{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T20:57:12Z","timestamp":1789419432567,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T00:00:00Z","timestamp":1656979200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["8177051154"],"award-info":[{"award-number":["8177051154"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["8170150971"],"award-info":[{"award-number":["8170150971"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2022,7,5]]},"abstract":"<jats:p>Background. Complications after colon surgery are a major obstacle to postoperative recovery. The purpose of this study was to investigate the effect of electroacupuncture (EA) at Zusanli (ST36) on gastrointestinal motility in rats after colonic anastomosis and the mechanism of transient receptor potential vanillin 1 (TRPV1) channel in regulating gastrointestinal motility, pain, and inflammation. Methods. The rats were randomly divided into six groups, including the control, model, EA, sham-EA, capsaicin, and capsaicin+EA groups, with preoperative capsaicin pretreatment and EA treatment at ST36 acupoint after surgery. Rats were treated using EA at ST36 or sham acupoints after surgery for 5 days. Capsaicin was intraperitoneally injected into rats 3 hours before surgery. Gastrointestinal motility was assessed by measuring the gastric residue, small intestinal propulsion in vivo, contractile tension, and frequency of isolated muscle strips in vitro. The mechanical withdrawal threshold (MWT) of abdominal incision skin and spontaneous nociceptive scores were observed and recorded in rats after colon anastomosis. The expressions of TRPV1, substance P (SP), neurokinin 1 (NK1) receptor, nuclear factor kappa-B (NF-\u03baB), interleukin- (IL-) 6, L-1\u03b2, and tumor necrosis factor- (TNF-) \u03b1 were determined. Results. Compared with the model group, electroacupuncture at ST36 point could significantly reduce the residual rate of stomach in rats after operation and increase the propulsive force of the small intestine and the contraction tension of the isolated smooth muscle. Electroacupuncture also increased postoperative day 3 MWT values and decreased postoperative spontaneous nociception scores. In addition, electroacupuncture treatment downregulated the expressions of IL-6, IL-1\u03b2, TNF-\u03b1, TRPV1, NF-\u03baB, SP, and NK1 receptors in the colon tissue of rats after colonic anastomosis. Conclusions. Our study showed that electroacupuncture at ST36 acupoint could improve gastrointestinal motility in rats after colonic anastomosis and relieve intestinal inflammation and pain. The mechanism may be to inhibit the activation of NF-\u03baB and SP\/NK1 receptor signaling pathways by inhibiting TRPV1.<\/jats:p>","DOI":"10.1155\/2022\/5113473","type":"journal-article","created":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T17:05:55Z","timestamp":1657040755000},"page":"1-14","source":"Crossref","is-referenced-by-count":11,"title":["Effects of Electroacupuncture on Gastrointestinal Motility Function, Pain, and Inflammation via Transient Receptor Potential Vanilloid 1 in a Rat Model after Colonic Anastomoses"],"prefix":"10.1155","volume":"2022","author":[{"given":"Xuelai","family":"Zhong","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Harbin Medical University Cancer Hospital, Harbin 150081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaodi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Harbin Medical University Cancer Hospital, Harbin 150081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Harbin Medical University Cancer Hospital, Harbin 150081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Harbin Medical University Cancer Hospital, Harbin 150081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The Fourth Hospital of Harbin Medical University, Harbin 150081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1111-9405","authenticated-orcid":true,"given":"Guonian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The Fourth Hospital of Harbin Medical University; Pain Research Institute of Heilongjiang Academy of Medical Science, 150 Haping Rd, Nangang District, Harbin 150081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2013.06.009"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-411545-3.00014-6"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1177\/0964528420920288"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-019-05960-5"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.8b00618"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000010877"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i16.4852"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i5.1834"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5068347"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/bs.apcsb.2016.11.002"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-020-3435-6"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S341581"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-68132-w"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2008.12.011"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13318"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i12.1594"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.4103\/sjg.SJG_505_17"},{"issue":"1","key":"18","doi-asserted-by":"crossref","first-page":"64","DOI":"10.59566\/IJBS.2006.2064","article-title":"Suppressive effects of intrathecal application of diazepam on visceral pain and hyperalgesia induced by intracolonic instillation of formalin","volume":"2","author":"J. 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