{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T02:09:19Z","timestamp":1762999759316,"version":"3.40.5"},"reference-count":18,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T00:00:00Z","timestamp":1661731200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Tianjin Key Medical Discipline (Specialty) Construction Project","award":["TJYXZDXK-063B"],"award-info":[{"award-number":["TJYXZDXK-063B"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Respiratory Journal"],"published-print":{"date-parts":[[2022,8,29]]},"abstract":"<jats:p>Objectives. Viral load is important when evaluating viral transmission potential, involving the use of a polymerase chain reaction (PCR) cycle threshold (Ct) value. We aimed to analyze the PCR Ct values of respiratory tract samples taken from patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant strains to evaluate these strains\u2019 viral dynamics. Methods. This study comprised 361 patients. The Ct values of SARS-CoV-2-related respiratory samples were compared between symptomatic and asymptomatic patients. Results. The median (25th percentile and 75th percentile) nasopharynx and oropharynx SARS-CoV-2 Ct values were 30.5 (24.5\u201335.0) and 34.5 (30.0\u201337.0) in the symptomatic group, respectively, and 27.8 (23.4\u201334.5) and 33.5 (26.0\u201335.0) in the asymptomatic group, respectively, without significance. In the symptomatic group, subgroup analyses according to age showed the mean nasal Ct value for patients aged &gt;18 years was 29.0 (23.5\u201334.5), which was significantly lower than that of patients aged 0\u20134 years and 5\u201313 years (36.0 (30.5\u201338.0) and 34.5 (31.0\u201339.0), respectively). The nasal Ct value for asymptomatic patients aged &gt;18 years was 25.5 (20.9\u201328.4), which was significantly lower than of patients aged 5\u201313 years (34.5 (25.6\u201336.4)). Conclusion. Our findings suggest that the viral loads of asymptomatic and symptomatic patients did not differ significantly. However, adults infected with SARS-CoV-2 had higher nasal viral loads that those of young children.<\/jats:p>","DOI":"10.1155\/2022\/5460400","type":"journal-article","created":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T01:20:30Z","timestamp":1661822430000},"page":"1-6","source":"Crossref","is-referenced-by-count":9,"title":["Viral RNA Load in Symptomatic and Asymptomatic COVID-19 Omicron Variant-Positive Patients"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4693-3159","authenticated-orcid":true,"given":"Qian","family":"Wu","sequence":"first","affiliation":[{"name":"Haihe Clinical School, Tianjin Medical University, Tianjin, China"},{"name":"Department of Respiratory Medicine, Haihe Hospital, Tianjin University, Tianjin, China"},{"name":"Tianjin Institute of Respiratory Diseases, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2814-9600","authenticated-orcid":true,"given":"Lixia","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Haihe Hospital, Tianjin University, Tianjin, China"},{"name":"Department of Medicine, Haihe Hospital, Tianjin University, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6068-5660","authenticated-orcid":true,"given":"Haomin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Tianjin Hospital, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2792-4126","authenticated-orcid":true,"given":"Shuping","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Medicine, Haihe Hospital, Tianjin University, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7323-7170","authenticated-orcid":true,"given":"Hongwei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Haihe Hospital, Tianjin University, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2542-2392","authenticated-orcid":true,"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Haihe Hospital, Tianjin University, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2360-1290","authenticated-orcid":true,"given":"Jin","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Medicine, Haihe Hospital, Tianjin University, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8172-649X","authenticated-orcid":true,"given":"Qi","family":"Wu","sequence":"additional","affiliation":[{"name":"Haihe Clinical School, Tianjin Medical University, Tianjin, China"},{"name":"Tianjin Institute of Respiratory Diseases, Tianjin, China"},{"name":"Department of Respiratory Medicine, Tianjin Medical University General Hospital, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8139-0084","authenticated-orcid":true,"given":"Zhengcun","family":"Pei","sequence":"additional","affiliation":[{"name":"Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"volume-title":"Classification of Omicron (B.1.1.529): SARS-CoV-2 Variant of Concern","year":"2021","author":"World Health Organization","key":"1"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1002\/gch2.1018"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(21)01755-4"},{"article-title":"Active epidemiological investigation on SARS-CoV-2 infection caused by omicron variant (Pango lineage B.1.1.529) in Japan: Preliminary report on infectious period","year":"2022","author":"National Institute of Infectious Diseases Disease","key":"4"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.o89"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.7554\/elife.64683"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.02593-20"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1101\/2020.08.18.20166835"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa638"},{"issue":"4","key":"10","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1093\/cid\/ciaa991","article-title":"Presymptomatic Transmission of severe acute respiratory syndrome coronavirus 2 among residents and staff at a skilled nursing facility: results of real-time polymerase chain reaction and serologic testing","volume":"72","author":"S. 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