{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T22:42:11Z","timestamp":1778539331972,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T00:00:00Z","timestamp":1645660800000},"content-version":"vor","delay-in-days":54,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Oxidative stress injury (OSI) is an important pathological process in lung ischemia\u2010reperfusion injury (LIRI), and diabetes mellitus (DM) can exacerbate this injury. Dexmedetomidine protects against LIRI by reducing OSI. However, the effect of dexmedetomidine on LIRI under diabetic conditions remains unclear. Therefore, this study is aimed at exploring the effects and mechanisms of dexmedetomidine on OSI induced by LIRI in diabetic rats. Rats were randomly divided into control+sham (CS), DM+sham (DS), control+ischemia\u2010reperfusion (CIR), DM+ischemia\u2010reperfusion (DIR), and DM+ischemia\u2010reperfusion+dexmedetomidine (DIRD) groups (<jats:italic>n<\/jats:italic> = 6). In the CS and DS groups, the nondiabetic and diabetic rats underwent thoracotomy only without LIRI. In the CIR, DIR, and DIRD groups, LIRI was induced through left hilum occlusion for 60\u2009min, followed by reperfusion for 120\u2009min in nondiabetic and diabetic rats, and rats in the DIRD group were administered dexmedetomidine (3, 5, and 10\u2009<jats:italic>\u03bc<\/jats:italic>g\/kg). Compared with those in the CS group, the OSI, lung compliance, apoptosis, and oxygenation indices deteriorated in the DS group (<jats:italic>P<\/jats:italic> &lt; 0.05), and these indices were further aggravated in the CIR and DIR groups (<jats:italic>P<\/jats:italic> &lt; 0.05), being the worst in the DIR group (<jats:italic>P<\/jats:italic> &lt; 0.05). Compared to those of the DIR group, the OSI, lung compliance (15.8 \u00b1 2.4 vs. 11.6 \u00b1 1.7\u2009ml\/kg), apoptosis (22.5 \u00b1 2.6 vs. 51.8 \u00b1 5.7), oxygenation (381 \u00b1 58 vs. 308 \u00b1 78\u2009mmHg), and caspase\u20103 and caspase\u20109 protein expression indices were attenuated, and Nrf2 and sulfiredoxin1 protein expression was increased in the DIRD group (<jats:italic>P<\/jats:italic> &lt; 0.05). And the lung injury, oxygenation, OSI, and Nrf2 and sulfiredoxin1 protein expression changed in a concentration\u2010dependent manner. In conclusion, dexmedetomidine alleviated lung OSI and improved lung function in a diabetic rat LIRI model through the Nrf2\u2010sulfiredoxin1 pathway.<\/jats:p>","DOI":"10.1155\/2022\/5584733","type":"journal-article","created":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T23:50:19Z","timestamp":1645746619000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Dexmedetomidine Alleviates Lung Oxidative Stress Injury Induced by Ischemia\u2010Reperfusion in Diabetic Rats via the Nrf2\u2010Sulfiredoxin1 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