{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,23]],"date-time":"2025-11-23T03:08:28Z","timestamp":1763867308010,"version":"3.37.3"},"reference-count":46,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T00:00:00Z","timestamp":1642377600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI149793","AI124299","T32 HL007899","W81XWH-18-1-0717","P30 CA014520"],"award-info":[{"award-number":["AI149793","AI124299","T32 HL007899","W81XWH-18-1-0717","P30 CA014520"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["AI149793","AI124299","T32 HL007899","W81XWH-18-1-0717","P30 CA014520"],"award-info":[{"award-number":["AI149793","AI124299","T32 HL007899","W81XWH-18-1-0717","P30 CA014520"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI149793","AI124299","T32 HL007899","W81XWH-18-1-0717","P30 CA014520"],"award-info":[{"award-number":["AI149793","AI124299","T32 HL007899","W81XWH-18-1-0717","P30 CA014520"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014055","name":"U.S. Army Medical Research Acquisition Activity","doi-asserted-by":"publisher","award":["AI149793","AI124299","T32 HL007899","W81XWH-18-1-0717","P30 CA014520"],"award-info":[{"award-number":["AI149793","AI124299","T32 HL007899","W81XWH-18-1-0717","P30 CA014520"]}],"id":[{"id":"10.13039\/100014055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007923","name":"University of Wisconsin Carbone Cancer Center","doi-asserted-by":"publisher","award":["AI149793","AI124299","T32 HL007899","W81XWH-18-1-0717","P30 CA014520"],"award-info":[{"award-number":["AI149793","AI124299","T32 HL007899","W81XWH-18-1-0717","P30 CA014520"]}],"id":[{"id":"10.13039\/100007923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2022,1,17]]},"abstract":"<jats:p>The peptidylarginine deiminases (PADs) and the citrullinated proteins that they generate have key roles in innate immunity and rheumatoid arthritis, an inflammatory arthritis with antibodies that target citrullinated proteins. However, the importance of PADs, particularly PAD2, in the adaptive immune response, both normal and pathogenic, is newly emerging. In this study, we evaluated a requirement for PAD2 in the antibody response in collagen-induced arthritis (CIA), a T and B cell-driven murine model of rheumatoid arthritis, and in the protective antibody response to murine influenza infection. Using PAD2-\/- and PAD2+\/+ mice on the DBA\/1J background, we found that PAD2 is required for maximal anti-collagen antibody levels, but not collagen-specific plasma cell numbers, T cell activation or polarization, or arthritis severity in CIA. Also, we found that PAD2 is required not just for normal levels of persistent hemagglutination inhibiting antibodies but also for full protection from lethal influenza rechallenge. Together, these data provide evidence for a novel modest requirement for PAD2 in a normal antiviral antibody response and in an abnormal autoantibody response in inflammatory arthritis.<\/jats:p>","DOI":"10.1155\/2022\/5258221","type":"journal-article","created":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T00:20:24Z","timestamp":1642465224000},"page":"1-12","source":"Crossref","is-referenced-by-count":2,"title":["Peptidylarginine Deiminase 2 in Murine Antiviral and Autoimmune Antibody Responses"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8177-9161","authenticated-orcid":true,"given":"Aisha M.","family":"Mergaert","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA"},{"name":"Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael F.","family":"Denny","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brock","family":"Kingstad-Bakke","sequence":"additional","affiliation":[{"name":"Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandar","family":"Bawadekar","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Janna","family":"Bashar","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas F.","family":"Warner","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1794-3358","authenticated-orcid":true,"given":"Marulasiddappa","family":"Suresh","sequence":"additional","affiliation":[{"name":"Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8842-0303","authenticated-orcid":true,"given":"Miriam A.","family":"Shelef","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA"},{"name":"William S. Middleton Memorial Veterans Hospital, Madison, WI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.012211"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2011.151712"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.129687"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/2160192"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2017.01.006"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20100239"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12919"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-10-8965-7"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1316"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1002\/art.22983"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1038\/ng1206"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1002\/art.30235"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20123093"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0081259"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1002\/art.38393"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.11.6173"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1084\/jem.158.2.378"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-016-1055-2"},{"key":"19","doi-asserted-by":"crossref","first-page":"434","DOI":"10.4049\/jimmunol.115.2.434","article-title":"Host defenses against influenza virus: the role of anti-hemagglutinin antibody","volume":"115","author":"J. L. Virelizier","year":"1975","journal-title":"Journal of Immunology"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022043"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2016.06.020"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2020.101393"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21055"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006064"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.5.2917"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830160206"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.66.8.4647-4653.1992"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001620"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1800720"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900173"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1002\/art.20001"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1002\/art.24126"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003370"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1038\/srep26430"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.3.840"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1038\/nri891"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20021457"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00374-14"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004857"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.05930-11"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1007\/s12275-013-3428-7"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01305-15"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0227516"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.3390\/v20801530"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.1.277"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00514-09"}],"container-title":["Journal of Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2022\/5258221.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2022\/5258221.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2022\/5258221.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T08:42:00Z","timestamp":1674463320000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/jir\/2022\/5258221\/"}},"subtitle":[],"editor":[{"given":"Baohui","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,1,17]]},"references-count":46,"alternative-id":["5258221","5258221"],"URL":"https:\/\/doi.org\/10.1155\/2022\/5258221","relation":{},"ISSN":["2314-7156","2314-8861"],"issn-type":[{"type":"electronic","value":"2314-7156"},{"type":"print","value":"2314-8861"}],"subject":[],"published":{"date-parts":[[2022,1,17]]}}}