{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T21:45:22Z","timestamp":1792619122798,"version":"4.5.0"},"reference-count":19,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T00:00:00Z","timestamp":1645488000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005925","name":"Buddhist Tzu Chi Medical Foundation","doi-asserted-by":"publisher","award":["DTCRD109(2)-E-01"],"award-info":[{"award-number":["DTCRD109(2)-E-01"]}],"id":[{"id":"10.13039\/501100005925","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation","award":["DTCRD109(2)-E-01"],"award-info":[{"award-number":["DTCRD109(2)-E-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2022,2,22]]},"abstract":"<jats:p>Background. Chronic urticaria (CU) is comprised of diverse phenotypes, and thus, a shift towards a precision medical approach is warranted in its management. Methods. This study enrolled 78 patients with CU. Serum erythrocyte sedimentation rate, hemoglobin, hematocrit, eosinophil count, IgE, antinuclear antibody (ANA), and serum diamine oxidase (DAO) levels of the patients were measured and were compared according to the patient\u2019s response to second-generation antihistamines (sgAH), corticosteroids, leukotriene receptor antagonist (LTRA), H2 blockers, and low-histamine diet. Results. Age- and sex-adjusted logistic regression analysis showed that patients with duration of <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mtext>CU<\/a:mtext>\n                        <a:mo>&gt;<\/a:mo>\n                        <a:mn>3<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula> years (adjusted odd ratio <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mfenced open=\"[\" close=\"]\">\n                           <c:mrow>\n                              <c:mtext>aOR<\/c:mtext>\n                           <\/c:mrow>\n                        <\/c:mfenced>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>4.39<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>) and a <jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <g:mtext>DAO<\/g:mtext>\n                        <g:mtext>\u2009<\/g:mtext>\n                        <g:mtext>level<\/g:mtext>\n                        <g:mo>&lt;<\/g:mo>\n                        <g:mn>10<\/g:mn>\n                        <g:mtext>\u2009<\/g:mtext>\n                        <g:mtext>U<\/g:mtext>\n                        <g:mo>\/<\/g:mo>\n                        <g:mtext>mL<\/g:mtext>\n                     <\/g:math>\n                  <\/jats:inline-formula> (<jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <i:mtext>aOR<\/i:mtext>\n                        <i:mo>=<\/i:mo>\n                        <i:mn>3.90<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>) were significantly associated with a good sgAH response. <jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <k:mtext>Age<\/k:mtext>\n                        <k:mo>&gt;<\/k:mo>\n                        <k:mn>50<\/k:mn>\n                     <\/k:math>\n                  <\/jats:inline-formula> years (<jats:inline-formula>\n                     <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <m:mtext>aOR<\/m:mtext>\n                        <m:mo>=<\/m:mo>\n                        <m:mn>0.02<\/m:mn>\n                     <\/m:math>\n                  <\/jats:inline-formula>), duration of <jats:inline-formula>\n                     <o:math xmlns:o=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <o:mtext>chronic<\/o:mtext>\n                        <o:mtext>\u2009<\/o:mtext>\n                        <o:mtext>urticaria<\/o:mtext>\n                        <o:mo>&gt;<\/o:mo>\n                        <o:mn>3<\/o:mn>\n                     <\/o:math>\n                  <\/jats:inline-formula> years (aOR\u2009=0.06), and an <jats:inline-formula>\n                     <q:math xmlns:q=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\">\n                        <q:mtext>ANA<\/q:mtext>\n                        <q:mtext>\u2009<\/q:mtext>\n                        <q:mtext>titer<\/q:mtext>\n                        <q:mo>\u2265<\/q:mo>\n                        <q:mn>1<\/q:mn>\n                        <q:mo>:<\/q:mo>\n                        <q:mn>80<\/q:mn>\n                     <\/q:math>\n                  <\/jats:inline-formula> (<jats:inline-formula>\n                     <s:math xmlns:s=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\">\n                        <s:mtext>aOR<\/s:mtext>\n                        <s:mo>=<\/s:mo>\n                        <s:mn>0.03<\/s:mn>\n                     <\/s:math>\n                  <\/jats:inline-formula>) were significantly and inversely associated with corticosteroid response. A low-histamine diet response was significantly associated with LTRA response (<jats:inline-formula>\n                     <u:math xmlns:u=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\">\n                        <u:mtext>aOR<\/u:mtext>\n                        <u:mo>=<\/u:mo>\n                        <u:mn>67.29<\/u:mn>\n                     <\/u:math>\n                  <\/jats:inline-formula>). In addition, a DAO <jats:inline-formula>\n                     <w:math xmlns:w=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\">\n                        <w:mtext>level<\/w:mtext>\n                        <w:mo>&lt;<\/w:mo>\n                        <w:mn>5.4<\/w:mn>\n                        <w:mtext>\u2009<\/w:mtext>\n                        <w:mtext>U<\/w:mtext>\n                        <w:mo>\/<\/w:mo>\n                        <w:mtext>mL<\/w:mtext>\n                     <\/w:math>\n                  <\/jats:inline-formula> (<jats:inline-formula>\n                     <y:math xmlns:y=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M12\">\n                        <y:mtext>aOR<\/y:mtext>\n                        <y:mo>=<\/y:mo>\n                        <y:mn>71.95<\/y:mn>\n                     <\/y:math>\n                  <\/jats:inline-formula>) was significantly associated with H2 blocker response. Furthermore, concomitant angioedema (<jats:inline-formula>\n                     <ab:math xmlns:ab=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M13\">\n                        <ab:mtext>aOR<\/ab:mtext>\n                        <ab:mo>=<\/ab:mo>\n                        <ab:mn>10.56<\/ab:mn>\n                     <\/ab:math>\n                  <\/jats:inline-formula>), multiple food triggers (<jats:inline-formula>\n                     <cb:math xmlns:cb=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M14\">\n                        <cb:mtext>aOR<\/cb:mtext>\n                        <cb:mo>=<\/cb:mo>\n                        <cb:mn>11.69<\/cb:mn>\n                     <\/cb:math>\n                  <\/jats:inline-formula>), and a <jats:inline-formula>\n                     <eb:math xmlns:eb=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M15\">\n                        <eb:mtext>DAO<\/eb:mtext>\n                        <eb:mtext>\u2009<\/eb:mtext>\n                        <eb:mtext>level<\/eb:mtext>\n                        <eb:mo>&lt;<\/eb:mo>\n                        <eb:mn>5.4<\/eb:mn>\n                        <eb:mtext>\u2009<\/eb:mtext>\n                        <eb:mtext>U<\/eb:mtext>\n                        <eb:mo>\/<\/eb:mo>\n                        <eb:mtext>mL<\/eb:mtext>\n                     <\/eb:math>\n                  <\/jats:inline-formula> (<jats:inline-formula>\n                     <gb:math xmlns:gb=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M16\">\n                        <gb:mtext>aOR<\/gb:mtext>\n                        <gb:mo>=<\/gb:mo>\n                        <gb:mn>3.78<\/gb:mn>\n                     <\/gb:math>\n                  <\/jats:inline-formula>) were significantly associated with a low-histamine diet response. Conversely, dermatographic urticaria and a <jats:inline-formula>\n                     <ib:math xmlns:ib=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M17\">\n                        <ib:mtext>hematocrit<\/ib:mtext>\n                        <ib:mtext>\u2009<\/ib:mtext>\n                        <ib:mtext>level<\/ib:mtext>\n                        <ib:mo>&lt;<\/ib:mo>\n                        <ib:mn>36<\/ib:mn>\n                        <ib:mi>%<\/ib:mi>\n                     <\/ib:math>\n                  <\/jats:inline-formula> were significantly and inversely associated with low-histamine diet response. Conclusions. Several promising biomarkers were identified in this study to predict the efficacy of chronic urticaria treatment. DAO could be a novel biomarker for predicting the efficacy not only of dietary intervention but also for antagonists of H1 and H2 receptors.<\/jats:p>","DOI":"10.1155\/2022\/5243825","type":"journal-article","created":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T00:05:09Z","timestamp":1645574709000},"page":"1-7","source":"Crossref","is-referenced-by-count":12,"title":["Predictors of Response to Oral Medications and Low-Histamine Diet in Patients with Chronic Urticaria"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4749-2025","authenticated-orcid":true,"given":"Hui-Ling","family":"Chiang","sequence":"first","affiliation":[{"name":"Division of Immunology, Allergy and Rheumatology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Dalin, Chiayi, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Hung","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology and Rheumatology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, School of Medicine, Tzu Chi University, Hualien, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9242-9167","authenticated-orcid":true,"given":"Malcolm","family":"Koo","sequence":"additional","affiliation":[{"name":"Graduate Institute of Long-term Care, Tzu Chi University of Science and Technology, Hualien City, Hualien, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzung-Yi","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Dalin, Chiayi, Taiwan"},{"name":"Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan City, Taiwan"},{"name":"Department of Nursing, Tzu Chi University of Science and Technology, Hualien City, Hualien, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9260-727X","authenticated-orcid":true,"given":"Cheng-Han","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Immunology, Allergy and Rheumatology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Dalin, Chiayi, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12494"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1111\/all.13397"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2013.25.2.189"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1047"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-08593-9.00037-1"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2021.42.200088"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2019.08.025"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5615109"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.23822\/EurAnnACI.1764-1489.05"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1111\/all.12078"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1159\/000430442"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-011-1203-3"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2008.03110.x"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13966"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1177\/0394632015617170"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2015.01.009"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02130.x"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2015.1014120"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2005.11.010"}],"container-title":["Journal 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Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2022\/5243825.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2022\/5243825.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2022\/5243825.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T00:05:14Z","timestamp":1645574714000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/jir\/2022\/5243825\/"}},"subtitle":[],"editor":[{"given":"Liu","family":"Jinhui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,2,22]]},"references-count":19,"alternative-id":["5243825","5243825"],"URL":"https:\/\/doi.org\/10.1155\/2022\/5243825","relation":{},"ISSN":["2314-7156","2314-8861"],"issn-type":[{"value":"2314-7156","type":"electronic"},{"value":"2314-8861","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2,22]]}}}