{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T11:41:07Z","timestamp":1792237267861,"version":"4.4.0"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T00:00:00Z","timestamp":1659916800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science and Technology Research and Development Program of Qinhuangdao","award":["201805A141"],"award-info":[{"award-number":["201805A141"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2022,8,8]]},"abstract":"<jats:p>The collagen from jellyfish has many beneficial effects, including antioxidant, anti-inflammatory and immune-modulatory activities. However, whether jellyfish collagen hydrolysate (JCH) has any effects on high-fat diet-induced obesity remains unknown. Consequently, we in the present study orally administrated JCH in high-fat diet-fed mice to explore its effects on body weight gain, inflammatory and oxidative status, and cecum microbe composition. The results showed that oral administration of JCH prevented the body weight gain in high-fat diet-treated mice. Meanwhile, glucose, triglycerides, and total cholesterol level in serum were maintained by JCH administration. Furthermore, JCH administration alleviated oxidative stress by increasing the GSH content and decreasing the level reactive oxygen species in the liver and improved inflammatory response by decreasing the expression of TNF-\u03b1, IL-1\u03b2, and IL-8 gene in the liver and ileum. Importantly, JCH administration helps recover the alteration of microbiota composition induced by high-fat diet, and the genus Romboutsia may critically involve in the beneficial effects of JCH administration. In conclusion, our results indicated that JCH could be potentially used for the prevention and treatment of diet-induced obesity.<\/jats:p>","DOI":"10.1155\/2022\/5628702","type":"journal-article","created":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T03:20:13Z","timestamp":1660015213000},"page":"1-8","source":"Crossref","is-referenced-by-count":12,"title":["Jellyfish Collagen Hydrolysate Alleviates Inflammation and Oxidative Stress and Improves Gut Microbe Composition in High-Fat Diet-Fed Mice"],"prefix":"10.1155","volume":"2022","author":[{"given":"Zhe","family":"Lv","sequence":"first","affiliation":[{"name":"Department of Emergency, The First Hospital of Qinhuangdao, Qinhuangdao, 066000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9888-3408","authenticated-orcid":true,"given":"Chongyang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Emergency, The First Hospital of Qinhuangdao, Qinhuangdao, 066000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Song","sequence":"additional","affiliation":[{"name":"Ministry of Natural Resources (MNR) Key Laboratory of Marine Eco-Environmental Science and Technology, First Institute of Oceanography, Ministry of Natural Resources, Qingdao, 266061, China"},{"name":"Laboratory of Marine Ecology and Environmental Science, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266235, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingsong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Emergency, The First Hospital of Qinhuangdao, Qinhuangdao, 066000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaohui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Emergency, The First Hospital of Qinhuangdao, Qinhuangdao, 066000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2012.675326"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2010.12.013"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.3390\/md9060967"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2013.11.003"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.80154"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B0920081"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2017.11.009"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1017\/S0954422410000168"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.aninu.2020.08.011"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201700262"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2021.08.025"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2006.01.015"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2005.02.005"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.3645"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2004.12.025"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.60076"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.3390\/nu5010223"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0000000000000209"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i40.8905"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7343"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2020.12.032"}],"container-title":["Mediators of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2022\/5628702.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2022\/5628702.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2022\/5628702.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T03:20:20Z","timestamp":1660015220000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/mi\/2022\/5628702\/"}},"subtitle":[],"editor":[{"given":"Hongmei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,8,8]]},"references-count":21,"alternative-id":["5628702","5628702"],"URL":"https:\/\/doi.org\/10.1155\/2022\/5628702","relation":{},"ISSN":["1466-1861","0962-9351"],"issn-type":[{"value":"1466-1861","type":"electronic"},{"value":"0962-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8,8]]}}}