{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T17:55:28Z","timestamp":1783792528392,"version":"3.55.0"},"reference-count":12,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T00:00:00Z","timestamp":1659657600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Rheumatology"],"published-print":{"date-parts":[[2022,8,5]]},"abstract":"<jats:p>Association of hypertrophic osteoarthropathy (HOA) with pulmonary tuberculosis is rarely reported, especially with smear-negative pulmonary tuberculosis (SNPT), in which its diagnosis is a challenge. We used a systematic approach to analyze all relevant literature reviews, and we identified only two cases of HOA associated with pulmonary tuberculosis in the last 10 years. We report the case of a 36-year-old man who presented with bilateral symmetric polyarthralgia and digital clubbing. Laboratory exams associated elevated acute phase reactants with negative immunological examinations. Two series of three acid-fast Bacillus (AFB) smear microscopy in sputum, separated by 15 days of broad-spectrum antibiotic therapy, were negative. A sputum culture was negative for Mycobacterium tuberculosis. A chest X-ray and computed tomography (CT) showed an apical pulmonary cavity. Plain X-ray and bone scintigraphy revealed periostosis of the tubular bones. Therefore, the diagnosis of HOA associated with probable SNPT was made. HOA symptoms had remitted after 3 months of antitubercular therapy. After 7 months of treatment, chest CT and bone scintigraphy showed a regression of the pulmonary cavity and disappearance of periostosis. The search for tuberculosis in front of any HOA seems to be justified in our epidemiological context.<\/jats:p>","DOI":"10.1155\/2022\/5429138","type":"journal-article","created":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T22:50:27Z","timestamp":1659739827000},"page":"1-4","source":"Crossref","is-referenced-by-count":1,"title":["Hypertrophic Osteoarthropathy Associated with Probable Smear-Negative Pulmonary Tuberculosis"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9852-7729","authenticated-orcid":true,"given":"Mohamed","family":"Ahmed Ghassem","sequence":"first","affiliation":[{"name":"Rheumatology Department, Military Hospital Mohammed V, Mohammed V University, Rabat, Morocco"},{"name":"Department of Internal Medicine, National Hospital Centre, Nouakchott, Mauritania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelhamid","family":"Biyi","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Military Hospital Mohammed V, Mohammed V University of Rabat, Rabat, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4297-9355","authenticated-orcid":true,"given":"Julien H","family":"Djossou","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Military Hospital Mohammed V, Mohammed V University, Rabat, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toufik","family":"Hamza","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Military Hospital Mohammed V, Mohammed V University, Rabat, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abderrahim","family":"Majjad","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Military Hospital Mohammed V, Mohammed V University, Rabat, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lahsen","family":"Achemlal","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Military Hospital Mohammed V, Mohammed V University, Rabat, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"3","key":"1","doi-asserted-by":"crossref","DOI":"10.1016\/j.berh.2020.101507","article-title":"Hypertrophic osteoarthropathy","volume":"34","author":"M. Mart\u00ednez-Lav\u00edn","year":"2020","journal-title":"Best Practice and Research Clinical Rheumatology"},{"issue":"7","key":"2","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1097\/JTO.0b013e3181dc1f3c","article-title":"Hypertrophic pulmonary osteoarthropathy as a paraneoplastic manifestation of lung cancer","volume":"5","author":"T. Ito","year":"2010","journal-title":"Journal of Thoracic Oncology"},{"issue":"3","key":"3","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1378\/chest.99.3.769","article-title":"Hypertrophic osteoarthropathy in association with pulmonary tuberculosis","volume":"99","author":"P. Kelly","year":"1991","journal-title":"Chest"},{"issue":"2","key":"4","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.pneumo.2009.11.001","article-title":"Hypertrophic osteoarthropathy associated with pulmonary tuberculosis","volume":"67","author":"I. 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Morel","year":"2020","journal-title":"Revue des Maladies Respiratoires"},{"issue":"1","key":"8","doi-asserted-by":"crossref","DOI":"10.1186\/s12879-019-4728-2","article-title":"Diagnosis of tuberculosis from smear-negative presumptive TB cases using Xpert MTB\/Rif assay: a cross-sectional study from Nepal","volume":"19","author":"P. Khadka","year":"2019","journal-title":"BMC Infectious Diseases"},{"key":"9","volume-title":"International Standards for Tuberculosis Care","author":"TB Care I","year":"2015","edition":"3rd"},{"issue":"4","key":"10","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.reuma.2014.10.008","article-title":"Hypertrophic osteoarthropathy as a complication of pulmonary tuberculosis","volume":"11","author":"M. C. 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Shih","year":"2004","journal-title":"Seminars in Nuclear Medicine"}],"container-title":["Case Reports in Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crirh\/2022\/5429138.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crirh\/2022\/5429138.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crirh\/2022\/5429138.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T22:50:36Z","timestamp":1659739836000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crirh\/2022\/5429138\/"}},"subtitle":[],"editor":[{"given":"Mario","family":"Salazar-Paramo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,8,5]]},"references-count":12,"alternative-id":["5429138","5429138"],"URL":"https:\/\/doi.org\/10.1155\/2022\/5429138","relation":{},"ISSN":["2090-6897","2090-6889"],"issn-type":[{"value":"2090-6897","type":"electronic"},{"value":"2090-6889","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8,5]]}}}