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Our research aims to explore the protective effects of Li\u2010ESWT in the aging rat model and its possible molecular mechanism through in vivo and in vitro experiments. In vitro, TM3 Leydig cells incubated with H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> were treated with Li\u2010ESWT at 4 energy levels (0.01, 0.05, 0.1, and 0.2\u2009mJ\/mm<jats:sup>2<\/jats:sup>). In vivo, we employed an androgen\u2010deficient rat model to simulate male aging and treated it with Li\u2010ESWT at three different energy levels (0.01, 0.05, and 0.2\u2009mJ\/mm<jats:sup>2<\/jats:sup>). Li\u2010ESWT increased the expression of vascular endothelial growth factor (VEGF) in TM3 cells, improved antioxidant capacity, and reduced apoptosis, with the effect being most significant at 0.05\u2009mJ\/mm<jats:sup>2<\/jats:sup> energy level. In androgen\u2010deficient rat model, LI\u2010ESWT can improve sperm count, motility, and serum testosterone level, enhancing tissue antioxidant capacity and antiapoptotic ability, and the effect is most significant at 0.05\u2009mJ\/mm<jats:sup>2<\/jats:sup> energy level. Therefore, Li\u2010ESWT at an appropriate energy level can improve sperm count, motility, and serum testosterone levels in androgen\u2010deficient rat models, reduce oxidative stress in the testis, and increase antioxidant capacity and antiapoptotic abilities. The mechanism of this condition might be related to the increased VEGF expression in Leydig cells by Li\u2010ESWT.<\/jats:p>","DOI":"10.1155\/2022\/5213573","type":"journal-article","created":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T21:50:53Z","timestamp":1647294653000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of Li\u2010ESWT on Testicular Tissue and Function in Androgen\u2010Deficient Rat Model"],"prefix":"10.1155","volume":"2022","author":[{"given":"Wen Jie","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Hwan","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyuk 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