{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:49:51Z","timestamp":1747190991041,"version":"3.40.5"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T00:00:00Z","timestamp":1655769600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University","award":["YCXM20-01"],"award-info":[{"award-number":["YCXM20-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Oncology"],"published-print":{"date-parts":[[2022,6,21]]},"abstract":"<jats:p>We aim to investigate the correlation between the expression of estrogen-related receptor \u03b3 (ERR\u03b3) and endometrial cancer (EC) progression and to evaluate the potential of ERR\u03b3 as a new biomarker for EC diagnosis. We analyzed the ERR\u03b3 expression profile and the correlation with the corresponding clinical characteristics of EC samples from The Cancer Genome Atlas (TCGA), the Clinical Proteomic Tumor Analysis Consortium (CPTAC) databases, and the International Cancer Genome Consortium (ICGC) databases. Immunohistochemical (IHC) analysis was conducted on tissue samples, and enzyme linked immunosorbent assay (ELISA) was used in serum samples to detect the levels of ERR\u03b3. The diagnostic performance of ERR\u03b3 proteins was assessed using the receiver operating characteristic (ROC). ERR\u03b3 showed notably higher expression in EC tissues than in normal endometrium tissues (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.001<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>), which was consistent with the result of TCGA. Overexpression of ERR\u03b3 was significantly associated with deep myometrial invasion of EC (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.004<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>), and fasting blood glucose (FBG) was higher in EC patients with deep myometrial invasion than in those with superficial myometrial invasion (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>0.040<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>). Further analysis using ELISA showed that the serum ERR\u03b3 level was positively correlated with FBG (R\u2009=\u20090.355, <jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                        <g:mo>&lt;<\/g:mo>\n                        <g:mn>0.001<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>). ERR\u03b3 is overexpressed in EC and may be involved in regulating glucose metabolism and promoting myometrial invasion of EC. In addition, the area under the ROC curve (AUC) for ERR\u03b3 was 0.834, in distinguishing EC patients from healthy individuals, presented 84.0% and 80.0% sensitivity and specificity, respectively, and serum ERR\u03b3 has a good diagnostic performance in distinguishing EC patients from healthy people and may be a promising noninvasive biomarker in EC. <\/jats:p>","DOI":"10.1155\/2022\/5283388","type":"journal-article","created":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T03:35:08Z","timestamp":1655868908000},"page":"1-11","source":"Crossref","is-referenced-by-count":2,"title":["ERR\u03b3, a Novel Biomarker, Associates with Pathoglycemia of Endometrial Cancer to Predict Myometrial Invasion"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6987-8853","authenticated-orcid":true,"given":"Yao","family":"Tong","sequence":"first","affiliation":[{"name":"Department of Gynecology, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou 350001, China"},{"name":"Department of Gynecology, Fujian Obstetrics and Gynecology Hospital, Fuzhou 350001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0570-9989","authenticated-orcid":true,"given":"Meimei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou 350001, China"},{"name":"Department of Gynecology, Fujian Obstetrics and Gynecology Hospital, Fuzhou 350001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0438-8850","authenticated-orcid":true,"given":"Lili","family":"Chen","sequence":"additional","affiliation":[{"name":"Reproductive Center, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou 350001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8361-6799","authenticated-orcid":true,"given":"Huifang","family":"Lei","sequence":"additional","affiliation":[{"name":"Laboratory of Gynecologic Oncology, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou 350001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5551-3530","authenticated-orcid":true,"given":"Hao","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou 350001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8242-914X","authenticated-orcid":true,"given":"Xiaodan","family":"Mao","sequence":"additional","affiliation":[{"name":"Laboratory of Gynecologic Oncology, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou 350001, China"},{"name":"Key Laboratory of Women and Children\u2019s Critical Diseases Research, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou 350001, China"},{"name":"School of Medical Technology and Engineering, Fujian Medical University, No. 88 Jiaotong Road, Fuzhou 350004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5072-6091","authenticated-orcid":true,"given":"Pengming","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou 350001, China"},{"name":"Laboratory of Gynecologic Oncology, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou 350001, China"},{"name":"Key Laboratory of Women and Children\u2019s Critical Diseases Research, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou 350001, China"},{"name":"National Health Commission Key Laboratory of Technical Evaluation of Fertility Regulation for Non-human Primate, Jinjishan Road, Fuzhou 350005, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"1","key":"1","first-page":"7","article-title":"Cancer Statistics","volume":"71","author":"R. L. Siegel","year":"2021","journal-title":"CA: A Cancer Journal for Clinicians"},{"doi-asserted-by":"publisher","key":"2","DOI":"10.1016\/S0140-6736(15)00130-0"},{"doi-asserted-by":"publisher","key":"3","DOI":"10.3390\/cancers12051191"},{"doi-asserted-by":"publisher","key":"4","DOI":"10.1016\/j.ygyno.2014.01.032"},{"doi-asserted-by":"publisher","key":"5","DOI":"10.1200\/jco.2016.69.4638"},{"doi-asserted-by":"publisher","key":"6","DOI":"10.1016\/j.cmet.2016.03.005"},{"doi-asserted-by":"publisher","key":"7","DOI":"10.1016\/j.tem.2016.12.005"},{"doi-asserted-by":"publisher","key":"8","DOI":"10.1007\/s11010-019-03540-9"},{"doi-asserted-by":"publisher","key":"9","DOI":"10.1038\/emm.2015.115"},{"doi-asserted-by":"publisher","key":"10","DOI":"10.2147\/OTT.S79960"},{"doi-asserted-by":"publisher","key":"11","DOI":"10.1056\/nejmra1514010"},{"doi-asserted-by":"publisher","key":"12","DOI":"10.1200\/jco.2012.48.2596"},{"doi-asserted-by":"publisher","key":"13","DOI":"10.1016\/j.ygyno.2021.05.029"},{"doi-asserted-by":"publisher","key":"14","DOI":"10.1016\/j.ygyno.2022.01.013"},{"doi-asserted-by":"publisher","key":"15","DOI":"10.1038\/331091a0"},{"doi-asserted-by":"publisher","key":"16","DOI":"10.1186\/s13046-015-0150-9"},{"doi-asserted-by":"publisher","key":"17","DOI":"10.1021\/acschembio.0c00670"},{"doi-asserted-by":"publisher","key":"18","DOI":"10.1097\/cej.0000000000000052"},{"doi-asserted-by":"publisher","key":"19","DOI":"10.3892\/or.2018.6471"},{"doi-asserted-by":"publisher","key":"20","DOI":"10.1158\/1055-9965.epi-14-0923"},{"doi-asserted-by":"publisher","key":"21","DOI":"10.1007\/s12094-015-1309-8"},{"doi-asserted-by":"publisher","key":"22","DOI":"10.1016\/j.ygyno.2018.04.006"},{"doi-asserted-by":"publisher","key":"23","DOI":"10.1016\/j.stem.2015.03.001"},{"doi-asserted-by":"publisher","key":"24","DOI":"10.1038\/onc.2012.221"},{"doi-asserted-by":"publisher","key":"25","DOI":"10.2337\/db15-1523"},{"doi-asserted-by":"publisher","key":"26","DOI":"10.1016\/j.ygeno.2015.03.001"},{"doi-asserted-by":"publisher","key":"27","DOI":"10.1016\/j.cell.2008.08.021"},{"doi-asserted-by":"publisher","key":"28","DOI":"10.1111\/aogs.13847"}],"container-title":["Journal of Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jo\/2022\/5283388.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jo\/2022\/5283388.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jo\/2022\/5283388.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T03:35:19Z","timestamp":1655868919000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/jo\/2022\/5283388\/"}},"subtitle":[],"editor":[{"given":"Reza","family":"Izadpanah","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,6,21]]},"references-count":28,"alternative-id":["5283388","5283388"],"URL":"https:\/\/doi.org\/10.1155\/2022\/5283388","relation":{},"ISSN":["1687-8469","1687-8450"],"issn-type":[{"type":"electronic","value":"1687-8469"},{"type":"print","value":"1687-8450"}],"subject":[],"published":{"date-parts":[[2022,6,21]]}}}