{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T15:41:21Z","timestamp":1740152481042,"version":"3.37.3"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T00:00:00Z","timestamp":1661558400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008233","name":"School of Medicine, Shanghai Jiao Tong University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008233","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Oncology"],"published-print":{"date-parts":[[2022,8,27]]},"abstract":"<jats:p>Background. Esophageal squamous cell carcinoma (ESCC) is a common second primary neoplasia in patients with a history of head and neck squamous cell carcinoma (HNSCC). The aim of this study was to provide further information and novel insights into the risk factors for ESCC in patients with HNSCC. Methods. We retrospectively analyzed 98 HNSCC patients diagnosed from 2007 to 2017, 30 HNSCC patients suffering from ESCC, who had undergone endoscopic examination because of positive imaging examinations or symptoms, and 68 HNSCC patients who had no ESCC occurrence for at least six years post-HNSCC diagnosis. Associated clinicopathological data and lifestyle information of the ESCC group and the without ESCC group were collected, and a case-control study of risk factors was analyzed between the two groups. Results. The majority (83.4%) of the cases with HNSCC esophageal cancers were male patients over 50 years. We established that 93.75% (30\/32) of the ESCC occurred within six years after HNSCC diagnosis. HNSCC location, stage, and radiotherapy history had no significant association with the development of ESCC. High Ki67 labeling index (Ki67 LI) (&gt;46) patients tended to be 3.1 times (95% CI\u2009=\u20091.3\u20137.6) more likely to develop ESCC compared to low Ki67 LI (\u226445) patients (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). Drinkers with alcohol flushing response were at a 3.3 times higher risk to have ESCC (95% CI\u2009=\u20091.0\u201310.4) than drinkers without flush response (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.05<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). Conclusions. HNSCC patients, especially drinkers with an alcohol flushing response, as well as those with high Ki67 LI of HNSCC tissue, were more likely to develop ESCC.<\/jats:p>","DOI":"10.1155\/2022\/5227771","type":"journal-article","created":{"date-parts":[[2022,8,28]],"date-time":"2022-08-28T03:50:09Z","timestamp":1661658609000},"page":"1-6","source":"Crossref","is-referenced-by-count":0,"title":["Risk Factors for Esophageal Squamous Cell Carcinoma in Patients with Head and Neck Squamous Cell Carcinoma"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4663-2153","authenticated-orcid":true,"given":"Lei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Shanghai Ninth Peoples\u2019 Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China"},{"name":"Center for Digestive Diseases Research and Clinical Translation of Shanghai Jiao Tong University, Shanghai 200011, China"},{"name":"Shanghai Key Laboratory of Gut Microecology and Associated Major Diseases Research, Shanghai 200011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjing","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shanghai Ninth Peoples\u2019 Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China"},{"name":"Center for Digestive Diseases Research and Clinical Translation of Shanghai Jiao Tong University, Shanghai 200011, China"},{"name":"Shanghai Key Laboratory of Gut Microecology and Associated Major Diseases Research, Shanghai 200011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shanghai Ninth Peoples\u2019 Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China"},{"name":"Center for Digestive Diseases Research and Clinical Translation of Shanghai Jiao Tong University, Shanghai 200011, China"},{"name":"Shanghai Key Laboratory of Gut Microecology and Associated Major Diseases Research, Shanghai 200011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shanghai Ninth Peoples\u2019 Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China"},{"name":"Center for Digestive Diseases Research and Clinical Translation of Shanghai Jiao Tong University, Shanghai 200011, China"},{"name":"Shanghai Key Laboratory of Gut Microecology and Associated Major Diseases Research, Shanghai 200011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Shanghai Ninth Peoples\u2019 Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2184-9380","authenticated-orcid":true,"given":"Wei","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth Peoples\u2019 Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China"},{"name":"National Clinical Research Center for Oral Diseases, Shanghai 200011, China"},{"name":"Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai 200011, China"},{"name":"Research Unit of Oral and Maxillofacial Regenerative Medicine, Chinese Academy of Medical Sciences, Shanghai 200011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9657-0021","authenticated-orcid":true,"given":"Xiangjun","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shanghai Ninth Peoples\u2019 Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China"},{"name":"Center for Digestive Diseases Research and Clinical Translation of Shanghai Jiao Tong University, Shanghai 200011, China"},{"name":"Shanghai Key Laboratory of Gut Microecology and Associated Major Diseases Research, Shanghai 200011, 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