{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T16:23:01Z","timestamp":1781886181970,"version":"3.54.5"},"reference-count":17,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,8,28]],"date-time":"2022-08-28T00:00:00Z","timestamp":1661644800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Emergency Medicine International"],"published-print":{"date-parts":[[2022,8,28]]},"abstract":"<jats:p>In recent years, the incidence of pneumonia caused by multidrug-resistant (MDR) Gram-negative bacteria (G\u2212) has increased year by year. Polymyxin B has a good clinical effect in the treatment of MDR, but there is controversy about the administration route of this drug. In this study, we retrospectively analyzed the clinical data of 84 cases of MDR Gram-negative bacterial pneumonia, and aimed to explore the effects of aerosol inhalation combined with intravenous polymyxin B infusion on the bacterial clearance, symptom improvement, and serum infection indexes of MDR patients on the patients with Gram-negative (G\u2212) bacterial pneumonia. The results show that aerosol inhalation combined with intravenous drip of polymyxin B can improve bacterial clearance rate, reduce levels of serum inflammatory factors, and improve clinical symptoms in patients with pneumonia induced by MDR G-bacteria.<\/jats:p>","DOI":"10.1155\/2022\/5244538","type":"journal-article","created":{"date-parts":[[2022,8,28]],"date-time":"2022-08-28T23:50:07Z","timestamp":1661730607000},"page":"1-6","source":"Crossref","is-referenced-by-count":10,"title":["Effects of Aerosol Inhalation Combined with Intravenous Drip of Polymyxin B on Bacterial Clearance, Symptoms Improvement, and Serum Infection Indexes in Patients with Pneumonia Induced by Multidrug-Resistant Gram-Negative Bacteria"],"prefix":"10.1155","volume":"2022","author":[{"given":"Hanlu","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Hospital of Chengdu University of Traditional Chinese Medicine, Chendu, Sichuan 610032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Hospital of Chengdu University of Traditional Chinese Medicine, Chendu, Sichuan 610032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4287-6129","authenticated-orcid":true,"given":"Pengfei","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Hospital of Chengdu University of Traditional Chinese Medicine, Chendu, Sichuan 610032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"3","key":"1","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1080\/1040841X.2019.1599813","article-title":"Antibiotic adjuvants: an alternative approach to overcome multi-drug resistant Gram-negative bacteria","volume":"45","author":"Y. 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