{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T10:30:21Z","timestamp":1778581821909,"version":"3.51.4"},"reference-count":44,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T00:00:00Z","timestamp":1644364800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["108-2320-B-039-007"],"award-info":[{"award-number":["108-2320-B-039-007"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["CMRC-CMA-6"],"award-info":[{"award-number":["CMRC-CMA-6"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["CMU107-Z-05"],"award-info":[{"award-number":["CMU107-Z-05"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["DMR109-198"],"award-info":[{"award-number":["DMR109-198"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["DMR-110-010"],"award-info":[{"award-number":["DMR-110-010"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["DMR-110-188"],"award-info":[{"award-number":["DMR-110-188"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010002","name":"Ministry of Education","doi-asserted-by":"publisher","award":["108-2320-B-039-007"],"award-info":[{"award-number":["108-2320-B-039-007"]}],"id":[{"id":"10.13039\/100010002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010002","name":"Ministry of Education","doi-asserted-by":"publisher","award":["CMRC-CMA-6"],"award-info":[{"award-number":["CMRC-CMA-6"]}],"id":[{"id":"10.13039\/100010002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010002","name":"Ministry of Education","doi-asserted-by":"publisher","award":["CMU107-Z-05"],"award-info":[{"award-number":["CMU107-Z-05"]}],"id":[{"id":"10.13039\/100010002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010002","name":"Ministry of Education","doi-asserted-by":"publisher","award":["DMR109-198"],"award-info":[{"award-number":["DMR109-198"]}],"id":[{"id":"10.13039\/100010002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010002","name":"Ministry of Education","doi-asserted-by":"publisher","award":["DMR-110-010"],"award-info":[{"award-number":["DMR-110-010"]}],"id":[{"id":"10.13039\/100010002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010002","name":"Ministry of Education","doi-asserted-by":"publisher","award":["DMR-110-188"],"award-info":[{"award-number":["DMR-110-188"]}],"id":[{"id":"10.13039\/100010002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012544","name":"China Medical University, Taiwan","doi-asserted-by":"publisher","award":["108-2320-B-039-007"],"award-info":[{"award-number":["108-2320-B-039-007"]}],"id":[{"id":"10.13039\/501100012544","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012544","name":"China Medical University, Taiwan","doi-asserted-by":"publisher","award":["CMRC-CMA-6"],"award-info":[{"award-number":["CMRC-CMA-6"]}],"id":[{"id":"10.13039\/501100012544","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012544","name":"China Medical University, Taiwan","doi-asserted-by":"publisher","award":["CMU107-Z-05"],"award-info":[{"award-number":["CMU107-Z-05"]}],"id":[{"id":"10.13039\/501100012544","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012544","name":"China Medical University, Taiwan","doi-asserted-by":"publisher","award":["DMR109-198"],"award-info":[{"award-number":["DMR109-198"]}],"id":[{"id":"10.13039\/501100012544","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012544","name":"China Medical University, Taiwan","doi-asserted-by":"publisher","award":["DMR-110-010"],"award-info":[{"award-number":["DMR-110-010"]}],"id":[{"id":"10.13039\/501100012544","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012544","name":"China Medical University, Taiwan","doi-asserted-by":"publisher","award":["DMR-110-188"],"award-info":[{"award-number":["DMR-110-188"]}],"id":[{"id":"10.13039\/501100012544","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004391","name":"China Medical University Hospital","doi-asserted-by":"publisher","award":["108-2320-B-039-007"],"award-info":[{"award-number":["108-2320-B-039-007"]}],"id":[{"id":"10.13039\/501100004391","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004391","name":"China Medical University Hospital","doi-asserted-by":"publisher","award":["CMRC-CMA-6"],"award-info":[{"award-number":["CMRC-CMA-6"]}],"id":[{"id":"10.13039\/501100004391","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004391","name":"China Medical University Hospital","doi-asserted-by":"publisher","award":["CMU107-Z-05"],"award-info":[{"award-number":["CMU107-Z-05"]}],"id":[{"id":"10.13039\/501100004391","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004391","name":"China Medical University Hospital","doi-asserted-by":"publisher","award":["DMR109-198"],"award-info":[{"award-number":["DMR109-198"]}],"id":[{"id":"10.13039\/501100004391","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004391","name":"China Medical University Hospital","doi-asserted-by":"publisher","award":["DMR-110-010"],"award-info":[{"award-number":["DMR-110-010"]}],"id":[{"id":"10.13039\/501100004391","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004391","name":"China Medical University Hospital","doi-asserted-by":"publisher","award":["DMR-110-188"],"award-info":[{"award-number":["DMR-110-188"]}],"id":[{"id":"10.13039\/501100004391","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,2,9]]},"abstract":"<jats:p>Background. Knee osteoarthritis (KOA) is a chronic, low-grade inflammatory disease that affects knee joints and causes functional disability in the elderly. KOA is typically treated with oral NSAIDs, which are commonly associated with gastrointestinal side effects or cardiovascular complications. Traditional Chinese medicine (TCM) is widely used by patients with KOA in Taiwan; the Hu-Qian-Wan (HQW) formula is typically prescribed. We investigated the therapeutic role of a modified version of the HQW decoction in Sprague-Dawley rats with KOA induced by anterior cruciate ligament transection (ACLT) of the right knee. Materials and Methods. Thirty rats were randomly assigned to five groups (six animals each): arthrotomy alone (sham surgery, controls), ACLT only, ACLT\u2009+\u2009low-dose (1,000\u2009mg\/kg) HQW, ACLT\u2009+\u2009high-dose (3,000\u2009mg\/kg) HQW, and ACLT\u2009+\u2009celecoxib (30\u2009mg\/kg). All study groups underwent weight-bearing behavioral testing, micro-computed tomography (CT), and histological examinations of the knee joint cartilage, as well as immunohistochemical analyses of levels of interleukin (IL) 1\u03b2 and tumor necrosis factor (TNF) \u03b1 expression in articular cartilage. Results. At 6\u2009weeks, compared with ACLT group only, ACLT rats administered high-dose HQW or celecoxib exhibited the fewest weight-bearing deficits, the greatest improvements from baseline in articular cartilage architecture, and the lowest amounts of TNF-\u03b1 and IL-1\u03b2 staining in cartilage and synovial sections (all values were significant compared with the ACLT-only group). The only values that were significantly increased by ACLT\u2009+\u2009low-dose HQW compared with ACLT alone were bone mineral density and trabecular numbers. Conclusion. Our findings suggest that high-dose HQW improves weight-bearing asymmetry, decreases bone loss, and reduces levels of TNF-\u03b1 and IL-1\u03b2 in the affected joint in ACLT-induced KOA rats. More evidence is needed to support our findings.<\/jats:p>","DOI":"10.1155\/2022\/5367494","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T23:35:17Z","timestamp":1644449717000},"page":"1-10","source":"Crossref","is-referenced-by-count":6,"title":["The Traditional Chinese Medicine \u201cHu-Qian-Wan\u201d Attenuates Osteoarthritis-Induced Signs and Symptoms in an Experimental Rat Model of Knee Osteoarthritis"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4496-5870","authenticated-orcid":true,"given":"Pu-Wei","family":"Hou","sequence":"first","affiliation":[{"name":"Department of Chinese Medicine, China Medical University Hospital, Taichung 40447, Taiwan"},{"name":"Graduate Institute of Chinese Medicine, China Medical University, Taichung 40402, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan-Chi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medical Education and Research, China Medical University Beigang Hospital, Yunlin County 65152, Douliu, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory J.","family":"Tsay","sequence":"additional","affiliation":[{"name":"School of Medicine, China Medical University, Taichung 40402, Taiwan"},{"name":"Division of Immunology and Rheumatology, Department of Internal Medicine, China Medical University Hospital, Taichung 40447, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7113-8352","authenticated-orcid":true,"given":"Chih-Hsin","family":"Tang","sequence":"additional","affiliation":[{"name":"School of Medicine, China Medical University, Taichung 40402, Taiwan"},{"name":"Chinese Medicine Research Center, China Medical University, Taichung 40402, Taiwan"},{"name":"Department of Biotechnology, College of Health Science, Asia University, Taichung 41354, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7840-1504","authenticated-orcid":true,"given":"Hen-Hong","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Chinese Medicine, China Medical University Hospital, Taichung 40447, Taiwan"},{"name":"Chinese Medicine Research Center, China Medical University, Taichung 40402, Taiwan"},{"name":"Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2016.72","article-title":"Osteoarthritis","volume":"2","author":"J. Martel-Pelletier","year":"2016","journal-title":"Nature Reviews Disease Primers"},{"key":"2","article-title":"Global, regional prevalence, incidence and risk factors of knee osteoarthritis in population-based studies","volume":"29-30","author":"A. Cui","year":"2020","journal-title":"EClinicalMedicine"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/561459"},{"issue":"4","key":"4","doi-asserted-by":"crossref","first-page":"498","DOI":"10.12965\/jer.1938364.182","article-title":"Effects of kinesiotaping on knee osteoarthritis: a literature review","volume":"15","author":"M. Abolhasani","year":"2019","journal-title":"Journal of Exercise Rehabilitation"},{"issue":"7","key":"5","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/s41584-019-0237-3","article-title":"Establishing outcome measures in early knee osteoarthritis","volume":"15","author":"C. A. Emery","year":"2019","journal-title":"Nature Reviews Rheumatology"},{"issue":"11","key":"6","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1016\/j.joca.2019.06.011","article-title":"OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis","volume":"27","author":"R. R. Bannuru","year":"2019","journal-title":"Osteoarthritis and Cartilage"},{"key":"7","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.114147","article-title":"Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: a current perspective","volume":"180","author":"S. Bindu","year":"2020","journal-title":"Biochemical Pharmacology"},{"issue":"2","key":"8","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/art.41142","article-title":"2019 American college of rheumatology\/arthritis foundation guideline for the management of osteoarthritis of the hand, hip, and knee","volume":"72","author":"S. L. Kolasinski","year":"2020","journal-title":"Arthritis & Rheumatology"},{"key":"9","doi-asserted-by":"crossref","first-page":"e4","DOI":"10.1017\/erm.2018.3","article-title":"What has traditional Chinese medicine delivered for modern medicine?","volume":"20","author":"J. Wang","year":"2018","journal-title":"Expert Reviews in Molecular Medicine"},{"issue":"4","key":"10","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jtcme.2015.06.002","article-title":"Traditional Chinese medicine in patients with osteoarthritis of the knee","volume":"5","author":"P. W. Hou","year":"2015","journal-title":"Journal of Traditional and Complementary Medicine"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/2653792"},{"issue":"4","key":"12","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1142\/S0192415X16500373","article-title":"Traditional Chinese medications for knee osteoarthritis pain: a meta-analysis of randomized controlled trials","volume":"44","author":"B. Chen","year":"2016","journal-title":"The American Journal of Chinese Medicine"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0189884"},{"key":"14","volume-title":"Danxi Xinfa","author":"Z. Danxi"},{"issue":"4","key":"15","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0254-6272(15)30118-7","article-title":"Effect of Huqian Wan on liver-Yin and kidney-Yin deficiency patterns in patients with knee osteoarthritis","volume":"35","author":"C. Qiqing","year":"2015","journal-title":"Journal of Traditional Chinese Medicine"},{"issue":"4","key":"16","doi-asserted-by":"crossref","first-page":"957","DOI":"10.2165\/00003495-200059040-00017","article-title":"Celecoxib: a review of its use in osteoarthritis, rheumatoid arthritis and acute pain","volume":"59","author":"D. Clemett","year":"2000","journal-title":"Drugs"},{"key":"17","article-title":"Chondroprotective effects of ginsenoside Rg1 in human osteoarthritis chondrocytes and a rat model of anterior cruciate ligament transection","volume":"9","author":"W. Cheng","year":"2017","journal-title":"Nutrients"},{"issue":"5","key":"18","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1177\/0363546518756087","article-title":"Anterior cruciate ligament transection-induced cellular and extracellular events in menisci: implications for osteoarthritis","volume":"46","author":"J. Xie","year":"2018","journal-title":"The American Journal of Sports Medicine"},{"key":"19","article-title":"Apelin affects the progression of osteoarthritis by regulating VEGF-dependent angiogenesis and miR-150-5p expression in human synovial fibroblasts","volume":"9","author":"Y. H. Wang","year":"2020","journal-title":"Cells"},{"issue":"10","key":"20","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1016\/j.arthro.2016.02.011","article-title":"Effects of multiple intra-articular injections of 0.5% bupivacaine on normal and osteoarthritic joints in rats","volume":"32","author":"K. Iwasaki","year":"2016","journal-title":"Arthroscopy"},{"issue":"3","key":"21","first-page":"S623","article-title":"Bioactive turmerosaccharides from curcuma longa extract (NR-INF-02): potential ameliorating effect on osteoarthritis pain","volume":"13","author":"B. Bethapudi","year":"2016","journal-title":"Pharmacognosy Magazine"},{"issue":"8","key":"22","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1002\/jbm.b.33787","article-title":"Effect of osteoporosis on fixation of osseointegrated implants in rats","volume":"105","author":"Y. Li","year":"2017","journal-title":"Journal of Biomedical Materials Research Part B: Applied Biomaterials"},{"issue":"1","key":"23","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/jbmr.2926","article-title":"CCN1 promotes VEGF production in osteoblasts and induces endothelial progenitor cell angiogenesis by inhibiting miR-126 expression in rheumatoid arthritis","volume":"32","author":"C. Y. Chen","year":"2017","journal-title":"Journal of Bone and Mineral Research"},{"issue":"1","key":"24","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.taap.2015.08.020","article-title":"Berberine attenuates CCN2-induced IL-1beta expression and prevents cartilage degradation in a rat model of osteoarthritis","volume":"289","author":"S. C. Liu","year":"2015","journal-title":"Toxicology and Applied Pharmacology"},{"key":"25","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.joca.2005.07.014","article-title":"Osteoarthritis cartilage histopathology: grading and staging","volume":"14","author":"K. P. H. Pritzker","year":"2006","journal-title":"Osteoarthritis and Cartilage"},{"issue":"3","key":"26","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1016\/j.joca.2010.05.030","article-title":"The OARSI histopathology initiative\u2014recommendations for histological assessments of osteoarthritis in the rat","volume":"18","author":"N. Gerwin","year":"2010","journal-title":"Osteoarthritis and Cartilage"},{"key":"27","article-title":"Soya-cerebroside, an extract of Cordyceps militaris, suppresses monocyte migration and prevents cartilage degradation in inflammatory animal models","volume":"7","author":"S. C. Liu","year":"2017","journal-title":"Scientific Reports"},{"issue":"8","key":"28","article-title":"Brain-derived neurotrophic factor promotes VEGF-C-dependent lymphangiogenesis by suppressing miR-624-3p in human chondrosarcoma cells","volume":"8","author":"C. Y. Lin","year":"2017","journal-title":"Cell Death & Disease"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5190986"},{"key":"30","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.2147\/JPR.S247827","article-title":"Mechanism of traditional Chinese medicine in treating knee osteoarthritis","volume":"13","author":"M. Wang","year":"2020","journal-title":"Journal of Pain Research"},{"issue":"6","key":"31","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1111\/j.1747-0285.2012.01361.x","article-title":"Chemical components in extracts from Plastrum testudinis with proliferation-promoting effects on rat mesenchymal stem cells","volume":"79","author":"T. T. Wang","year":"2012","journal-title":"Chemical Biology & Drug Design"},{"issue":"2","key":"32","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.jep.2010.12.005","article-title":"Effect of Phellodendron amurense in protecting human osteoarthritic cartilage and chondrocytes","volume":"134","author":"J. H. Kim","year":"2011","journal-title":"Journal of Ethnopharmacology"},{"key":"33","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1475-2891-8-38","article-title":"Phellodendron and Citrus extracts benefit joint health in osteoarthritis patients: a pilot, double-blind, placebo-controlled study","volume":"8","author":"J. Oben","year":"2009","journal-title":"Nutrition Journal"},{"issue":"9","key":"34","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1007\/s12272-009-1916-4","article-title":"Timosaponin B-II inhibits pro-inflammatory cytokine induction by lipopolysaccharide in BV2 cells","volume":"32","author":"W. Q. Lu","year":"2009","journal-title":"Archives of Pharmacal Research"},{"issue":"1-2","key":"35","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0009-8981(03)00238-9","article-title":"Effect of Rehmannia glutinosa Libosch extracts on bone metabolism","volume":"334","author":"K. O. Oh","year":"2003","journal-title":"Clinica Chimica Acta"},{"key":"36","article-title":"Metabolomics profiling reveals Rehmanniae radix Preparata extract protects against glucocorticoid-induced osteoporosis mainly via intervening steroid hormone biosynthesis","volume":"24","author":"T. Xia","year":"2019","journal-title":"Molecules"},{"key":"37","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2019.107452","article-title":"Anti-inflammatory and immunoregulatory effects of paeoniflorin and total glucosides of paeony","volume":"207","author":"L. Zhang","year":"2020","journal-title":"Pharmacology & Therapeutics"},{"key":"38","article-title":"A review on the pharmacokinetics of paeoniflorin and its anti-inflammatory and immunomodulatory effects","volume":"130","author":"Y. X. Zhou","year":"2020","journal-title":"Biomedicine & Pharmacotherapy"},{"issue":"5","key":"39","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s00011-005-1345-x","article-title":"Effects and mechanisms of total glucosides of paeony on joint damage in rat collagen-induced arthritis","volume":"54","author":"L. Zhu","year":"2005","journal-title":"Inflammation Research"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/9689325"},{"issue":"1","key":"41","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s13065-017-0313-1","article-title":"Two phenolic antioxidants in Suoyang enhance viability of \u2022OH-damaged mesenchymal stem cells: comparison and mechanistic chemistry","volume":"11","author":"Y. Xie","year":"2017","journal-title":"Chemistry Central Journal"},{"key":"42","article-title":"Antioxidant capacity, anticancer ability and flavonoids composition of 35 citrus (Citrus reticulata Blanco) varieties","volume":"22","author":"Y. Wang","year":"2017","journal-title":"Molecules"},{"issue":"4","key":"43","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1089\/109662003772519877","article-title":"Effects of ginger (Zingiber officinale Rosc.) on decreasing the production of inflammatory mediators in sow osteoarthrotic cartilage explants","volume":"6","author":"C. L. Shen","year":"2003","journal-title":"Journal of Medicinal Food"},{"issue":"4","key":"44","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1097\/FPC.0b013e32834f94cb","article-title":"Celecoxib pathways: pharmacokinetics and pharmacodynamics","volume":"22","author":"L. Gong","year":"2012","journal-title":"Pharmacogenetics and Genomics"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/5367494.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/5367494.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/5367494.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T23:35:49Z","timestamp":1644449749000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ecam\/2022\/5367494\/"}},"subtitle":[],"editor":[{"given":"Md. Areeful","family":"Haque","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,2,9]]},"references-count":44,"alternative-id":["5367494","5367494"],"URL":"https:\/\/doi.org\/10.1155\/2022\/5367494","relation":{},"ISSN":["1741-4288","1741-427X"],"issn-type":[{"value":"1741-4288","type":"electronic"},{"value":"1741-427X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2,9]]}}}