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The effects of \u03b2-blockers in patients with unstable angina pectoris (UAP) are unclear. We tried to evaluate associations between \u03b2-blockers in UAP and long-term outcomes. Methods. We enrolled 5591 UAP patients and divided them into 2 groups based on \u03b2-blockers at discharge: 3790 did \u03b2-blockers and 1801 did not used them. Propensity score matching at 1\u2009:\u20091 was performed to select 1786 patients from each group. The primary endpoint was major adverse cardiac and cerebral events (MACCE) during the long-term follow-up period. Results. 67.8% of patients were on \u03b2-blockers at discharge; these patients were more likely to have CHD risk factors, lower ejection fraction, and severity of the coronary artery lesions. Over a median of 25.0 years, the incidence of MACCE was 25.5%. The risk was not significantly different between those on and those not on \u03b2-blocker treatment. The multivariate Cox regression analysis showed that no \u03b2-blocker use at discharge was not an independent risk factor for MACCE and sequence secondary endpoints. After propensity score matching, the results were similar. Conclusions. \u03b2-blocker use was not associated with lower MACCE and other secondary composite endpoints in long-term outcomes. This result adds to the increasing body of evidence that the routine prescription of \u03b2-blockers might not be indicated in patients with UAP. Trial registration had retrospectively registered.<\/jats:p>","DOI":"10.1155\/2022\/5287566","type":"journal-article","created":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T02:20:13Z","timestamp":1664504413000},"page":"1-13","source":"Crossref","is-referenced-by-count":2,"title":["Associations between \u03b2-Blocker Therapy at Discharge and Long-Term Follow-Up Outcomes in Patients with Unstable Angina Pectoris"],"prefix":"10.1155","volume":"2022","author":[{"given":"Lei","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Cardiology, Cardiovascular Center, Beijing Friendship Hospital, Capital Medical University, 95 Yongan Road, Beijing 100050, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaosong","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Center, Beijing Friendship Hospital, Capital Medical University, 95 Yongan Road, Beijing 100050, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Center, Beijing Friendship Hospital, Capital Medical University, 95 Yongan Road, Beijing 100050, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5534-5925","authenticated-orcid":true,"given":"Weiping","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Center, Beijing Friendship Hospital, Capital Medical University, 95 Yongan Road, Beijing 100050, China"},{"name":"Beijing Key Laboratory of Metabolic Disorder Related Cardiovascular Disease, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5900-7088","authenticated-orcid":true,"given":"Hongwei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Center, Beijing Friendship Hospital, Capital Medical University, 95 Yongan Road, Beijing 100050, China"},{"name":"Beijing Key Laboratory of Metabolic Disorder Related Cardiovascular Disease, Beijing, China"},{"name":"Department of Geriatrics, Cardiovascular Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-020-02314-y"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.04.052"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx393"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0000000000000133"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1056\/nejm198104023041401"},{"key":"6","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1016\/S0140-6736(99)04440-2","article-title":"Effect of metoprolol CR\/XL in chronic heart failure: metoprolol CR\/XL randomised intervention trial in congestive heart failure (MERIT-HF)","volume":"353","year":"1999","journal-title":"Lancet"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.02.013"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.06.004"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e318277d6a0"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1714\/1038.11322"},{"volume-title":"Endocrinology of the Heart in Health and Disease","year":"2017","author":"M. 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