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Twenty\u2010seven healthy male individuals (age: 25 \u00b1 4.3 years) participated in the study, including 18 RR\/RX and 9 XX individuals. The participants were divided into two groups (RR\/RX and XX groups) and subjected to an acute ST session, which consisted of a series of leg press, leg extension machine, and seated leg curl machine. The volunteers were instructed to perform the greatest volume of work until concentric muscle failure. Each volunteer\u2019s performance was analyzed as the load and total volume of training, and the blood concentrations of C\u2010C motif chemokine ligand 2 (CCL2), interleukin\u20108 (IL\u20108), creatine kinase (CK), lactate dehydrogenase (LDH), myoglobin, testosterone, and cortisol were measured before the ST session and 30\u2009min and 24\u2009h postsession. The ACTN3 R577X polymorphism effect was observed, with increased concentrations of CCL2 (<jats:italic>p<\/jats:italic> &lt; 0.01), IL\u20108 (<jats:italic>p<\/jats:italic> &lt; 0.01), and LDH (<jats:italic>p<\/jats:italic> &lt; 0.001) in XX individuals. There was an increase in the concentration of CK in the RR\/RX group compared to XX at 24\u2009h after training (<jats:italic>p<\/jats:italic> &gt; 0.01). The testosterone\/cortisol ratio increased more markedly in the XX group (<jats:italic>p<\/jats:italic> &lt; 0.001). Regarding performance, the RR\/RX group presented higher load and total volume values in the training exercises when compared to the XX group (<jats:italic>p<\/jats:italic> &lt; 0.05). However, the XX group presented higher values of delayed onset muscle soreness (DOMS) than the RR\/RX group (<jats:italic>p<\/jats:italic> &lt; 0.05). The influence of ACTN3 R577X polymorphism on muscle damage and the inflammatory response was observed after an acute ST session, indicating that the RR\/RX genotype shows more muscle damage and a catabolic profile due to a better performance in this activity, while the XX genotype shows more DOMS.<\/jats:p>","DOI":"10.1155\/2022\/5447100","type":"journal-article","created":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T18:50:08Z","timestamp":1671216608000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Influence of Alpha\u2010Actinin\u20103 R577X Polymorphism on Muscle Damage and the Inflammatory Response after an Acute Strength Training Session"],"prefix":"10.1155","volume":"2022","author":[{"given":"Milton 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