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Copper level has been proved to be closely related to the morbidity and mortality of cardiovascular diseases such as atherosclerosis, heart failure, and diabetic cardiomyopathy (DCM). Copper deficiency can induce cardiac hypertrophy and aggravate cardiomyopathy, while copper excess can mediate various types of cell death, such as autophagy, apoptosis, cuproptosis, pyroptosis, and cardiac hypertrophy and fibrosis. Both copper excess and copper deficiency lead to redox imbalance, activate inflammatory response, and aggravate diabetic cardiomyopathy. This defective copper metabolism suggests a specific metabolic pattern of copper in diabetes and a specific role in the pathogenesis and progression of DCM. This review is aimed at providing a timely summary of the effects of defective copper homeostasis on DCM and discussing potential underlying molecular mechanisms.<\/jats:p>","DOI":"10.1155\/2022\/5418376","type":"journal-article","created":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T22:35:08Z","timestamp":1664922908000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["The Molecular Mechanisms of Defective Copper Metabolism in Diabetic Cardiomyopathy"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4745-2384","authenticated-orcid":false,"given":"Xiangning","family":"Cui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjun","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0694-6804","authenticated-orcid":false,"given":"Jingwu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0562-3058","authenticated-orcid":false,"given":"Yifei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,4]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.316738"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0195796"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2016-310342"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.acvd.2021.08.004"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.314665"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.311586"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.120.315913"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-020-07099-2"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1039\/c9mt00223e"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.5.1468"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-009-1265-3"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.113.085068"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2021.03.054"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202108961"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1159\/000046013"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2007.06.061"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.2165\/11591370-000000000-00000"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2840-13-100"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.2174\/092986712800609715"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.9.2501"},{"key":"e_1_2_9_21_2","first-page":"129","article-title":"Urinary excretion of chromium, copper, and manganese in diabetes mellitus and associated disorders","volume":"18","author":"El-Yazigi A.","year":"1991","journal-title":"Diabetes Research"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2018.03.007"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)62949-5"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1139\/y00-054"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.4067\/S0717-95022022000100010"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0509929103"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2020.118867"},{"key":"e_1_2_9_28_2","volume-title":"StatPearls","author":"Lopez M. 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