{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:21:45Z","timestamp":1767165705136,"version":"build-2238731810"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T00:00:00Z","timestamp":1641513600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Foundation for the Outstanding Youth Training of 2021 in Tianjin Fourth Central Hospital","award":["tjdszxyy20210007"],"award-info":[{"award-number":["tjdszxyy20210007"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2022,1,7]]},"abstract":"<jats:p>\n                    Purpose. This study aimed to determine whether and how stress-induced thyroid hormone changes occur during the COVID-19 pandemic in the northern area of Tianjin. Methods. This study comprised two groups of study subjects in Tianjin: before (2019) and during (2020) the COVID-19 outbreak. Subjects were included if they had FT3, FT4, and TSH concentrations and thyroid TPOAb or TgAb information available. People who were pregnant, were lactating, or had mental illness were excluded. We used propensity score matching to form a cohort in which patients had similar baseline characteristics, and their anxiety level was measured by the Hamilton Anxiety Rating Scale (HAMA). Results. Among the 1395 eligible people, 224 in Group A and 224 in Group B had similar propensity scores and were included in the analyses. The detection rate of abnormal thyroid function was decreased in pandemic Group B (69.2% vs. 93.3%, \u03c72\u2009=\u200942.725,\n                    <jats:inline-formula>\n                      <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.01<\/a:mn>\n                      <\/a:math>\n                    <\/jats:inline-formula>\n                    ), especially for hypothyroidism (14.29% vs. 35.71%, \u03c72\u2009=\u200927.429,\n                    <jats:inline-formula>\n                      <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.01<\/c:mn>\n                      <\/c:math>\n                    <\/jats:inline-formula>\n                    ) and isolated thyroid-related antibodies (25.89% vs. 38.39%, \u03c72\u2009=\u20098.023,\n                    <jats:inline-formula>\n                      <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>p<\/e:mi>\n                        <e:mo>&lt;<\/e:mo>\n                        <e:mn>0.01<\/e:mn>\n                      <\/e:math>\n                    <\/jats:inline-formula>\n                    ). The level of FT4 (z\u2009=\u2009\u22122.821,\n                    <jats:inline-formula>\n                      <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>p<\/g:mi>\n                        <g:mo>&lt;<\/g:mo>\n                        <g:mn>0.01<\/g:mn>\n                      <\/g:math>\n                    <\/jats:inline-formula>\n                    ) and HAMA score (7.63\u2009\u00b1\u20092.07 vs. 5.40\u2009\u00b1\u20091.65, t\u2009=\u200916.873,\n                    <jats:inline-formula>\n                      <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>p<\/i:mi>\n                        <i:mo>&lt;<\/i:mo>\n                        <i:mn>0.01<\/i:mn>\n                      <\/i:math>\n                    <\/jats:inline-formula>\n                    ) went up in Group B; however, TSH (z\u2009=\u2009\u22125.238,\n                    <jats:inline-formula>\n                      <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mi>p<\/k:mi>\n                        <k:mo>&lt;<\/k:mo>\n                        <k:mn>0.01<\/k:mn>\n                      <\/k:math>\n                    <\/jats:inline-formula>\n                    ), FT3 (z\u2009=\u2009\u22123.089,\n                    <jats:inline-formula>\n                      <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <m:mi>p<\/m:mi>\n                        <m:mo>=<\/m:mo>\n                        <m:mn>0.002<\/m:mn>\n                      <\/m:math>\n                    <\/jats:inline-formula>\n                    ), TgAb (z\u2009=\u2009\u221211.814,\n                    <jats:inline-formula>\n                      <o:math xmlns:o=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\">\n                        <o:mi>p<\/o:mi>\n                        <o:mo>&lt;<\/o:mo>\n                        <o:mn>0.01<\/o:mn>\n                      <\/o:math>\n                    <\/jats:inline-formula>\n                    ), and TPOAb (z\u2009=\u2009\u22129.299,\n                    <jats:inline-formula>\n                      <q:math xmlns:q=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\">\n                        <q:mi>p<\/q:mi>\n                        <q:mo>&lt;<\/q:mo>\n                        <q:mn>0.01<\/q:mn>\n                      <\/q:math>\n                    <\/jats:inline-formula>\n                    ) were lower, and HAMA was positive with FT3 (r\u2009=\u20090.208,\n                    <jats:inline-formula>\n                      <s:math xmlns:s=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\">\n                        <s:mi>p<\/s:mi>\n                        <s:mo>&lt;<\/s:mo>\n                        <s:mn>0.01<\/s:mn>\n                      <\/s:math>\n                    <\/jats:inline-formula>\n                    ) and FT4 (r\u2009=\u20090.247,\n                    <jats:inline-formula>\n                      <u:math xmlns:u=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\">\n                        <u:mi>p<\/u:mi>\n                        <u:mo>&lt;<\/u:mo>\n                        <u:mn>0.01<\/u:mn>\n                      <\/u:math>\n                    <\/jats:inline-formula>\n                    ). Conclusion. People in the northern area of Tianjin during the COVID-19 outbreak were at an increased risk of higher FT4, lower FT3, and lower TSH. The HAMA scores increased in emergency situations and were positively correlated with the levels of FT3 and FT4.\n                  <\/jats:p>","DOI":"10.1155\/2022\/5720875","type":"journal-article","created":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T19:20:11Z","timestamp":1641583211000},"page":"1-7","source":"Crossref","is-referenced-by-count":5,"title":["Thyroid Hormone Changes in the Northern Area of Tianjin during the COVID-19 Pandemic"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7006-7911","authenticated-orcid":true,"given":"Dong","family":"Weiwei","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Tianjin Fourth Central Hospital, The Fourth Central Clinical School, Tianjin Medical University, Tianjin 300140, China"},{"name":"Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin Medical University, Tianjin 300052, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wu","family":"Bei","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin Medical University, Tianjin 300052, China"},{"name":"Department of Nuclear Medicine, Tianjin Hospital, Tianjin 300211, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wang","family":"Hong","sequence":"additional","affiliation":[{"name":"Rehabilitation Medical Department, Tianjin Union Medical Center, Tianjin 300121, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wu","family":"Cailan","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Tianjin Fourth Central Hospital, The Fourth Central Clinical School, Tianjin Medical University, Tianjin 300140, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shao","family":"Hailin","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Medicine, Tianjin Fourth Central Hospital, The Fourth Central Clinical School, Tianjin Medical University, Tianjin 300140, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Donghong","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Medicine, Tianjin Fourth Central Hospital, The Fourth Central Clinical School, Tianjin Medical University, Tianjin 300140, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wang","family":"Xiaolai","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Medicine, Tianjin Fourth Central Hospital, The Fourth Central Clinical School, Tianjin Medical University, Tianjin 300140, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Zhaohu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Medicine, Tianjin Fourth Central Hospital, The Fourth Central Clinical School, Tianjin Medical University, Tianjin 300140, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Shijun","sequence":"additional","affiliation":[{"name":"Department of Hematology, Tianjin Fourth Central Hospital, The Fourth Central Clinical School, Tianjin Medical University, Tianjin 300140, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9705-9791","authenticated-orcid":true,"given":"Tan","family":"Jian","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Tianjin Fourth Central Hospital, The Fourth Central Clinical School, Tianjin Medical University, Tianjin 300140, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Qiang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin Medical University, Tianjin 300052, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"3","key":"1","first-page":"129","article-title":"Expert consensus on the safety prevention and control procedure in nuclear medicine diagnosis and treatment during the outbreak of COVID-19 (1st edition)","volume":"40","author":"Chinese Society of Nuclear Medicine Editorial Board of Chinese Journal of Nuclear Medicine and Molecular Imaging","year":"2020","journal-title":"Chinese Journal of Nuclear Medicine and Molecular Imaging"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1002\/oby.22155"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1017\/s0033291718003495"},{"issue":"1","key":"4","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s42000-020-00230-w","article-title":"Subacute thyroiditis in a patient infected with SARS-COV-2: an endocrine complication linked to the COVID-19 pandemic","volume":"20","author":"R. 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