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Sixty-eight common targets for the treatment of novel coronavirus pneumonia (NCP) and influenza virus pneumonia (IVP) were also obtained. A \u201ccomponent-target-disease\u201d network was constructed with Cytoscape 3.2.1 software, and 20 key targets, such as cyclooxygenase2 (COX2), interleukin-6 (IL-6), mitogen-activated protein kinase14 (Mapk14), and tumor necrosis factor (TNF), were screened from the network. The David database was used to perform a Kyoto Encyclopedia of Genes and Genomes (KEGG) signal pathway enrichment analysis and gene ontology (GO) biological process enrichment. Results showed that the key targets of LHQW in the treatment of NCP and IVP mainly involved biological processes, such as immune system process intervention, cell proliferation, apoptosis and invasion, toxic metabolism, cytokine activity, and regulation of the synthesis process. KEGG enrichment analysis revealed that 115 signalling pathways were related to the treatment of LHQW. Amongst them, IL-17, T cell receptor, Th17\u2009cell differentiation, TNF, toll-like receptor, MAPK, apoptosis, and seven other signalling pathways were closely related to the occurrence and development of NCP and IVP. Molecular docking showed that each component had different degrees of binding with six targets, namely, 3C-like protease (3CL), angiotensin-converting enzyme 2 (ACE2), COX2, hemagglutinin (HA), IL-6, and neuraminidase (NA). Rutin, isoforsythiaside A, hesperidin and isochlorogenic acid B were the best components for docking with the six core targets. The first five components with the best docking results were isoforsythiaside, hesperidin, isochlorogenic acid B, forsythin E, and quercetin. In conclusion, LHQW has many components, targets, and pathways. The findings of this work can provide an important theoretical basis for determining the mechanism of LHQW in treating NCP and IVP.<\/jats:p>","DOI":"10.1155\/2022\/5536266","type":"journal-article","created":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T11:50:45Z","timestamp":1644321045000},"page":"1-17","source":"Crossref","is-referenced-by-count":17,"title":["Exploration of the Mechanism of Lianhua Qingwen in Treating Influenza Virus Pneumonia and New Coronavirus Pneumonia with the Concept of \u201cDifferent Diseases with the Same Treatment\u201d Based on Network Pharmacology"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0151-6047","authenticated-orcid":true,"given":"Huihui","family":"Su","sequence":"first","affiliation":[{"name":"College of Pharmacy, Sanquan College of Xinxiang Medical University, Xinxiang 453000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7365-8087","authenticated-orcid":true,"given":"Guosong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Baiyun Branch of Nanfang Hospital of Southern Medical University, Guangzhou 510599, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3531-921X","authenticated-orcid":true,"given":"Lulu","family":"Zhan","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Sanquan College of Xinxiang Medical University, Xinxiang 453000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4299-2266","authenticated-orcid":true,"given":"Fei","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Sanquan College of Xinxiang Medical University, Xinxiang 453000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5298-4505","authenticated-orcid":true,"given":"Huiqin","family":"Qian","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Sanquan College of Xinxiang Medical University, Xinxiang 453000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9499-5242","authenticated-orcid":true,"given":"Yanling","family":"Li","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Sanquan College of Xinxiang Medical University, Xinxiang 453000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1408-7472","authenticated-orcid":true,"given":"Ximei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Clinical Pharmacists, The Maternal and Child Health Care Hospital of HuaDu District (Huzhong Hospital), Guangzhou 510800, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"11","key":"1","first-page":"200","article-title":"Clinical application and research progress of Lianhua Qingwen preparation","volume":"31","author":"J. 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