{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T13:50:33Z","timestamp":1792849833309,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T00:00:00Z","timestamp":1652659200000},"content-version":"vor","delay-in-days":135,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","award":["RSP-2021\/26"],"award-info":[{"award-number":["RSP-2021\/26"]}],"id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004242","name":"Princess Nourah Bint Abdulrahman University","doi-asserted-by":"publisher","award":["PNURSP2022R62"],"award-info":[{"award-number":["PNURSP2022R62"]}],"id":[{"id":"10.13039\/501100004242","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p><jats:italic>Schinus molle<\/jats:italic> is a medicinal plant used as an anti\u2010inflammatory and for rheumatic pain in the traditional medicine of Peru. On the other hand, <jats:italic>Aedes aegypti<\/jats:italic> is the main vector of several tropical diseases and the transmitter of yellow fever, chikungunya, malaria, dengue, and Zika virus. In this study, the aim was to investigate the antioxidant activity in vitro and the insecticidal activity in silico, in the presence of the mosquito juvenile hormone\u2010binding protein (mJHBP) from <jats:italic>Aedes aegypti<\/jats:italic>, of the essential oil from <jats:italic>S. molle<\/jats:italic> leaves. The volatile phytochemicals were analyzed by gas chromatography\u2010mass spectrometry (GC\u2010MS), and the profile antioxidants were examined by DPPH, ABTS, and FRAP assays. The evaluation in silico was carried out on mJHBP (PDB: 5V13) with an insecticidal approach. The results revealed that EO presented as the main volatile components to alpha\u2010phellandrene (32.68%), D\u2010limonene (12.59%), and beta\u2010phellandrene (12.24%). The antioxidant activity showed values for DPPH = 11.42 \u00b1 0.08\u2009<jats:italic>\u03bc<\/jats:italic>mol\u2009ET\/g, ABTS = 134.88 \u00b1 4.37\u2009<jats:italic>\u03bc<\/jats:italic>mol\u2009ET\/g, and FRAP = 65.16 \u00b1 1.46\u2009<jats:italic>\u03bc<\/jats:italic>mol\u2009ET\/g. Regarding the insecticidal approach in silico, alpha\u2010muurolene and gamma\u2010cadinene had the best biding energy on mJHBP (<jats:italic>\u0394<\/jats:italic><jats:italic>G<\/jats:italic> = \u22129.7\u2009kcal\/mol), followed by beta\u2010cadinene (<jats:italic>\u0394<\/jats:italic><jats:italic>G<\/jats:italic> = \u22129.5\u2009kcal\/mol). Additionally, the volatile components did not reveal antioxidant activity, and its potential insecticidal effect would be acting on mJHBP from <jats:italic>A. aegypti.<\/jats:italic><\/jats:p>","DOI":"10.1155\/2022\/5601531","type":"journal-article","created":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T23:35:10Z","timestamp":1652744110000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["GC\u2010MS Profile, Antioxidant Activity, and In Silico Study of the Essential Oil from <i>Schinus molle<\/i> L. Leaves in the Presence of Mosquito Juvenile Hormone\u2010Binding Protein (mJHBP) from <i>Aedes aegypti<\/i>"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7264-0961","authenticated-orcid":false,"given":"Oscar","family":"Herrera-Calderon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8717-4307","authenticated-orcid":false,"given":"Haydee","family":"Chavez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4089-5905","authenticated-orcid":false,"given":"Edwin Carlos","family":"Enciso-Roca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1744-4874","authenticated-orcid":false,"given":"Pablo 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