{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:16:18Z","timestamp":1792095378021,"version":"4.4.0"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T00:00:00Z","timestamp":1647907200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004697","name":"Hamadan University of Medical Sciences","doi-asserted-by":"publisher","award":["9602261184"],"award-info":[{"award-number":["9602261184"]}],"id":[{"id":"10.13039\/501100004697","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Pediatrics"],"published-print":{"date-parts":[[2022,3,22]]},"abstract":"<jats:p>\n                    Objectives. Neonatal jaundice or hyperbilirubinemia is one of the common findings in neonatal medicine. Severe disease can cause neurological damage and even Kernicterus. Magnesium ion is the most important N-methyl-D-aspartate receptor antagonist. The most commonly used treatment for jaundice is phototherapy, but the effect of phototherapy on serum magnesium is less investigated. In this study, we aim to investigate the effects of phototherapy on total serum magnesium levels in icteric neonates. Methods. This prospective cohort study was carried out on 160 neonates with jaundice referring to the Besat Hospital of Hamadan. Based on the bilirubin level, newborns were divided into three subgroups of mild, moderate, and severe disease which were subjected to single, double, and intensive phototherapy, respectively. Serum bilirubin and magnesium levels were measured before and after phototherapy and compared using parametric tests. Results. Subjects have a mean intrauterine age of 38.8 weeks and a jaundice onset age of 3.8 days. In all groups, serum magnesium levels were within the normal range before phototherapy. After phototherapy, on the other hand, the most reduction of total serum magnesium was in the double phototherapy group, which was\n                    <jats:inline-formula>\n                      <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mo>\u2212<\/a:mo>\n                        <a:mn>0.13<\/a:mn>\n                        <a:mo>\u00b1<\/a:mo>\n                        <a:mn>0.42<\/a:mn>\n                        <a:mtext>\u2009<\/a:mtext>\n                        <a:mtext>mg<\/a:mtext>\n                        <a:mo>\/<\/a:mo>\n                        <a:mtext>dl<\/a:mtext>\n                      <\/a:math>\n                    <\/jats:inline-formula>\n                    (\n                    <jats:inline-formula>\n                      <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.018<\/c:mn>\n                      <\/c:math>\n                    <\/jats:inline-formula>\n                    ). The change in serum magnesium level was not significant in the single phototherapy (\n                    <jats:inline-formula>\n                      <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mo>\u2212<\/e:mo>\n                        <e:mn>0.02<\/e:mn>\n                        <e:mo>\u00b1<\/e:mo>\n                        <e:mn>0.25<\/e:mn>\n                      <\/e:math>\n                    <\/jats:inline-formula>\n                    ) and intensive phototherapy (\n                    <jats:inline-formula>\n                      <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mo>\u2212<\/g:mo>\n                        <g:mn>13.55<\/g:mn>\n                        <g:mo>\u00b1<\/g:mo>\n                        <g:mn>2.73<\/g:mn>\n                      <\/g:math>\n                    <\/jats:inline-formula>\n                    ) groups (\n                    <jats:inline-formula>\n                      <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>P<\/i:mi>\n                        <i:mo>&gt;<\/i:mo>\n                        <i:mn>0.05<\/i:mn>\n                      <\/i:math>\n                    <\/jats:inline-formula>\n                    ). Conclusion. In the present study, serum magnesium did not increase significantly before the treatment in three groups. After treatment, a significant reduction was seen in the double phototherapy group.\n                  <\/jats:p>","DOI":"10.1155\/2022\/5439630","type":"journal-article","created":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T17:20:15Z","timestamp":1647969615000},"page":"1-5","source":"Crossref","is-referenced-by-count":6,"title":["Effects of Phototherapy on the Serum Magnesium Level in Neonates with Indirect Hyperbilirubinemia: A Prospective Cohort Study"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4668-3025","authenticated-orcid":true,"given":"Fatemeh","family":"Eghbalian","sequence":"first","affiliation":[{"name":"Division of Neonatology, Department of Pediatric, Besat Hospital, Hamadan University of Medical Sciences, Hamadan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somayeh","family":"Shabani","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5514-3584","authenticated-orcid":true,"given":"Javad","family":"Faradmal","sequence":"additional","affiliation":[{"name":"Modeling of Noncommunicable Diseases Research Center & Department of Biostatistics and Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4536-0814","authenticated-orcid":true,"given":"Ensiyeh","family":"Jenabi","sequence":"additional","affiliation":[{"name":"Autism Spectrum Disorders Research Center, Hamadan University of Medical Sciences, Hamadan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","first-page":"335","article-title":"Neonatal hyperbilirubinemia","volume-title":"Cloherty and Stark\u2019s Manual of Neonatal Care","author":"A. R. Stark","year":"2016","edition":"8th ed."},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2009.12.003"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.4103\/jcn.JCN_81_19"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-011-1454-1"},{"issue":"4","key":"5","first-page":"169","article-title":"Phototherapy-induced hypocalcemia in icteric newborns","volume":"27","author":"F. Eghbalian","year":"2015","journal-title":"Iranian Journal of Medical Sciences"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.4236\/health.2011.312119"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-007-0184-x"},{"issue":"4","key":"8","first-page":"349","article-title":"Effect of low versus moderate dose of clofibrate on serum bilirubin in healthy term neonates with indirect hyperbilirubinemia","volume":"38","author":"F. Eghbalian","year":"2013","journal-title":"Iranian Journal of Medical Sciences"},{"key":"9","first-page":"711","article-title":"Role of excitatory amino acid receptors in perinatal hypoxic-ischemic brain injury","volume-title":"Excitatory amino acid (6th edn), Fidia Research foundation symposium series","author":"M. V. Johnston","year":"1991","edition":"6th ed."},{"key":"10","volume-title":"Volpe\u2019s Neurology of the Newborn","author":"J. J. Volpe","year":"2018","edition":"6th ed."},{"issue":"6","key":"11","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1203\/00006450-199612000-00005","article-title":"The in vivo effect of bilirubin on the N-methyl-D-aspartate receptor\/ion channel complex in the brains of newborn piglets","volume":"40","author":"D. J. Hoffman","year":"1996","journal-title":"Pediatric Research"},{"key":"12","first-page":"432","article-title":"Total serum magnesium level in icteric neonates before and after phototherapy","volume":"69","author":"N. Khosravi","year":"2011","journal-title":"Tehran University Medical Journal"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000103874.01584.F3"},{"issue":"1","key":"14","first-page":"29","article-title":"Effect of phototherapy on serum bilirubin and ionzed magnesium level in hyper - bilirubinemic neonates","volume":"5","author":"N. K. Sapkota","year":"2017","journal-title":"Innovare Journal of Medical Sciences"},{"issue":"6","key":"15","first-page":"751","article-title":"Effect of phototherapy on serum magnesium level in term neonates with hyperbilirubinemia","volume":"57","author":"M. Ahmadpour-kacho","year":"2014","journal-title":"Medical Journal of Mashhad University of Medical Sciences"},{"key":"16","volume-title":"Pediatric Surgery: A Quick Guide to Decision-making","author":"S. R. Choudhury","year":"2017"},{"issue":"1&2","key":"17","first-page":"273","article-title":"Study of serum magnesium levels in neonatal jaundice: the effect of phototherapy","volume":"20","author":"M. S. E. Frargy","year":"2016","journal-title":"Current Pediatric Research"},{"issue":"8","key":"18","first-page":"761","article-title":"Trace metals in neonatal hyperbilirubinemia","volume":"25","author":"P. K. Misra","year":"1988","journal-title":"Indian Pediatrics"},{"issue":"3","key":"19","first-page":"357","article-title":"Effect of phototherapy on serum level of calcium, magnesium and vitamin D in infants with hyperbilirubinemia","volume":"13","author":"S. Shahriarpanah","year":"2018","journal-title":"Iranian Journal of Pathology"},{"issue":"2","key":"20","first-page":"4371","article-title":"Effect of intensive phototherapy and exchange transfusion on copper, zinc and magnesium serum levels in neonates with indirect hyperbilirubinemia","volume":"5","author":"A.-A. El-Mazary","year":"2017","journal-title":"International Journal Of Pediatrics"},{"issue":"95","key":"21","first-page":"16","article-title":"Total serum magnesium level in icteric neonates before and after phototherapy in patients admitted to 17 Shahrivar Hospital, Rasht, 2012-2013","volume":"24","author":"M. Karambin","year":"2015","journal-title":"Journal of Guilan University of Medical Sciences"}],"container-title":["International Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijpedi\/2022\/5439630.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijpedi\/2022\/5439630.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijpedi\/2022\/5439630.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T17:20:28Z","timestamp":1647969628000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ijpedi\/2022\/5439630\/"}},"subtitle":[],"editor":[{"given":"Samuel","family":"Menahem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,3,22]]},"references-count":21,"alternative-id":["5439630","5439630"],"URL":"https:\/\/doi.org\/10.1155\/2022\/5439630","relation":{},"ISSN":["1687-9759","1687-9740"],"issn-type":[{"value":"1687-9759","type":"electronic"},{"value":"1687-9740","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3,22]]}}}