{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:30:59Z","timestamp":1790641859402,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T00:00:00Z","timestamp":1657756800000},"content-version":"vor","delay-in-days":194,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012548","name":"Heilongjiang Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["LBH-Z18194"],"award-info":[{"award-number":["LBH-Z18194"]}],"id":[{"id":"10.13039\/100012548","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contrast Media &amp; Molecular Imaging"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>The abnormal proliferation, migration, and epithelial\u2010mesenchymal transformation (EMT) of lens epithelial cells (LECs) are the main reasons for vision loss caused by posterior capsular opacification (PCO) after cataract surgery. Insulin\u2010like growth factor\u20101 (IGF\u20101) was found to be associated with the pathogenesis of cataracts, but its biological role in PCO is poorly understood. In the present study, IGF\u20101 overexpression facilitated the proliferation, migration, and EMT, whereas knockdown of IGF\u20101 markedly suppressed the proliferation, migration, and TGF\u2010<jats:italic>\u03b2<\/jats:italic>2\u2010induced EMT of LECs. Additionally, to evaluate valuable microRNAs (miRNAs) which target IGF\u20101 to modulate LEC\u2010EMT, we predicted miR\u20103666 might regulate IGF\u20101 by binding its 3\u2019UTR according to the bioinformatics database. Furthermore, we verified that miR\u20103666 directly targeted IGF\u20101 by luciferase reporter assay. By using miR\u20103666 mimics, cell proliferation, migration, and invasion were suppressed, while being enhanced by the reduction of miR\u20103666. Knockout of IGF1 reverses the effect of the miR\u20103666 inhibitor on the malignant behavior of LECs. These results indicate the role of miR\u20103666\/IGF\u20101 in LEC\u2010EMT that offers new strategies for the therapy and prevention of PCO.<\/jats:p>","DOI":"10.1155\/2022\/5383146","type":"journal-article","created":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T20:20:10Z","timestamp":1657830010000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["[Retracted] IGF\u20101 Promotes Epithelial\u2010Mesenchymal Transition of Lens Epithelial Cells That Is Conferred by miR\u20103666 Loss"],"prefix":"10.1155","volume":"2022","author":[{"given":"Chao","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baowen","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8041-5756","authenticated-orcid":false,"given":"Zhan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,14]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.08.010804"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2018.0597"},{"key":"e_1_2_11_3_2","article-title":"Immediate sequential bilateral surgery versus delayed sequential bilateral surgery for cataracts","volume":"4","author":"Dickman Mor M.","year":"2022","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijo.IJO_291_21"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2010.09.012"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25797"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2015.02.004"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0000000000000441"},{"key":"e_1_2_11_9_2","article-title":"Non-steroidal anti-inflammatory drugs versus corticosteroids for controlling inflammation after uncomplicated cataract surgery","volume":"7","author":"Juthani V. V.","year":"2017","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_11_10_2","first-page":"949","article-title":"A complement receptor C5a antagonist regulates epithelial to mesenchymal transition and crystallin expression after lens cataract surgery in mice","volume":"17","author":"Maki R S.","year":"2011","journal-title":"Molecular Vision"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.18-23935"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.31999"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2014.06.004"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0178658"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1076\/ceyr.23.5.368.5441"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI19478"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1006\/exer.2000.0846"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-019-04833-4"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-10904"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2019.05.024"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12038-017-9709-2"},{"key":"e_1_2_11_22_2","first-page":"1030","article-title":"MicroRNA-3666 regulates thyroid carcinoma cell proliferation via MET. Cellular Physiology and Biochemistry: International Journal of Experimental Cellular Physiology","volume":"38","author":"Wang G.","year":"2016","journal-title":"Biochemistry, and Pharmacology"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.13273"},{"key":"e_1_2_11_24_2","first-page":"238","article-title":"LncRNA NNT-AS1 regulates the progression of lung cancer through the NNT-AS1\/miR-3666\/E2F2 axis","volume":"24","author":"Huang J. W.","year":"2020","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2016.152"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells8070656"},{"key":"e_1_2_11_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2008.01185.x"},{"key":"e_1_2_11_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0303-7207(90)90117-Q"},{"key":"e_1_2_11_29_2","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.933677"},{"key":"e_1_2_11_30_2","article-title":"IGF-1 Promotes Epithelial-Mesenchymal Transition of Lens Epithelial Cells that Is Conferred by miR-3666 Loss","author":"Shi Z.","year":"2021","journal-title":"ResearchSquare"}],"updated-by":[{"DOI":"10.1155\/2023\/9781567","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T00:00:00Z","timestamp":1689724800000},"record-id":"55335"},{"DOI":"10.1155\/2023\/9781567","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T00:00:00Z","timestamp":1689724800000}}],"container-title":["Contrast Media &amp; Molecular Imaging"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmi\/2022\/5383146.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmi\/2022\/5383146.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2022\/5383146","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T06:46:47Z","timestamp":1721803607000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2022\/5383146"}},"subtitle":[],"editor":[{"given":"Mohammad Farukh","family":"Hashmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1155\/2022\/5383146"],"URL":"https:\/\/doi.org\/10.1155\/2022\/5383146","archive":["Portico"],"relation":{"retraction":[{"id-type":"doi","id":"10.1155\/2023\/9781567","asserted-by":"object"}]},"ISSN":["1555-4309","1555-4317"],"issn-type":[{"value":"1555-4309","type":"print"},{"value":"1555-4317","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"2022-04-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"5383146"}}