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To observe the effect of total glycosides of Xiebai on chronic unpredictable stimuli in rats. Changes of serotonin (5-HT), dopamine (DA), norepinephrine (NE), serum corticosterone (CORT), adrenocorticotropic hormone (ACTH), organ index, and histopathology in brain tissue, to explore the treatment and characteristics of total white glucosides in depression model, were prepared by different stimuli in 21 days. Methods. Depression models were replicated by 21 days of chronic mild stimulation in rats. Finally, the levels of CORT and ACTH in the serum of rats with depression model and the levels of NE, DA, and 5-HT in brain homogenates were determined. The thymus and spleen wet weight of each group were measured, and the organ index was calculated. The thymus and pituitary were observed under the light microscope. Pathological changes of the hypothalamus, adrenal gland, and spleen and behavioral indexes of rats in each group were determined. Results. The results of the experiment showed that 21 days of chronic unpredictable stimulation significantly improved the behavioral response of the model group, and the levels of corticosterone and adrenocorticotropic hormone in the serum and the indicators in the brain homogenate significantly changed, affecting the relevant tissues. The index changes and the results of the combination can prove that this modeling method can be used for the preparation of depression models. The total white glucoside group can significantly improve the above effects, demonstrating that total glucosides of glucoside have a good therapeutic effect on the rat model of depression. Conclusion. The chronic unpredictability of the total dose of Xiebai glycosides can significantly improve the levels of NE and DA and the levels of serum CORT and ACTH in the brain homogenate of depressive model rats and improve the immune function of the body.<\/jats:p>","DOI":"10.1155\/2022\/5498130","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T23:05:07Z","timestamp":1648595107000},"page":"1-8","source":"Crossref","is-referenced-by-count":5,"title":["Pharmacological Study on Total Glycosides of Xiebai Protecting against Depression Model"],"prefix":"10.1155","volume":"2022","author":[{"given":"Hui","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"},{"name":"College of Postgraduates, Henan University of Chinese Medicine, Zhengzhou 450000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiqiong","family":"Jiang","sequence":"additional","affiliation":[{"name":"College of Postgraduates, Henan University of Chinese Medicine, Zhengzhou 450000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7083-5885","authenticated-orcid":true,"given":"Mingsan","family":"Miao","sequence":"additional","affiliation":[{"name":"College of Postgraduates, Henan University of Chinese Medicine, Zhengzhou 450000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"1","key":"1","first-page":"93","article-title":"Research status of comorbid metabolic syndrome in depression","volume":"27","author":"Li. 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