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This study aimed to ascertain the immuno-inflammatory molecular targets of Xinfeng capsules (XFC) in the treatment of ankylosing spondylitis (AS) based on data mining, network pharmacology, and molecular docking. Methods. The efficacy of XFC in the treatment of AS was assessed by clinical data mining. Network pharmacology was utilized to establish a network of the targets for XFC active ingredients in the treatment of AS. The binding mode and affinity of XFC active ingredients to the key targets for AS were predicted using molecular docking. Results. XFC significantly diminished immuno-inflammatory indicators of AS. In total, 208 targets of XFC were obtained from the TCMSP database and 629 disease targets of AS were screened from the GeneCards database, which were intersected to yield 57 targets of XFC in the treatment of AS. Protein-protein interaction, gene ontology, and Kyoto genome encyclopedia analyses showed that XFC might activate TNF and NF-\u03baB signaling pathways. Quercetin, kaempferol, triptolide, and formononetin had free binding energies\u2009&lt;\u2009-9\u2009kcal\/mol to inflammatory targets (TNF and PTGS2) in the molecular docking analysis of XFC-active ingredients, indicating that TNF and PTGS2 might be the targets of the action of XFC. Conclusions. Collectively, XFC had a significant therapeutic effect on AS. Specifically, the active ingredients of XFC, including quercetin, kaempferol, triptolide, and formononetin, inhibited the inflammatory response in AS by downregulating TNF and PTGS2 in the TNF and NF-\u03baB signaling pathways.<\/jats:p>","DOI":"10.1155\/2022\/5382607","type":"journal-article","created":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T18:06:32Z","timestamp":1648058792000},"page":"1-10","source":"Crossref","is-referenced-by-count":8,"title":["Exploration of the Immuno-Inflammatory Potential Targets of Xinfeng Capsule in Patients with Ankylosing Spondylitis Based on Data Mining, Network Pharmacology, and Molecular Docking"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8754-7786","authenticated-orcid":true,"given":"Yanyan","family":"Fang","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui 230038, China"},{"name":"Key Laboratory of Xin\u2019an Medicine of the Ministry of Education, Anhui University of Chinese Medicine, Hefei, Anhui 230038, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3101-7553","authenticated-orcid":true,"given":"Jian","family":"Liu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui 230038, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9986-4551","authenticated-orcid":true,"given":"Ling","family":"Xin","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui 230038, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2757-8462","authenticated-orcid":true,"given":"Jianting","family":"Wen","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui 230038, China"},{"name":"Key Laboratory of Xin\u2019an Medicine of the Ministry of Education, Anhui University of Chinese Medicine, Hefei, Anhui 230038, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinchen","family":"Guo","sequence":"additional","affiliation":[{"name":"Anhui University of Chinese Medicine, Hefei, Anhui 230031, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9327-8583","authenticated-orcid":true,"given":"Dan","family":"Huang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui 230038, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Li","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui 230038, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.30498\/IJB.2021.2630"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2021.9961"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-02993-x"},{"issue":"1","key":"4","first-page":"80","article-title":"The role of sacroiliac joint steroid injections in the treatment of axial spondyloarthritis","volume":"36","author":"S. 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