{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T13:17:51Z","timestamp":1783603071902,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T00:00:00Z","timestamp":1661299200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2022,8,24]]},"abstract":"<jats:p>To explore the role and possible mechanism of miRNA-212 in heart failure (HF). The rat model of abdominal aortic constriction was constructed, the changes of myocardial morphology were observed by hematoxylin-eosin (HE) staining, and the hypertrophy-related marker molecules were detected by quantitative real-time polymerase chain reaction (qRT-PCR). At the cellular level, phenylephrine and angiotensin II were added to induce cardiomyocyte hypertrophy. The overexpression of miR-212 adenovirus was constructed, and the expression of miR-212 was overexpressed, and its effect on cardiac hypertrophy (CH) was detected by immunofluorescence and qRT-PCR. Then, the mechanism of miR-212 regulating CH was verified by website prediction, luciferase reporter gene assay, qRT-PCR, and western blotting assay. In the successfully constructed rat model of abdominal aortic constriction and cardiomyocyte hypertrophy, ANP and myh7 were dramatically increased, myh6 expression was decreased, and miRNA-212 expression was increased. Overexpression of miRNA-212 in cardiomyocytes can promote cardiomyocyte hypertrophy, while knocking down miR-212 in cardiomyocytes can partially reverse cell hypertrophy. In addition, miR-212 targets TCF7L2 and inhibits the expression of this gene. miRNA-212 targets TCF7L2 and inhibits the expression of this gene, possibly through this pathway to promote cardiomyocyte hypertrophy.<\/jats:p>","DOI":"10.1155\/2022\/5187218","type":"journal-article","created":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T05:20:43Z","timestamp":1661404843000},"page":"1-10","source":"Crossref","is-referenced-by-count":5,"title":["miR-212 Promotes Cardiomyocyte Hypertrophy through Regulating Transcription Factor 7 Like 2"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3494-2608","authenticated-orcid":true,"given":"Jinxia","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Cardiology, Shuyang Hospital of Traditional Chinese Medicine, Yangzhou University, Shuyang, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0734-5648","authenticated-orcid":true,"given":"Guoliang","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shuyang Hospital of Traditional Chinese Medicine, Yangzhou University, Shuyang, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.20452\/pamw.731"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra072139"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-9842(00)00141-0"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-007-9009-2"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccl.2013.09.015"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2016.11.034"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00041.2015"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2010.06.013"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.01.050"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3838"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.05.039"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2016.08.009"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00163.2011"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2261-13-12"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-10-0457"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2090"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.592362"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.13502"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2015.107"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S213910"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-72477-0_17"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.22498"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.11.071"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2011.03.007"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2015.07.022"}],"container-title":["Mediators of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2022\/5187218.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2022\/5187218.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2022\/5187218.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T05:20:46Z","timestamp":1661404846000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/mi\/2022\/5187218\/"}},"subtitle":[],"editor":[{"given":"Md Sayed","family":"Ali Sheikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,8,24]]},"references-count":25,"alternative-id":["5187218","5187218"],"URL":"https:\/\/doi.org\/10.1155\/2022\/5187218","relation":{},"ISSN":["1466-1861","0962-9351"],"issn-type":[{"value":"1466-1861","type":"electronic"},{"value":"0962-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8,24]]}}}