{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:55:55Z","timestamp":1767167755404,"version":"build-2238731810"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,6,25]],"date-time":"2022-06-25T00:00:00Z","timestamp":1656115200000},"content-version":"vor","delay-in-days":175,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contrast Media &amp; Molecular Imaging"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    For investigating the correlation with spectral CT imaging parameters and occult lymph nodes metastasis in sufferers with isolated lung adenocarcinoma. The clinic cases data of 352 sufferers with isolated lung adenocarcinoma from January 2019 to January 2022 were assembled. In line with whether the sufferers had occult lymph nodes metastasis, they were taken as a part in the metastasis group (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009172) and the nonmetastasis group. All sufferers were scanned by spectral CT with a dual\u2010phase contrast\u2010enhanced method, and the recording of spectral CT imaging parameters in arteriovenous phase, iodine concentration (IC), water concentration (WC), the slope rate of the spectral HU curve (\n                    <jats:italic>\u03bb<\/jats:italic>\n                    HU), the normalized iodine concentration(NIC), the normalized water concentration(NWC), the normalized effective atomic number (Neff\u2010Z)], and receiver operating characteristic (ROC) were employed to analyze the spectral CT imaging parameters of the arteriovenous phase. Evaluation of occult lymph nodes metastases in sufferers with isolated lung adenocarcinoma. The IC, NIC,\n                    <jats:italic>\u03bb<\/jats:italic>\n                    HU, and Neff\u2010Z in the arteriovenous phase spectral CT imaging parameters of the metastasis group were obviously smaller than that of the nonmetastasis group, and the discrepancies were statistically obvious (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05). The results of ROC curve analysis manifested that the area under the curve (AUC) of\n                    <jats:italic>\u03bb<\/jats:italic>\n                    HU, IC, NIC, and Neff\u2010Z in the CT parameters of the arterial phase were 0. 840 (95%CI\u2009:\u20090. 796\u20130.883), 0.763 (95% CI\u2009:\u20090.708\u20130.818), 0.918 (95% CI\u2009:\u20090.888\u20130.948), 0.778 (95% CI\u2009:\u20090.731\u20130.826). The AUCs of\n                    <jats:italic>\u03bb<\/jats:italic>\n                    HU, IC, NIC, and Neff\u2010Z in the venous phase spectral CT parameters were 0.909 (95% CI\u2009:\u20090.877\u20130.941), 0.837 (95% CI\u2009:\u20090.792\u20130.881), and 0.980 (95% CI\u2009:\u20090.968\u20130.968), respectively. 0.993), 0.792 (95% CI\u2009:\u20090.742\u223c0.842). Spectral CT imaging parameters have a certain value in evaluating occult lymph nodes metastasis in sufferers with isolated lung adenocarcinoma, which is helpful for doctors to judge the lymph nodes metastasis in sufferers with this disease before surgery.\n                  <\/jats:p>","DOI":"10.1155\/2022\/5472446","type":"journal-article","created":{"date-parts":[[2022,6,25]],"date-time":"2022-06-25T23:35:09Z","timestamp":1656200109000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["[Retracted] Correlation with Spectral CT Imaging Parameters and Occult Lymph Nodes Metastases in Sufferers with Isolated Lung Adenocarcinoma"],"prefix":"10.1155","volume":"2022","author":[{"given":"Ye","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1556-2263","authenticated-orcid":false,"given":"Yongkang","family":"Nie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,25]]},"reference":[{"key":"e_1_2_8_1_2","first-page":"55","article-title":"Activation of mitochondrial 2-oxoglutarate dehydrogenase by cocarboxylase in human lung adenocarcinoma cells A549 is p53\/p21-Dependent and impairs cellular redox state, mimicking the cisplatin action","volume":"2","author":"Bunik V. 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