{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:23:14Z","timestamp":1767165794195,"version":"build-2238731810"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T00:00:00Z","timestamp":1653264000000},"content-version":"vor","delay-in-days":142,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    The renin\u2010angiotensin system (RAS) is involved in body fluid regulation, but one of its enzymes, angiotensin\u2010converting enzyme (ACE), indirectly causes hypertension by constricting blood vessels. Autoimmune illness is linked to the increased risk of hypertension and cardiovascular disease. In this study, ACE\u2010inhibiting peptides were studied from\n                    <jats:italic>Artemisia annua<\/jats:italic>\n                    proteins.\n                    <jats:italic>In silico<\/jats:italic>\n                    hydrolysis of proteins was performed by BIOPEP\u2010UWM using proteolytic enzymes from plant, microbial, and digestive sources. The physicochemical properties of 1160 peptides were determined using the peptide package of R studio. Di\u2010 and tripeptides were mostly released with a molecular weight of 170 to 350\u2009Da. PeptideRanker was used to select 16 peptides from a pool of 1160 peptides based on their likelihood of being bioactive. Molecular docking was performed by DS 2020 and AutoDock Vina, which revealed that the stability of the ligand\u2010receptor complex is due to hydrogen bonding and electrostatic and hydrophobic interactions. Their binding energies ranged from \u201031.81 to \u201020.09\u2009kJ\/mol. For drug\u2010likeness evaluation, an online tool SwissADME was used that follows the ADME rule (absorption, distribution, metabolism, and excretion) to check the pharmacokinetics and drug\u2010likeness of the compound. In the future, the released peptides can be used to make functional nutraceutical foods against hypertension.\n                  <\/jats:p>","DOI":"10.1155\/2022\/5367125","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T21:50:10Z","timestamp":1653342610000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["[Retracted] Exploration of ACE\u2010Inhibiting Peptides Encrypted in Artemisia annua Using In Silico Approach"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4417-7126","authenticated-orcid":false,"given":"Muhammad 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