{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T13:24:47Z","timestamp":1776691487491,"version":"3.51.2"},"reference-count":60,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T00:00:00Z","timestamp":1643760000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009950","name":"Ministry of Education","doi-asserted-by":"publisher","award":["2018kfkt03"],"award-info":[{"award-number":["2018kfkt03"]}],"id":[{"id":"10.13039\/100009950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009950","name":"Ministry of Education","doi-asserted-by":"publisher","award":["16C0778"],"award-info":[{"award-number":["16C0778"]}],"id":[{"id":"10.13039\/100009950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009950","name":"Ministry of Education","doi-asserted-by":"publisher","award":["18A024"],"award-info":[{"award-number":["18A024"]}],"id":[{"id":"10.13039\/100009950","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Scientific Research Project of Hunan Provincial Education Department","award":["2018kfkt03"],"award-info":[{"award-number":["2018kfkt03"]}]},{"name":"Scientific Research Project of Hunan Provincial Education Department","award":["16C0778"],"award-info":[{"award-number":["16C0778"]}]},{"name":"Scientific Research Project of Hunan Provincial Education Department","award":["18A024"],"award-info":[{"award-number":["18A024"]}]},{"name":"Key Project of Education Department of Hunan Province","award":["2018kfkt03"],"award-info":[{"award-number":["2018kfkt03"]}]},{"name":"Key Project of Education Department of Hunan Province","award":["16C0778"],"award-info":[{"award-number":["16C0778"]}]},{"name":"Key Project of Education Department of Hunan Province","award":["18A024"],"award-info":[{"award-number":["18A024"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,2,2]]},"abstract":"<jats:p>\n                    Dysfunctional uterine bleeding, accompanied by endometrial hyperplasia (EH), is a common gynecological disease that seriously affects female physical and mental health. Some drugs have been prompted to cure the disease, but most medications have certain side effects and limitations. In the present study, we demonstrated an unexploited Chinese traditional medicine, a combination of Saururus chinensis, Celosia cristata, and Spatholobus suberectus (SCS), which could be used for the treatment of EH and associated complications in rats. We identified the active components from the three Chinese herbs via thin-layer chromatography and high-performance liquid chromatography methods. In addition, serum biochemical indexes and histologic section results found that acute high-dose SCS exerted no adverse impacts on the rats. We then showed that SCS shortened coagulation time (\n                    <jats:inline-formula>\n                      <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.018<\/a:mn>\n                      <\/a:math>\n                    <\/jats:inline-formula>\n                    ) and degree of swelling (\n                    <jats:inline-formula>\n                      <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.021<\/c:mn>\n                      <\/c:math>\n                    <\/jats:inline-formula>\n                    ) on rats at 30\u2009min compared to blank control. Further studies proved that recovered endometrial thickness was associated with the modulation of four hormones (follicle-stimulating hormone, luteinizing hormone, estrogen, and progesterone). Specifically, follicle-stimulating hormone and progesterone contents increased gradually with time, and estrogen was decreased, whereas luteinizing hormone content was returned to normal after a short-term elevation (\n                    <jats:inline-formula>\n                      <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>p<\/e:mi>\n                        <e:mo>&lt;<\/e:mo>\n                        <e:mn>0.05<\/e:mn>\n                      <\/e:math>\n                    <\/jats:inline-formula>\n                    ). Besides, SCS increased uterine endometrium\u2019s mRNA expression levels of matrix metalloproteinase-1 (\n                    <jats:inline-formula>\n                      <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>p<\/g:mi>\n                        <g:mo>&lt;<\/g:mo>\n                        <g:mn>0.001<\/g:mn>\n                      <\/g:math>\n                    <\/jats:inline-formula>\n                    ) and tissue inhibitor of matrix metalloproteinase-1 (\n                    <jats:inline-formula>\n                      <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>p<\/i:mi>\n                        <i:mo>&lt;<\/i:mo>\n                        <i:mn>0.001<\/i:mn>\n                      <\/i:math>\n                    <\/jats:inline-formula>\n                    ), promoting the repair of proliferating endometrium in the rats. Collectively, our study indicates that SCS harbors a profoundly curative effect on the treatment of EH and relative complications and uncovers the mechanism at molecular and gene expression levels.\n                  <\/jats:p>","DOI":"10.1155\/2022\/5200608","type":"journal-article","created":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T12:50:29Z","timestamp":1643806229000},"page":"1-13","source":"Crossref","is-referenced-by-count":4,"title":["A Traditional Chinese Medicine for the Treatment of Endometrial Hyperplasia via Regulating the HPO Axis in Rats"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2744-730X","authenticated-orcid":true,"given":"Bo","family":"Lv","sequence":"first","affiliation":[{"name":"Key Laboratory of Protein Chemistry and Developmental Biology of Fish of Ministry of Education, Hunan Normal University, Changsha 410081, 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of Fish of Ministry of Education, Hunan Normal University, Changsha 410081, China"},{"name":"Shaoyang University, Shaoyang 422000, Hunan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0752-323X","authenticated-orcid":true,"given":"Zhi","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Protein Chemistry and Developmental Biology of Fish of Ministry of Education, Hunan Normal University, Changsha 410081, 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