":[{"type":"electronic","value":"1687-8345"},{"type":"print","value":"1687-8337"}],"subject":[],"published":{"date-parts":[[2022,6,28]]}}}