{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:37:59Z","timestamp":1790797079638,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T00:00:00Z","timestamp":1652400000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["14\/2014"],"award-info":[{"award-number":["14\/2014"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["14\/2014"],"award-info":[{"award-number":["14\/2014"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,5,13]]},"abstract":"<jats:p>Purpose. To investigate the anti-inflammatory and antioxidant activities of N-salicyloyltryptamine (NST) in experimental models of carrageenan (Cg)-induced peritonitis in mice, and evaluation of the effects of NST on Cg-induced joint disability in rats. Methods. Female Swiss mice were submitted to Cg-induced peritonitis in mice or Cg-induced joint disability in rats after intraperitoneal injection of NST (100 or 200\u2009mg\/kg). Total leukocyte count, total protein concentration, myeloperoxidase (MPO) and catalase (CAT) activities, and nitrite (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:msubsup>\n                           <a:mrow>\n                              <a:mtext>NO<\/a:mtext>\n                           <\/a:mrow>\n                           <a:mn>2<\/a:mn>\n                           <a:mo>\u2212<\/a:mo>\n                        <\/a:msubsup>\n                     <\/a:math>\n                  <\/jats:inline-formula>) and thiobarbituric acid reactive species (TBARS) levels were determined. Results. NST significantly decrease the migration of leukocytes to peritoneal exudate. Cg induces inflammatory responses mediated by expression of reactive oxygen species (ROS). The results further showed that NST significantly decreased MPO and CAT activities, as well as reduced <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:msubsup>\n                           <c:mrow>\n                              <c:mtext>NO<\/c:mtext>\n                           <\/c:mrow>\n                           <c:mn>2<\/c:mn>\n                           <c:mo>\u2212<\/c:mo>\n                        <\/c:msubsup>\n                     <\/c:math>\n                  <\/jats:inline-formula> and TBARS levels, compared with the vehicle group. Animals treated with NST significantly reduced paw elevation time (PET) on the first hour after induction of joint injury, and this effect was sustained throughout the analysis. Conclusion. NST presented anti-inflammatory and antioxidant effects in experimental models of carrageenan-induced peritonitis and joint disability in mice and rats, respectively, which may be related to the modulation of neutrophils migration as well as the involvement of antioxidant mechanisms.<\/jats:p>","DOI":"10.1155\/2022\/5524107","type":"journal-article","created":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T23:20:29Z","timestamp":1652484029000},"page":"1-8","source":"Crossref","is-referenced-by-count":9,"title":["Anti-Inflammatory and Antioxidant Effects of the Indole-Derived N-Salicyloyltryptamine on Peritonitis and Joint Disability Induced by Carrageenan in Rodents"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5287-5034","authenticated-orcid":true,"given":"B. P.","family":"Sousa-Neto","sequence":"first","affiliation":[{"name":"Medicinal Plants Research Center, Federal University of Piaui, Av. Universit\u00e1ria s\/n, Campus Ministro Petr\u00f4nio Portella, SG-15, Ininga, 64049-550 Teresina, PI, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7927-7747","authenticated-orcid":true,"given":"F. V. M.","family":"Cunha","sequence":"additional","affiliation":[{"name":"Medicinal Plants Research Center, Federal University of Piaui, Av. Universit\u00e1ria s\/n, Campus Ministro Petr\u00f4nio Portella, SG-15, Ininga, 64049-550 Teresina, PI, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0723-389X","authenticated-orcid":true,"given":"Daniel Barbosa","family":"Nunes","sequence":"additional","affiliation":[{"name":"Medicinal Plants Research Center, Federal University of Piaui, Av. 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