{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T12:20:35Z","timestamp":1774268435722,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T00:00:00Z","timestamp":1645056000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sleep Disorders"],"published-print":{"date-parts":[[2022,2,17]]},"abstract":"Background. Acute hypercapnic respiratory failure (AHRF) is a common life-threatening event in patients with obesity hypoventilation syndrome (OHS). Objectives. To study the clinical pattern, noninvasive ventilatory support, as well as the short- and long-term outcomes of patients with OHS admitted in a ward because of AHRF. Methods. We conducted a retrospective cohort study including all adults with OHS \n \n aged<\/a:mtext>\n \u2265<\/a:mo>\n 18<\/a:mn>\n \u2212<\/a:mo>\n year<\/a:mtext>\n \u2212<\/a:mo>\n old<\/a:mtext>\n <\/a:math>\n <\/jats:inline-formula>, admitted in a 90-bed-ward for AHRF. Results. A total of 44 patients were included. Fifteen (34.1%) and 29 (65.9%) patients were diagnosed with malignant OHS (mOHS) and nonmalignant OHS (non-mOHS), respectively, while 36 (81.8%) had coexisting obstructive sleep apnea hypopnea syndrome (OSAHS). Patients with mOHS had a significantly higher rate of heart failure (100% vs. 31%; \n \n p<\/c:mi>\n <<\/c:mo>\n 0.001<\/c:mn>\n <\/c:math>\n <\/jats:inline-formula>), chronic renal insufficiency (CRI) (73.3% vs. 41.4%; \n \n p<\/e:mi>\n =<\/e:mo>\n 0.04<\/e:mn>\n <\/e:math>\n <\/jats:inline-formula>), and dyslipidemia (66.7% vs. 34.5%; \n \n p<\/g:mi>\n =<\/g:mo>\n 0.04<\/g:mn>\n <\/g:math>\n <\/jats:inline-formula>) than those with non-mOHS. The mean forced vital capacity (FVC) in our patients was of \n \n 59.5<\/i:mn>\n %<\/i:mi>\n \u00b1<\/i:mo>\n 18.5<\/i:mn>\n <\/i:math>\n <\/jats:inline-formula> of the predicted value, lower than what is usually reported in stable patients with OHS. At hospital admission, more than two-thirds (\n \n n<\/k:mi>\n =<\/k:mo>\n 34<\/k:mn>\n <\/k:math>\n <\/jats:inline-formula>, 77.3%) were misdiagnosed as having asthma exacerbation (\n \n n<\/m:mi>\n =<\/m:mo>\n 4<\/m:mn>\n <\/m:math>\n <\/jats:inline-formula>, 4.9.1%), chronic obstructive pulmonary disease (COPD) exacerbation (\n \n n<\/o:mi>\n =<\/o:mo>\n 12<\/o:mn>\n <\/o:math>\n <\/jats:inline-formula>, 27.3%) and\/or heart failure (\n \n n<\/q:mi>\n =<\/q:mo>\n 29<\/q:mn>\n <\/q:math>\n <\/jats:inline-formula>, 65.9%). Acute pulmonary oedema (ACPE) (\n \n n<\/s:mi>\n =<\/s:mo>\n 16<\/s:mn>\n <\/s:math>\n <\/jats:inline-formula>, 36.4%) and acute viral bronchitis (\n \n n<\/u:mi>\n =<\/u:mo>\n 12<\/u:mn>\n <\/u:math>\n <\/jats:inline-formula>, 27.3%) were the main identified causal factors, while no cause could be determined in 5 (11.4%) patients. Noninvasive positive pressure ventilation (NIPPV) using bilevel positive airway pressure (BIPAP) was very highly effective to treat AHRF, with only 2.27% of patients failing the modality. Median overall duration of ventilation was 9 hours per day (1.3\u201320) and was significantly longer in patients with mOHS than in those with non-mOHS (10 [6\u201318] vs. 8 [1.3\u201320], respectively; \n \n p<\/w:mi>\n =<\/w:mo>\n 0.01<\/w:mn>\n <\/w:math>\n <\/jats:inline-formula>). Forty two of the forty-three patients discharged alive were treated with BIPAP or continuous positive airway pressure (CPAP) in 26 and 16 patients, respectively. The probability of survival was 90% at 12 months, while the probability of readmission for a new episode of AHRF was 56% at 6 months and 22% at 12 months, respectively. Conclusion. AHRF in OHS patients is a life-threatening event which can be successfully and safely treated with BIPAP, with a low long-term mortality even in patients with mOHS.<\/jats:p>","DOI":"10.1155\/2022\/5398460","type":"journal-article","created":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T22:20:07Z","timestamp":1645136407000},"page":"1-13","source":"Crossref","is-referenced-by-count":3,"title":["Characteristics of Obese Patients with Acute Hypercapnia Respiratory Failure Admitted in the Department of Pneumology: An Observational Study of a North African Population"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2880-4548","authenticated-orcid":true,"given":"Sameh","family":"Msaad","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Sfax, Tunisia"},{"name":"Department of Respiratory and Sleep Medicine, Hedi Chaker University Hospital, Sfax, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3906-9457","authenticated-orcid":true,"given":"Rahma","family":"Gargouri","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Sfax, Tunisia"},{"name":"Department of Respiratory and Sleep Medicine, Hedi Chaker University Hospital, Sfax, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amina","family":"Kotti","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Sfax, Tunisia"},{"name":"Department of Respiratory and Sleep Medicine, Hedi Chaker University Hospital, Sfax, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0622-713X","authenticated-orcid":true,"given":"Nesrine","family":"Kallel","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Sfax, Tunisia"},{"name":"Department of Respiratory and Sleep Medicine, Hedi Chaker University Hospital, Sfax, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amel","family":"Saidane","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Sleep Medicine, Hedi Chaker University Hospital, Sfax, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yassine","family":"Jmal","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Sfax, Tunisia"},{"name":"Department of Respiratory and Sleep Medicine, Hedi Chaker University Hospital, Sfax, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wajdi","family":"Ketata","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Sfax, Tunisia"},{"name":"Department of Respiratory and Sleep Medicine, Hedi Chaker University Hospital, Sfax, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8807-8691","authenticated-orcid":true,"given":"Nadia","family":"Moussa","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Sfax, Tunisia"},{"name":"Department of Respiratory and Sleep Medicine, Hedi Chaker University Hospital, Sfax, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1632-5646","authenticated-orcid":true,"given":"Amine","family":"Bahloul","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Sfax, Tunisia"},{"name":"Department of Cardiology, Hedi Chaker University Hospital, Sfax, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samy","family":"Kammoun","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Sfax, Tunisia"},{"name":"Department of Respiratory and Sleep Medicine, Hedi Chaker University Hospital, Sfax, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1904-8744","authenticated-orcid":true,"given":"Jihene","family":"Jdidi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Sfax, Tunisia"},{"name":"Department of Preventive Medicine, Hedi Chaker University Hospital, Sfax, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"1","key":"1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12963-015-0035-3","article-title":"Abdominal vs. overall obesity among women in a nutrition transition context: geographic and socio-economic patterns of abdominal-only obesity in Tunisia","volume":"13","author":"P. 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