{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:28:29Z","timestamp":1753885709168,"version":"3.41.2"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T00:00:00Z","timestamp":1644364800000},"content-version":"vor","delay-in-days":39,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Support Project of High-level Teachers in Beijing Municipal Universities in the Period of 13th Five Plan","award":["IDHT20170516","KM201810025005"],"award-info":[{"award-number":["IDHT20170516","KM201810025005"]}]},{"name":"Beijing Municipal Science and Technology Project","award":["IDHT20170516","KM201810025005"],"award-info":[{"award-number":["IDHT20170516","KM201810025005"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p><jats:italic>Background and Objective.<\/jats:italic> Gastric cancer (GC) is the fifth most frequently diagnosed cancer and the third leading cause of cancer death worldwide. Recurrence and metastasis are very common in advanced gastric cancer and indicate poor prognosis. We attempted to establish a recurrence\u2010associated gene panel to predict the prognosis for gastric cancer. <jats:italic>Methods.<\/jats:italic> Two datasets were used as training and validation cohorts to establish the predictive model. We used three types of screening criteria: background analysis, pathway analysis, and functional analysis provided by the cBioportal website. Fisher\u2019s exact test and multivariable logistic regression were performed to screen out related genes. Furthermore, we performed receiver operating characteristic (ROC) and Kaplan\u2013Meier curve analyses to evaluate the correlation between the selected genes and overall survival. <jats:italic>Result.<\/jats:italic> We screened five genes (KNL1, NRXN1, C6, CCDC169\u2010SOHLH2, and TTN) that were highly related to recurrence of GC. The area under the receiver operating characteristic (ROC) curve was 0.813, which was much higher than that of the baseline model (AUC = 0.699). This result suggested that the mutation of five selected genes had a significant effect on the prediction of recurrence compared with other factors (age, stages, history, etc.). Furthermore, the Kaplan\u2010Meier estimator also revealed that the mutation of five genes positively correlated with patient survival. <jats:italic>Conclusions.<\/jats:italic> The patients who have mutations in these five genes may experience longer survival than those who do not have mutations. This five\u2010gene panel will likely be a practical tool for prognostic evaluation and will provide another possible way for clinicians to determine therapy.<\/jats:p>","DOI":"10.1155\/2022\/5593619","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T17:35:05Z","timestamp":1644428105000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Identification of a Five\u2010Gene Panel to Assess Prognosis for Gastric 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