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Gastrodin (GAS) is a phenolic glycoside extracted from the traditional Chinese herb\u2014Gastrodia elata\u2014and has been reported as a potential therapeutic agent for AD. However, its efficiency is reduced for AD patients due to its limited BBB permeability. Studies have demonstrated the feasibility of opening the blood-brain barrier (BBB) via focused ultrasound (FUS) to overcome the obstacles preventing medicines from blood flow into the brain tissue. We explored the therapeutic potential of FUS-mediated BBB opening combined with GAS in an AD-like mouse model induced by unilateral intracerebroventricular (ICV) injection of A\u03b21-42. Mice were divided into 5 groups: control, untreated, GAS, FUS and FUS+GAS. Combined treatment (FUS+GAS) rather than single intervention (GAS or FUS) alleviated memory deficit and neuropathology of AD-like mice. The time that mice spent in the novel arm was prolonged in the Y-maze test after 15-day intervention, and the waste-cleaning effect was remarkably increased. Contents of A\u03b2, tau, and P-tau in the observed (also the targeted) hippocampus were reduced. BDNF, synaptophysin (SYN), and PSD-95 were upregulated in the combined group. Overall, our results demonstrate that FUS-mediated BBB opening combined with GAS injection exerts the potential to alleviate memory deficit and neuropathology in the AD-like experimental mouse model, which may be a novel strategy for AD treatment.<\/jats:p>","DOI":"10.1155\/2022\/5241449","type":"journal-article","created":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T18:52:20Z","timestamp":1642099940000},"page":"1-13","source":"Crossref","is-referenced-by-count":36,"title":["Treatment Combining Focused Ultrasound with Gastrodin Alleviates Memory Deficit and Neuropathology in an Alzheimer\u2019s Disease-Like Experimental Mouse Model"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4692-4180","authenticated-orcid":true,"given":"Kaixuan","family":"Luo","sequence":"first","affiliation":[{"name":"School of Rehabilitation, Kunming Medical University, Kunming, Yunnan Province, 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