{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:39:02Z","timestamp":1790699942397,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T00:00:00Z","timestamp":1663113600000},"content-version":"vor","delay-in-days":256,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Ureterorenoscopy (URS) is believed to be a safe and effective procedure for treating ureteral stones or ureteral strictures. Rapidly increasing intrarenal pressure during URS may have a negative impact on the kidney, but its effect on renal function is not well known. The aim of this study was to evaluate whether URS balloon dilation or lithotripsy could cause acute kidney injury (AKI), which was evaluated using urine neutrophil gelatinase\u2010associated lipocalin (NGAL), and renal tubular damage, which was evaluated using urine <jats:italic>\u03b1<\/jats:italic>\u2010glutathione S\u2010transferase (GST) and <jats:italic>\u03c0<\/jats:italic>GST. This prospective study included 207 patients with a mean age of 53.8 years between September 2012 and June 2013. Four groups were included: the ureteral stricture group (group 1), the ureteral stone group (group 2), and two control groups. URS increased urine NGAL (uNGAL) levels on days 1 and 14 in both groups, and only elevated uGST levels were noted on day 14 after URS lithotripsy (URS). On day 14, the difference between low\u2010grade and high\u2010grade hydronephrosis was significant in group 1 (<jats:italic>p<\/jats:italic> &lt; 0.001) compared to that in group 2 (<jats:italic>p<\/jats:italic> = 0.150). Multivariate logistic regression analysis revealed that age, baseline estimated glomerular filtration rate (eGFR), and stone\u2009size &gt; 1.0\u2009cm were associated with the complete recovery of hydronephrosis after URS on day 14. Patients with ureteral stones with preserved renal function had more AKI than those with impaired renal function. However, there was no significant difference in URS\u2010related AKI between the \u22641\u2009cm and &gt;1\u2009cm subgroups. In addition, urine <jats:italic>\u03b1<\/jats:italic>GST and <jats:italic>\u03c0<\/jats:italic>GST levels were both significantly higher in the stone &gt; 1\u2009cm subgroup than in the \u22641\u2009cm subgroup. In conclusion, URS laser lithotripsy and balloon dilatation resulted in AKI and renal tubular damage on day 14, although post\u2010URS double\u2010J (DBJ) stenting was performed in every patient.<\/jats:p>","DOI":"10.1155\/2022\/5505969","type":"journal-article","created":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T23:20:07Z","timestamp":1663197607000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Ureterorenoscopic (URS) Lithotripsy and Balloon Dilation Cause Acute Kidney Injury and Distal Renal Tubule Damage: A Prospective 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