{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:38:21Z","timestamp":1791434301132,"version":"4.3.3"},"reference-count":9,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,3,26]],"date-time":"2022-03-26T00:00:00Z","timestamp":1648252800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Interventional Cardiology"],"published-print":{"date-parts":[[2022,3,26]]},"abstract":"<jats:p>Objectives. Evaluation of the safety and efficacy of the Penumbra device as an adjunct to percutaneous coronary intervention (PCI) in patients with myocardial infarction (MI) and a large thrombus burden that requires thrombectomy. Background. For patients with acute MI, PCI is the primary reperfusion method. Large thrombus burden has always been a limitation of successful reperfusion. However, the use of current aspiration devices has been associated with an increased incidence of stroke. Methods. We performed a retrospective chart review at the University Hospitals Medical Center in Cleveland. Our study included data from patients who underwent PCI for ST segment elevation myocardial infarction (STEMI) and non-ST segment elevation myocardial infarction (NSTEMI) assisted by the Penumbra Cat RX device (a wide-lumen thrombus aspiration catheter) between May 2019 and February 2021. The primary outcome was the final thrombolysis in myocardial infarction (TIMI) flow. The secondary endpoints were a composite of adverse cardiac events at 6\u2009months. About 50% of the patients did undergo transfemoral PCI as per preference of individual operators. The Penumbra thrombectomy device can be used both by radial and femoral approach and does not need any different guide catheter use. Results. TIMI flow 3 was achieved in 111 patients (90.2%). The secondary endpoint occurred in 11 patients (8.9%, 3 MI, 8 heart failure hospitalizations). There were no stroke events or device-related complications. The door-to-balloon time was not affected by usage of the Penumbra device. Failure in the restoration of TIMI 3 flow was associated with the use of balloon angioplasty prior to the application of the Penumbra device, leading to distal embolization. Conclusions. The Penumbra Cat RX provides safe and effective thrombus removal with better clinical outcomes, even in high-risk patients with acute coronary syndrome.<\/jats:p>","DOI":"10.1155\/2022\/5692964","type":"journal-article","created":{"date-parts":[[2022,3,26]],"date-time":"2022-03-26T20:05:18Z","timestamp":1648325118000},"page":"1-6","source":"Crossref","is-referenced-by-count":12,"title":["Routine Use of the \u201cPenumbra\u201d Thrombectomy Device in Myocardial Infarction: A Real-World Experience\u2014ROPUST Study"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7721-1119","authenticated-orcid":true,"given":"Nour","family":"Tashtish","sequence":"first","affiliation":[{"name":"Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek","family":"Chami","sequence":"additional","affiliation":[{"name":"Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Medicine, University Hospitals Cleveland Medical Center, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Besher","family":"Chami","sequence":"additional","affiliation":[{"name":"Department of Medicine, Aleppo University Hospital, Aleppo, Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadeer","family":"Al-Kindi","sequence":"additional","affiliation":[{"name":"Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haytham","family":"Mously","sequence":"additional","affiliation":[{"name":"Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Janus","sequence":"additional","affiliation":[{"name":"Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek","family":"Hammad","sequence":"additional","affiliation":[{"name":"Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi H.","family":"Shishehbor","sequence":"additional","affiliation":[{"name":"Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4722-7205","authenticated-orcid":true,"given":"Anjan","family":"Gupta","sequence":"additional","affiliation":[{"name":"Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.108.831453"},{"key":"2","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1093\/eurheartj\/ehv296","article-title":"Stroke in the TOTAL trial: a randomized trial of routine thrombectomy vs. percutaneous coronary intervention alone in ST elevation myocardial infarction","volume":"36","author":"S. S. J","year":"2015","journal-title":"European Heart Journal"},{"key":"3","first-page":"1135","article-title":"ACC\/AHA\/SCAI focused update on primary percutaneous coronary intervention for patients with ST-elevation myocardial infarctionAn update of the 2011 ACCF\/AHA\/SCAI guideline for percutaneous coronary intervention and the 2013 ACCF\/AHA guideline for the","volume":"133","author":"G. N Levine","year":"2015","journal-title":"Circulation"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.116.025371"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(19)32011-x"},{"key":"6","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1161\/CIR.0b013e3182742c84","article-title":"ACCF\/AHA guideline for the management of ST-elevation myocardial infarction: executive summary: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on practice guidelines","volume":"127","author":"J. L Anderson","year":"2013","journal-title":"Circulation"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1177\/2048872615617044"},{"key":"8"},{"key":"9","first-page":"S27","article-title":"CRT-101.03 sustained mechanical aspiration thrombectomy before PCI in high-thrombus patients, comparing STEMI to NSTEMI: a subset analysis of the CHEETAH study","volume":"15","author":"D. C. Metzger","year":"2022","journal-title":"JACC: Cardiovascular Interventions"}],"container-title":["Journal of Interventional Cardiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jitc\/2022\/5692964.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jitc\/2022\/5692964.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jitc\/2022\/5692964.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,26]],"date-time":"2022-03-26T20:05:25Z","timestamp":1648325125000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/jitc\/2022\/5692964\/"}},"subtitle":[],"editor":[{"given":"Stefano","family":"Rigattieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,3,26]]},"references-count":9,"alternative-id":["5692964","5692964"],"URL":"https:\/\/doi.org\/10.1155\/2022\/5692964","relation":{},"ISSN":["1540-8183","0896-4327"],"issn-type":[{"value":"1540-8183","type":"electronic"},{"value":"0896-4327","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3,26]]}}}