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A systematic search was conducted in PubMed, Scopus, Cochrane Library, and Web of Science among adult patients. Cohort and case\u2010control studies were included. Random\u2010effects models were used for meta\u2010analyses, and the effects were expressed as odds ratio (OR) and their 95% confidence intervals (CIs). We evaluated publication bias through Egger\u2019s test and funnel plot. <jats:italic>Results<\/jats:italic>. A total of 12 cohort studies and 26 case\u2010control studies were included, with 17076 patients. We found that the higher values of total cholesterol (TC), low\u2010density lipoprotein (LDL), triglycerides, and lipoprotein(a) (Lp(a)) were associated with a higher risk of developing DFU (OR: 1.47, OR: 1.47, OR: 1.5, OR: 1.85, respectively). Otherwise, the lower values of HDL were associated with a higher risk of developing DFU (OR: 0.49). Publication bias was not found for associations between TC, HDL, LDL, or TG and the risk of DFU. <jats:italic>Conclusions<\/jats:italic>. The high values of LDL, TC, TG, and Lp(a) and low values of HDL are associated with a higher risk of developing DFU. Furthermore, we did not find a significant association for VLDL, ApoA1, ApoB, and ApoB\/ApoA1 ratio.<\/jats:p>","DOI":"10.1155\/2022\/5450173","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T14:36:11Z","timestamp":1660142171000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Association between Lipid Profile and Apolipoproteins with Risk of Diabetic Foot Ulcer: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1093-4937","authenticated-orcid":false,"given":"Juan R.","family":"Ulloque-Badaracco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1386-7634","authenticated-orcid":false,"given":"Melany D.","family":"Mosquera-Rojas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1974-5200","authenticated-orcid":false,"given":"Enrique A","family":"Hernandez-Bustamante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3125-5949","authenticated-orcid":false,"given":"Esteban A","family":"Alarc\u00f3n-Braga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1298-5225","authenticated-orcid":false,"given":"Ricardo R.","family":"Ulloque-Badaracco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3718-5857","authenticated-orcid":false,"given":"Ali","family":"Al-kassab-C\u00f3rdova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Percy","family":"Herrera-A\u00f1azco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9158-1108","authenticated-orcid":false,"given":"Vicente A.","family":"Benites-Zapata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian V.","family":"Hernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,10]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.DIABRES.2019.107843"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13047-020-00433-9"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2016.1231932"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/J.SEMVASCSURG.2019.02.001"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.7754\/CLIN.LAB.2014.140209"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.BBALIP.2019.01.005"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/S12933-018-0781-1"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.2337\/DIACARE.26.2.491"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/2042018817744513"},{"key":"e_1_2_9_10_2","first-page":"373","article-title":"Prevention of diabetic foot ulcer","volume":"4","author":"Iraj B.","year":"2013","journal-title":"International Journal of Preventive Medicine"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/JCLA.23719"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1101\/2020.06.11.20128488"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8227(96)01232-6"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.JDIACOMP.2014.04.002"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_9_16_2","unstructured":"Cochrane Handbook for systematic reviews of Interventions | Cochrane Training 2021 https:\/\/training.cochrane.org\/handbook Accessed."},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/S13643-016-0384-4"},{"key":"e_1_2_9_18_2","unstructured":"WellsG. 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