{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T11:55:00Z","timestamp":1792410900560,"version":"4.4.0"},"reference-count":77,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,15]],"date-time":"2022-10-15T00:00:00Z","timestamp":1665792000000},"content-version":"vor","delay-in-days":287,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    Alzheimer\u2019s disease (AD) is a neurodegenerative disorder characterized by behavioral and psychological symptoms in addition to cognitive impairment and loss of memory. The exact pathogenesis and genetic background of AD are unclear and there remains no effective treatment option. Sarcosine, an n\u2010methyl derivative of glycine, showed a promising therapeutic strategy for some cognitive disorders. To our knowledge, the impacts of sarcosine supplementation against AD have not yet been elucidated. Therefore, we aimed to determine the neuroprotective potential of sarcosine in\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    AD model.\n                    <jats:italic>In vitro<\/jats:italic>\n                    studies have demonstrated that sarcosine increased the percentage of viable cells against aluminum induced neurotoxicity. In AlCl\n                    <jats:sub>3<\/jats:sub>\n                    \u2010induced rat model of AD, the level of antioxidant capacity was significantly decreased and expression levels of\n                    <jats:italic>APP<\/jats:italic>\n                    ,\n                    <jats:italic>BACE1<\/jats:italic>\n                    ,\n                    <jats:italic>TNF-\u03b1<\/jats:italic>\n                    ,\n                    <jats:italic>APH1A,<\/jats:italic>\n                    and\n                    <jats:italic>PSENEN<\/jats:italic>\n                    genes were elevated compared to the control group. Additionally, histopathological examinations of the hippocampus of AlCl\n                    <jats:sub>3<\/jats:sub>\n                    \u2010induced rat brains showed the presence of neurofibrillary tangles (NFTs). However, the administration of sarcosine produced marked improvement and protection of AD\u2010associated pathologies induced by AlCl\n                    <jats:sub>3<\/jats:sub>\n                    in experimental rats. Therefore, this investigation may contribute to design novel therapeutic strategies using sarcosine for the management of AD pathologies.\n                  <\/jats:p>","DOI":"10.1155\/2022\/5467498","type":"journal-article","created":{"date-parts":[[2022,10,15]],"date-time":"2022-10-15T12:50:05Z","timestamp":1665838205000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["<i>In Vitro<\/i>\n                    and\n                    <i>In Vivo<\/i>\n                    Neuroprotective Effects of Sarcosine"],"prefix":"10.1155","volume":"2022","author":[{"given":"Arzug\u00fcl","family":"Tanas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5472-8174","authenticated-orcid":false,"given":"\u00d6zlem \u00d6zdemir","family":"Tozlu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tu\u011fba","family":"Gezmi\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Hacim\u00fcft\u00fco\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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