{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T03:43:01Z","timestamp":1770522181129,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T00:00:00Z","timestamp":1659139200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,7,30]]},"abstract":"<jats:p>Objective. The aim of this study is to investigate the effect of paclitaxel combined with doxorubicin hydrochloride liposome injection (DHLI) in the treatment of osteosarcoma and the MRI changes before and after treatment. Methods. A total of 108 osteosarcoma patients treated in our hospital (January 2020\u2013April 2022) were selected to carry out a single-center retrospective study. Among them, 54 patients receiving the combination chemotherapy (MDT) with high-dose methotrexate, ifosfamide, cisplatin, and ADM were selected as the control group (COG), while 54 patients receiving MDT with high-dose methotrexate, ifosfamide, cisplatin, paclitaxel, and DHLI were chosen as the study group (STG). The COG and STG had the same dose intensity and chemotherapy cycles, and clinical and MRI evaluations were performed after treatment. Results. The evaluation of postoperative clinical efficacy showed that the disease control rate (DCR) of the STG was markedly higher than that of the COG (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). The incidence of cardiac toxicity was remarkably lower in the STG than that in the COG (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.05<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>), with no between-group differences in the incidence of fever, abnormal liver function, myelosuppression, stomatitis, and alopecia (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>&gt;<\/e:mo>\n                        <e:mn>0.05<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>). Obvious differences were found in the semiquantitative parameters of MRI in the STG before and after chemotherapy (<jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                        <g:mo>&lt;<\/g:mo>\n                        <g:mn>0.05<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>) and were also found in the SImax, TTP, SEE, PPE, WOR, and R values in the COG before and after chemotherapy (<jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>P<\/i:mi>\n                        <i:mo>&lt;<\/i:mo>\n                        <i:mn>0.05<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>). After chemotherapy, statistical differences were observed in the semiquantitative parameters of MRI between the two groups, with lower parameters such as Slope, SImax, SEE, and R values and higher parameters such as TTP, PPE, and WOR values in the STG than those in the COG (<jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mi>P<\/k:mi>\n                        <k:mo>&lt;<\/k:mo>\n                        <k:mn>0.05<\/k:mn>\n                     <\/k:math>\n                  <\/jats:inline-formula>). Conclusion. Paclitaxel combined with DHLI has definite efficacy in osteosarcoma chemotherapy, which is conducive to narrowing the lesion, controlling the disease, and reducing the occurrence of cardiac-related risk events. In addition, the semiquantitative parameters of dynamic contrast-enhanced MRI (DCE-MRI) have a high predictive value for the efficacy of chemotherapy, which can reflect the degree of tumor necrosis and contribute to a timely and objective assessment of the efficacy of osteosarcoma chemotherapy.<\/jats:p>","DOI":"10.1155\/2022\/5651793","type":"journal-article","created":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T19:50:07Z","timestamp":1659210607000},"page":"1-7","source":"Crossref","is-referenced-by-count":5,"title":["Effect of Paclitaxel Combined with Doxorubicin Hydrochloride Liposome Injection in the Treatment of Osteosarcoma and MRI Changes before and after Treatment"],"prefix":"10.1155","volume":"2022","author":[{"given":"Ning","family":"Tian","sequence":"first","affiliation":[{"name":"Department of Medical Imaging, Shandong Provincial Third Hospital, Jinan 250031, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongmei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Shandong Provincial Third Hospital, Jinan 250031, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaobao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Shandong Provincial Third Hospital, Jinan 250031, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minghua","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Ultrasonography, Shandong Provincial Qianfoshan Hospital, The First Affiliated Hospital of Shandong First Medical University, Jinan 250014, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3842-0698","authenticated-orcid":true,"given":"Bo","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Shandong Provincial Third Hospital, Jinan 250031, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bulcan.2021.01.006"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6528\/ab055f"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-017-3377-3"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-018-3643-3"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2017.1382692"},{"issue":"20","key":"6","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1001\/jama.2013.281053","article-title":"World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects","volume":"310","author":"World Medical Association","year":"2013","journal-title":"JAMA"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-017-3278-9"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.2174\/1871520617666171121124610"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-021-07748-6"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1002\/jor.24143"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-018-3079-1"},{"key":"12","doi-asserted-by":"crossref","first-page":"28135","DOI":"10.1016\/j.suronc.2018.11.018","article-title":"Inter-rater variability in the interpretation of pre and post contrast mri for pre-surgical evaluation of osteosarcoma in long bones in pediatric patients and young adults","volume":"28","author":"T. 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