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Hypertrophic cardiomyopathy (HCM) is a common genetic cardiovascular disorder. Studies have shown that HCM patients with COVID-19 have a higher mortality rate; however, the reason for this phenomenon is not yet elucidated. Herein, we conducted transcriptomic analyses to identify shared biomarkers between HCM and COVID-19 to bridge this knowledge gap. Differentially expressed genes (DEGs) were obtained using the Gene Expression Omnibus ribonucleic acid (RNA) sequencing datasets, GSE147507 and GSE89714, to identify shared pathways and potential drug candidates. We discovered 30 DEGs that were common between these two datasets. Using a combination of statistical and biological tools, protein-protein interactions were constructed in response to these findings to support hub genes and modules. We discovered that HCM is linked to COVID-19 progression based on a functional analysis under ontology terms. Based on the DEGs identified from the datasets, a coregulatory network of transcription factors, genes, proteins, and microRNAs was also discovered. Lastly, our research suggests that the potential drugs we identified might be helpful for COVID-19 therapy.<\/jats:p>","DOI":"10.1155\/2022\/5337380","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T00:50:10Z","timestamp":1664326210000},"page":"1-13","source":"Crossref","is-referenced-by-count":5,"title":["A Bioinformatic Approach Based on Systems Biology to Determine the Effects of SARS-CoV-2 Infection in Patients with Hypertrophic Cardiomyopathy"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6029-5854","authenticated-orcid":true,"given":"Xiao","family":"Han","sequence":"first","affiliation":[{"name":"Department of Cardiology, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3021-8409","authenticated-orcid":true,"given":"Ping","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Di","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangdong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunya","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Man","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaping","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangyi","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Vascular Disease, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-020-0360-5"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00023-07"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30251-8"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2020.1750954"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.03.031"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.06.007"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2021.09.066"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2021.04.001"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.61390"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.11122"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.047911"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.11296"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.25398"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq1184"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.04.026"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-15-293"},{"issue":"4","key":"18","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1089\/cmb.2015.0205","article-title":"Identification of differentially expressed genes in RNA-seq data of Arabidopsis thaliana: a compound distribution approach","volume":"23","author":"A. 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