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The aim of this study was to assess the role of prehospital point-of-care N-terminal probrain natriuretic peptide to predict sepsis, septic shock, or in-hospital sepsis-related mortality. Methods. A prospective, emergency medical service-delivered, prognostic, cohort study of adults evacuated by ambulance and admitted to emergency department between January 2020 and May 2021. The discriminative power of the predictive variable was assessed through a prediction model trained using the derivation cohort and evaluated by the area under the curve of the receiver operating characteristic on the validation cohort. Results. A total of 1,360 patients were enrolled with medical disease in the study. The occurrence of sepsis, septic shock, and in-hospital sepsis-related mortality was 6.4% (67 cases), 4.2% (44 cases), and 6.1% (64 cases). Prehospital National Early Warning Score 2 had superior predictive validity than quick Sequential Organ Failure Assessment and N-terminal probrain natriuretic peptide for detecting sepsis and septic shock, but N-terminal probrain natriuretic peptide outperformed both scores in in-hospital sepsis-related mortality estimation. Application of N-terminal probrain natriuretic peptide to subgroups of the other two scores improved the identification of sepsis, septic shock, and sepsis-related mortality in the group of patients with low-risk scoring. Conclusions. The incorporation of N-terminal probrain natriuretic peptide in prehospital care combined with already existing scores could improve the identification of sepsis, septic shock, and sepsis-related mortality.<\/jats:p>","DOI":"10.1155\/2022\/5351137","type":"journal-article","created":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T01:05:07Z","timestamp":1645664707000},"page":"1-13","source":"Crossref","is-referenced-by-count":8,"title":["Combination of Prehospital NT-proBNP with qSOFA and NEWS to Predict Sepsis and Sepsis-Related Mortality"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1773-2860","authenticated-orcid":true,"given":"Francisco","family":"Mart\u00edn-Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Unidad M\u00f3vil de Emergencias, Gerencia de Emergencias Sanitarias, Gerencia Regional de Salud de Castilla y Le\u00f3n (SACYL), Spain"},{"name":"Centro de Simulaci\u00f3n Cl\u00ednica Avanzada, Departamento de Medicina, 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