{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:03:34Z","timestamp":1792695814766,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"vor","delay-in-days":202,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971593"],"award-info":[{"award-number":["81971593"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771824"],"award-info":[{"award-number":["81771824"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contrast Media &amp; Molecular Imaging"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. The objective of this study was to determine the value of dynamic contrast\u2010enhanced magnetic resonance imaging (DCE\u2010MRI) in assessing postoperative changes in intracranial gliomas. <jats:italic>Method<\/jats:italic>. A total of fifty\u2010one patients who had new enhanced lesions after surgical resection followed by standard radiotherapy and chemotherapy were collected retrospectively from October 2014 to June 2021. The patients were divided into a pseudoprogression group (15 cases) and a recurrence group (36 cases) according to the pathological results of the second operation or a follow\u2010up of more than six months. The follow\u2010up data of all patients were complete, and DCE\u2010MRI was performed. The images were processed to obtain the quantitative parameters <jats:italic>K<\/jats:italic><jats:sup>trans<\/jats:sup>, Ve, and Kep and the semiquantitative parameter iAUC, which were analysed with relevant statistical software. <jats:italic>Results<\/jats:italic>. First, the difference in <jats:italic>K<\/jats:italic><jats:sup>trans<\/jats:sup> and iAUC values between the two groups was statistically significant (<jats:italic>P<\/jats:italic>\u2009<jats:italic>&lt;<\/jats:italic>\u2009<jats:italic>0.05<\/jats:italic>), and the difference in Ve and Kep values was not statistically significant (<jats:italic>P<\/jats:italic>\u2009<jats:italic>&gt;<\/jats:italic>\u2009<jats:italic>0.05<\/jats:italic>). Second, by comparing the area under the curve, threshold, sensitivity and specificity of <jats:italic>K<\/jats:italic><jats:sup>trans<\/jats:sup>, and iAUC, it was found that the iAUC threshold value was slightly higher than that of <jats:italic>K<\/jats:italic><jats:sup>trans<\/jats:sup>, and the specificity of <jats:italic>K<\/jats:italic><jats:sup>trans<\/jats:sup> was equal to that of iAUC, while the area under the curve and sensitivity of <jats:italic>K<\/jats:italic><jats:sup>trans<\/jats:sup> were higher than those of iAUC. Third, <jats:italic>K<\/jats:italic><jats:sup>trans<\/jats:sup> and iAUC had high accuracy in diagnosing recurrence and pseudoprogression, and <jats:italic>K<\/jats:italic><jats:sup>trans<\/jats:sup> had higher accuracy than iAUC. <jats:italic>Conclusion<\/jats:italic>. In this study, DCE\u2010MRI has a certain diagnostic value in the early differentiation of recurrence and pseudoprogression, offering a new method for the diagnosis and assessment of gliomas after surgery.<\/jats:p>","DOI":"10.1155\/2022\/5680522","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T18:50:10Z","timestamp":1658515810000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The Value of Dynamic Contrast\u2010Enhanced Magnetic Resonance Imaging (DCE\u2010MRI) in the Differentiation of Pseudoprogression and Recurrence of Intracranial Gliomas"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4412-764X","authenticated-orcid":false,"given":"Hui","family":"Jing","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7393-2680","authenticated-orcid":false,"given":"Xuhong","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6410-5296","authenticated-orcid":false,"given":"Junjie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5855-1011","authenticated-orcid":false,"given":"Danlei","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3541-9074","authenticated-orcid":false,"given":"Ning","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0565-0411","authenticated-orcid":false,"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,22]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0708126"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(18)30990-5"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rcl.2019.07.003"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.2217\/fon.15.258"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-019-06122-x"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10143-017-0921-1"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.26171"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/0284185119896519"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2017.6895"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.26621"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.3171\/2016.3.jns14243"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurad.2018.04.008"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6207"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-016-1741-7"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/jon.12239"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.2478\/raon-2020-0037"},{"key":"e_1_2_12_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-015-1893-z"},{"key":"e_1_2_12_18_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.14132632"},{"key":"e_1_2_12_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2011.01.018"},{"key":"e_1_2_12_20_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.a4908"},{"key":"e_1_2_12_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nov095"},{"key":"e_1_2_12_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-6-121"},{"key":"e_1_2_12_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinimag.2015.04.003"},{"key":"e_1_2_12_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1754-9485.2012.02472.x"},{"key":"e_1_2_12_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-016-4692-9"},{"key":"e_1_2_12_26_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4218"},{"key":"e_1_2_12_27_2","doi-asserted-by":"publisher","DOI":"10.1177\/0284185112474916"},{"key":"e_1_2_12_28_2","doi-asserted-by":"publisher","DOI":"10.1177\/0284185116681038"},{"key":"e_1_2_12_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-017-4789-9"},{"key":"e_1_2_12_30_2","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20200699"},{"key":"e_1_2_12_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2018.01.009"},{"key":"e_1_2_12_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2020.109445"}],"container-title":["Contrast Media &amp; 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