{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T01:08:44Z","timestamp":1767834524269,"version":"3.49.0"},"reference-count":54,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T00:00:00Z","timestamp":1646179200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007015","name":"University of Wisconsin","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007015","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010284","name":"Herman and Gwendolyn Shapiro Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010284","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infectious Diseases in Obstetrics and Gynecology"],"published-print":{"date-parts":[[2022,3,2]]},"abstract":"<jats:p>Objective. To examine the relationship between documented \u03b2-lactam allergy and cesarean delivery (CD) surgical site infection (SSI). Study Design. We conducted a retrospective cohort analysis of women who underwent CD at Ben Taub Hospital and Texas Children\u2019s Pavilion for Women (Houston, TX) from August 1, 2011, to December 31, 2019. The primary exposure was a documented \u03b2-lactam allergy, and the second exposure of interest was the type of perioperative antibiotic received. The primary outcome was the prevalence of SSI. Maternal characteristics were stratified by the presence or absence of a documented \u03b2-lactam allergy, and significance was evaluated using Pearson\u2019s chi-squared test for categorical variables and <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>t<\/a:mi>\n                     <\/a:math>\n                  <\/jats:inline-formula>-test for continuous variables. A logistic regression model estimated odds of SSI after adjusting for possible confounders. Results. Of the 12,954 women included, 929 (7.2%) had a documented \u03b2-lactam allergy while 12,025 (92.8%) did not. Among the 929 women with a \u03b2-lactam allergy, 495 (53.3%) received non-\u03b2-lactam perioperative prophylaxis. SSI occurred in 38 (4.1%) of women who had a \u03b2-lactam allergy versus 238 (2.0%) who did not (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                        <c:mo>\u2264<\/c:mo>\n                        <c:mn>0.001<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). \u03b2-Lactam allergy was associated with higher odds of SSI compared to no allergy (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mtext>adjusted<\/e:mtext>\n                        <e:mtext>\u2009<\/e:mtext>\n                        <e:mtext>odds<\/e:mtext>\n                        <e:mtext>\u2009<\/e:mtext>\n                        <e:mtext>ratio<\/e:mtext>\n                        <e:mtext>\u2009<\/e:mtext>\n                        <e:mfenced open=\"(\" close=\")\">\n                           <e:mrow>\n                              <e:mtext>aOR<\/e:mtext>\n                           <\/e:mrow>\n                        <\/e:mfenced>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>1.97<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>; <jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <i:mn>95<\/i:mn>\n                        <i:mi>%<\/i:mi>\n                        <i:mtext>confidence<\/i:mtext>\n                        <i:mtext>\u2009<\/i:mtext>\n                        <i:mtext>interval<\/i:mtext>\n                        <i:mtext>\u2009<\/i:mtext>\n                        <i:mfenced open=\"(\" close=\")\">\n                           <i:mrow>\n                              <i:mtext>CI<\/i:mtext>\n                           <\/i:mrow>\n                        <\/i:mfenced>\n                        <i:mo>=<\/i:mo>\n                        <i:mn>1.24<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>-3.14; <jats:inline-formula>\n                     <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <m:mi>p<\/m:mi>\n                        <m:mo>=<\/m:mo>\n                        <m:mn>0.004<\/m:mn>\n                     <\/m:math>\n                  <\/jats:inline-formula>) after controlling for age, race, ethnicity, insurance status, delivery body mass index (BMI), tobacco use, intra-amniotic infection in labor, duration of membrane rupture, preterm delivery, delivery indication, diabetes, hypertension, group B Streptococcus colonization, and type of perioperative antibiotic received. Conclusion. The presence of a \u03b2-lactam allergy is associated with increased odds of developing a CD SSI after controlling for possible confounders, including the type of perioperative antibiotic received.<\/jats:p>","DOI":"10.1155\/2022\/5313948","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T16:50:27Z","timestamp":1646239827000},"page":"1-10","source":"Crossref","is-referenced-by-count":7,"title":["Documented \u03b2-Lactam Allergy and Risk for Cesarean Surgical Site Infection"],"prefix":"10.1155","volume":"2022","author":[{"given":"Courtney","family":"Johnston","sequence":"first","affiliation":[{"name":"University of Wisconsin School of Medicine and Public Health, 750 Highland Ave, Madison, WI 53726, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8681-7385","authenticated-orcid":true,"given":"Amy","family":"Godecker","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Wisconsin School of Medicine and Public Health, 1010 Mound Street Madison, WI 53715, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Shirley","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, University of Wisconsin School of Medicine and Public Health, 1685 Highland Avenue, 5158 Medical Foundation Centennial Building, Madison WI 53705-2281, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3537-8030","authenticated-orcid":true,"given":"Kathleen M.","family":"Antony","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Wisconsin School of Medicine and Public Health, 1010 Mound Street Madison, WI 53715, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1606187"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1685503"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix794"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.82a.14111"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.3390\/pharmacy7030094"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002863"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.15125"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp120568"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1097\/sla.0000000000003949"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/J.JAIP.2017.08.027"},{"issue":"3","key":"11","doi-asserted-by":"crossref","first-page":"e103","DOI":"10.1097\/AOG.0000000000002833","article-title":"ACOG Practice Bulletin No. 120: Use of prophylactic antibiotics in labor and delivery","volume":"132","author":"American College of Obstetricians and Gynecologists","year":"2018","journal-title":"Obstetrics & Gynecology"},{"key":"12","volume-title":"National Healthcare Safety Network (NHSN) Patient Safety Component Manual","author":"National Heathcare Safety Network","year":"2021"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2008.12.010"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2013.9763"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-019-4383-7"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1086\/657912"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.5435\/JAAOS-D-18-00709"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2019.374"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001899"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S98876"},{"key":"21","volume-title":"Statistical Brief - Most Frequent Procedures Performed in U.S. Hospitals, 2010. 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