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It has been found that Callicarpa nudiflora (CN) as an air-dried leaf extract has a broad-spectrum antibacterial effect. This study aims to examine the effect of CN on H. pylori-infected GES-1 cells in vitro and elucidate its underlying mechanism by extracting active ingredients from air-dried leaves. GES-1\u2009cells were cocultured with HPSS1 at MOI\u2009=\u2009100\u2009:\u20091 and treated with different concentrations of CN (100 and 200\u2009\u03bcg\/ml). Results showed that CN can significantly reduce cellular LDH leakage and attenuate H. pylori-induced cell apoptosis and ROS production in GSE-1 cells, so as to protect gastric epithelial cells from damage by H. pylori. CN can also inhibit the secretion of inflammatory factors, such as TNF-\u03b1, IL-1\u03b2, IL-6, and IL-8. After CN treatment, the expression levels of active caspase-1, PYCARD, and NLRP3 were remarkably decreased in the treatment groups compared with the model group. To sum up, CN is highly protective against H. pylori-induced cell damage and apoptosis; CN can depress NLRP3 inflammasome activation and ROS production via the ROS\/NLRP3\/caspase-1\/IL-1\u03b2 signaling axis to suppress H. pylori-triggered inflammatory response and pyroptosis.<\/jats:p>","DOI":"10.1155\/2022\/5469236","type":"journal-article","created":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T20:20:07Z","timestamp":1657916407000},"page":"1-8","source":"Crossref","is-referenced-by-count":15,"title":["The Anti-Inflammatory Effect of Callicarpa nudiflora Extract on H. 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