{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:49:25Z","timestamp":1747190965240,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T00:00:00Z","timestamp":1657497600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2022,7,11]]},"abstract":"<jats:p>Purpose. To determine the structure\u2013function relationship between cluster mean defect (MD) offered by standard automated perimetry and corresponding sector peripapillary retinal nerve fiber layer thickness (pRNFLT) measured with optical coherence tomography (OCT) in primary open angle glaucoma (POAG). Method. 39 healthy eyes (control group), 43 early POAG eyes (global MD\u2009\u2264\u20096\u2009dB, early group), 30 moderate POAG eyes (global MD between 6 and 12\u2009dB, moderate group), and 53 advanced POAG eyes (global MD\u2009&gt;\u200912\u2009dB, advanced group) underwent visual field (VF) examination with Octopus perimeter (dynamic strategy\/G2 pattern) and peripapillary retinal nerve fiber layer thickness measurements with RTVue-100 FD-OCT. Spearman analysis was used to investigate the correlation between cluster MDs provided by Octopus perimeter and corresponding sector pRNFLT for the total sample and each subgroup, respectively. Then, linear (y\u2009=\u2009a+\u2009bx) and curvilinear (quadratic, y\u2009=\u2009a+bx\u2009+\u2009cx2) regression analyses were employed to investigate the model for the cluster MD-sector pRNFLT pair with significant correlation. The strength of the relationship was characterized with correlation coefficient (\u03c1) and coefficient of determination (R2). For the cluster\u2013sector pair that could be fitted by both models, Wilcoxon signed rank test of absolute residuals was used to compare the goodness of fit. Results. Correlation between cluster MDs and corresponding sector pRNFLT was significant for all clusters in the total sample (\u03c1 values: \u22120.572 to 0.832, <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.001<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>) and in the POAG group (\u03c1 values: \u22120.551 to \u22120.777, <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.001<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). The highest \u03c1 values were found for cluster-sector pair 9 and pair 3, respectively. The curvilinear (quadratic) model provided better fit for all 10 cluster-sector pairs in the total sample (R2 values: 0.431\u20130.687, <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>&lt;<\/e:mo>\n                        <e:mn>0.001<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>) and in the POAG group (R2 values: 0.364\u20130.594, <jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                        <g:mo>&lt;<\/g:mo>\n                        <g:mn>0.01<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>). The highest R2 values were found also for cluster\u2013sector pair 9 and pair 3, respectively. In the control group, no significant correlation was found for any cluster\u2013sector pair (<jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>P<\/i:mi>\n                        <i:mo>&gt;<\/i:mo>\n                        <i:mn>0.01<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>). In the early group, correlation was significant for cluster\u2013sector pairs 3, 8, and 9 (\u03c1 values: \u22120.449, \u22120.627, and \u22120.815, resp., <jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mi>P<\/k:mi>\n                        <k:mo>&lt;<\/k:mo>\n                        <k:mn>0.01<\/k:mn>\n                     <\/k:math>\n                  <\/jats:inline-formula>). In the moderate group, correlation was significant for pairs 2, 3, 8, and 9 (\u03c1 values: \u22120.703, \u22120.556, \u22120.680, and \u22120.637, resp., <jats:inline-formula>\n                     <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <m:mi>P<\/m:mi>\n                        <m:mo>&lt;<\/m:mo>\n                        <m:mn>0.01<\/m:mn>\n                     <\/m:math>\n                  <\/jats:inline-formula>). In the advanced group, correlation was significant (<jats:inline-formula>\n                     <o:math xmlns:o=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\">\n                        <o:mi>P<\/o:mi>\n                        <o:mo>&lt;<\/o:mo>\n                        <o:mn>0.01<\/o:mn>\n                     <\/o:math>\n                  <\/jats:inline-formula>) for all 10 pairs (\u03c1 values: \u22120.395 to \u22120.699, <jats:inline-formula>\n                     <q:math xmlns:q=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\">\n                        <q:mi>P<\/q:mi>\n                        <q:mo>&lt;<\/q:mo>\n                        <q:mn>0.001<\/q:mn>\n                     <\/q:math>\n                  <\/jats:inline-formula>) except for pairs 2, 3, and 8, and the highest \u03c1 value was found for pair 1. For all cluster\u2013sector pairs with significant correlation in the early, moderate, and advanced groups, only linear model could be fitted (<jats:inline-formula>\n                     <s:math xmlns:s=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\">\n                        <s:mi>P<\/s:mi>\n                        <s:mo>&lt;<\/s:mo>\n                        <s:mn>0.01<\/s:mn>\n                     <\/s:math>\n                  <\/jats:inline-formula>), except for pair 9 in the early group and pair 5 in the advanced group. Conclusions. Cluster MD of the Octopus visual field showed significant moderate-to-strong negative correlation and curvilinear (quadratic) relationship with the corresponding sector pRNFLT for POAG. This type of regional structure\u2013function relationship varied according to the severity of POAG, and at each stage, the significantly correlated cluster\u2013sector pairs mainly showed linear relationship. The results could provide guidance for better utilization of this regional structure\u2013function method in the management of different stages of POAG.<\/jats:p>","DOI":"10.1155\/2022\/5231545","type":"journal-article","created":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T23:50:30Z","timestamp":1657583430000},"page":"1-10","source":"Crossref","is-referenced-by-count":1,"title":["Structure-Function Relationship between Cluster Mean Defect and Sector Peripapillary Retinal Nerve Fiber Layer Thickness in Primary Open Angle Glaucoma"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1595-2592","authenticated-orcid":true,"given":"Jing","family":"Han","sequence":"first","affiliation":[{"name":"Affiliated Hospital of Qingdao University, Qingdao, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8593-9727","authenticated-orcid":true,"given":"Wenjiu","family":"Yang","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Qingdao University, Qingdao, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7871-7330","authenticated-orcid":true,"given":"Dabo","family":"Wang","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Qingdao University, Qingdao, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7004-9705","authenticated-orcid":true,"given":"Haiqing","family":"Bai","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Qingdao University, Qingdao, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"4","key":"1","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/j.1442-9071.2012.02770.x","article-title":"\u2018Structure-function relationship\u2019 in glaucoma: past thinking and current concepts","volume":"40","author":"R. 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