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Hemiplegic shoulder pain (HSP) is a common symptom for post-stroke patients, which has a severely adverse impact on their rehabilitation outcomes. However, the cause of HSP has not been clearly identified due to its complicated multifactorial etiologies. As possible causes of HSP, the abnormality of both muscular electrical activity and blood perfusion remains lack of investigations. Objective. This study aimed to analyze the alteration of muscular electrical activity and blood perfusion of upper extremity in patients with HSP by using surface electromyography (sEMG) and laser speckle contrast imaging (LSCI) measurement techniques, which may provide some insight into the etiology of HSP. Methods. In this observational and cross-sectional study, three groups of participants were recruited. They were hemiplegic patients with shoulder pain (HSP group), hemiplegic patients without shoulder pain (HNSP group), and healthy participants (Healthy group). The sEMG data and blood perfusion data were collected from all the subjects and used to compute three different physiological measures, the root-mean-square (RMS) and median-frequency (MDF) parameters of sEMG recordings, and the perfusion unit (PU) parameter of blood perfusion imaging. Results. The RMS parameter of sEMG showed significant difference (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>) in the affected side between HSP, HNSP, and Healthy groups. The MDF parameter of sEMG and PU parameter of blood perfusion showed no significant difference in both sides among the three groups (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                        <c:mo>&gt;<\/c:mo>\n                        <c:mn>0.05<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). The RMS parameter of sEMG showed a statistically significant correlation with the pain intensity (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>r<\/e:mi>\n                     <\/e:math>\n                  <\/jats:inline-formula>\u2009=\u2009-0.691, <jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>p<\/g:mi>\n                     <\/g:math>\n                  <\/jats:inline-formula>\u2009=0.012). Conclusion. This study indicated that the muscular electrical activity of upper extremity had a correlation with the presence of HSP, and the blood perfusion seemed to be no such correlation. The findings of the study suggested an alternative way to explore the mechanism and treatment of HSP.<\/jats:p>","DOI":"10.1155\/2022\/5253527","type":"journal-article","created":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T23:05:47Z","timestamp":1664319947000},"page":"1-11","source":"Crossref","is-referenced-by-count":3,"title":["Analysis of Muscular Electrical Activity and Blood Perfusion of Upper Extremity in Patients with Hemiplegic Shoulder Pain: A Pilot Study"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8767-3544","authenticated-orcid":true,"given":"Minghong","family":"Sui","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine, Huazhong University of Science and Technology Union Shenzhen Hospital (Shenzhen Nanshan People\u2019s Hospital), Shenzhen 518052, China"},{"name":"CAS Key Laboratory of Human-Machine Intelligence-Synergy Systems, Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), and the SIAT Branch, Shenzhen Institute of Artificial Intelligence and Robotics for Society, Shenzhen 518055, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7936-8446","authenticated-orcid":true,"given":"Naifu","family":"Jiang","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Human-Machine Intelligence-Synergy Systems, Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), and the SIAT Branch, Shenzhen Institute of Artificial Intelligence and Robotics for Society, Shenzhen 518055, China"},{"name":"Guangdong-HongKong-Macao Joint Laboratory of Human-Machine Intelligence-Synergy Systems, Shenzhen 518055, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5980-567X","authenticated-orcid":true,"given":"Luhui","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Huazhong University of Science and Technology Union Shenzhen Hospital (Shenzhen Nanshan People\u2019s Hospital), Shenzhen 518052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4566-9843","authenticated-orcid":true,"given":"Chenxi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Huazhong University of Science and Technology Union Shenzhen Hospital (Shenzhen Nanshan People\u2019s Hospital), Shenzhen 518052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8600-8932","authenticated-orcid":true,"given":"Jiaqing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Huazhong University of Science and Technology Union Shenzhen Hospital (Shenzhen Nanshan People\u2019s Hospital), Shenzhen 518052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1723-0681","authenticated-orcid":true,"given":"Tiebin","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9016-2617","authenticated-orcid":true,"given":"Guanglin","family":"Li","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Human-Machine Intelligence-Synergy Systems, Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), and the SIAT Branch, Shenzhen Institute of Artificial Intelligence and Robotics for Society, Shenzhen 518055, China"},{"name":"Guangdong-HongKong-Macao Joint Laboratory of Human-Machine Intelligence-Synergy Systems, Shenzhen 518055, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"8","key":"1","first-page":"514","article-title":"Shoulder pain in hemiplegia: statistical relationship with five variables","volume":"67","author":"R. 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