{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:19:34Z","timestamp":1740140374095,"version":"3.37.3"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T00:00:00Z","timestamp":1644364800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82174486","GZY-KJS-2020-072"],"award-info":[{"award-number":["82174486","GZY-KJS-2020-072"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Administration of Traditional Chinese Medicine","award":["82174486","GZY-KJS-2020-072"],"award-info":[{"award-number":["82174486","GZY-KJS-2020-072"]}]},{"name":"Zhuang Lixing Guangdong Famous Traditional Chinese Medicine Inheritance Studio","award":["82174486","GZY-KJS-2020-072"],"award-info":[{"award-number":["82174486","GZY-KJS-2020-072"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,2,9]]},"abstract":"<jats:p>Parkinson\u2019s disease anxiety (PDA) is a nonmotor symptom of Parkinson\u2019s disease (PD) that is often neglected. PDA poses a far-reaching challenge to the treatment of PD. Acupuncture could be successful in the treatment of PDA. However, the evidence for this is still limited. We propose a two-stage clinical trial. In stage 1, a total of 70 volunteers with PDA will be randomly assigned to either acupuncture (manual acupuncture) or control group (sham acupuncture) in a 1\u2009:\u20091 ratio. Treatments will be performed for four weeks. The change in the Hamilton Rating Scale for Anxiety (HAMA) score from baseline to week 4 and week 12 will be the primary outcome. The levels of adrenocorticotropic hormone (ACTH), cortisol (CORT), serotonin (5-HT), and corticotropin-releasing factor (CRH) in the patients\u2019 serum and the scores on the Hoehn\u2013Yahr Rating Scale and the Unified Parkinson\u2019s Disease Rating Scale (UPDRS) will all be considered among the secondary outcomes. Participants will be followed up until week 12. In stage 2, a total of 82 volunteers with PDA will be randomly assigned to either an acupuncture (manual acupuncture) or a control group (anti-Parkinson drugs only) in a 1\u2009:\u20091 ratio. HAMA score will be the primary outcome. Universality, feasibility and cost effectiveness, Hoehn\u2013Yahr Rating Scale, UPDRS, and serological indicators will be secondary outcomes. Participants will be followed up until week 4. The statistical analysis will include all the allocated individuals. The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine\u2019s Research Ethical Committee authorized this procedure, and the trial is registered with ChiCTR2100047253.<\/jats:p>","DOI":"10.1155\/2022\/5180193","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T20:05:06Z","timestamp":1644437106000},"page":"1-11","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy of Acupuncture for Parkinson\u2019s Disease Anxiety: Two-Stage Protocol for a Randomized Controlled Clinical Trial"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0269-3918","authenticated-orcid":true,"given":"Jing-Qi","family":"Fan","sequence":"first","affiliation":[{"name":"Guangzhou University of Chinese Medicine, Guangzhou 510000, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi-Qiao","family":"Xu","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine, Guangzhou 510000, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan-Yuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine, Guangzhou 510000, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Jing","family":"Lu","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine, Guangzhou 510000, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Yan","family":"Xie","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine, Guangzhou 510000, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Ting","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine, Guangzhou 510000, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7276-9511","authenticated-orcid":true,"given":"Li-Xing","family":"Zhuang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510000, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/s1474-4422(21)00030-2"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25937"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26643"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13217"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-014-0563-z"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.12157"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1177\/0891988712445096"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1142\/s0192415x15500263"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/953109"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27340"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-017-0549-4"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-020-04930-x"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1080\/10749357.2018.1484680"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27602"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X07004606"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10134"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26424"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2018.04.002"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.149.5.719-c"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(14)61393-3"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/s1474-4422(16)00060-0"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-017-0306-y"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1007\/s12576-009-0061-7"},{"key":"24","first-page":"56","article-title":"Diagnostic criteria and treatment guidelines for depression, anxiety and psychotic disorders in Parkinson\u2019s disease","volume":"1","author":"H. 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